Table of Contents Author Guidelines Submit a Manuscript
Mediators of Inflammation
Volume 2012, Article ID 512974, 6 pages
http://dx.doi.org/10.1155/2012/512974
Research Article

Inhalative IL-10 Attenuates Pulmonary Inflammation following Hemorrhagic Shock without Major Alterations of the Systemic Inflammatory Response

1Department of Orthopaedic Trauma Surgery, Faculty of Medicine, RWTH Aachen University, Pauwelsstraβe 30, 52074 Aachen, Germany
2Institute of Pharmacology and Toxicology, Faculty of Medicine, RWTH Aachen University, Pauwelsstraβe 30, 52074 Aachen, Germany

Received 29 June 2011; Accepted 23 August 2011

Academic Editor: Frank Hildebrand

Copyright © 2012 Philipp Kobbe et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. R. M. H. Roumen, T. Hendriks, J. Van der Ven-Jongekrijg et al., “Cytokine patterns in patients after major vascular surgery, hemorrhagic shock, and severe blunt trauma. Relation with subsequent adult respiratory distress syndrome and multiple organ failure,” Annals of Surgery, vol. 218, no. 6, pp. 769–776, 1993. View at Google Scholar · View at Scopus
  2. C. C. Finnerty, D. N. Herndon, R. Przkora et al., “Cytokine expression profile over time in severely burned pediatric patients,” Shock, vol. 26, no. 1, pp. 13–19, 2006. View at Publisher · View at Google Scholar · View at Scopus
  3. P. Kobbe, J. Schmidt, B. Stoffels, R. S. Chanthaphavong, A. J. Bauer, and H. C. Pape, “IL-10 administration attenuates pulmonary neutrophil infiltration and alters pulmonary iNOS activation following hemorrhagic shock,” Inflammation Research, vol. 58, no. 3, pp. 170–174, 2009. View at Publisher · View at Google Scholar · View at Scopus
  4. P. Kobbe, B. Stoffels, J. Schmidt et al., “IL-10 deficiency augments acute lung but not liver injury in hemorrhagic shock,” Cytokine, vol. 45, no. 1, pp. 26–31, 2009. View at Publisher · View at Google Scholar · View at Scopus
  5. A. Ayala, D. L. Lehman, C. D. Herdon et al., “Mechanism of enhanced susceptibility to sepsis following hemorrhage. Interleukin-10 suppression of T-cell response is mediated by eicosanoid-induced interleukin-4 release,” Archives of Surgery, vol. 129, no. 11, pp. 1172–1178, 1994. View at Google Scholar · View at Scopus
  6. G. Y. Song, C. S. Chung, I. H. Chaudry, and A. Ayala, “What is the role of interleukin 10 in polymicrobial sepsis: anti-inflammatory agent or immunosuppressant?” Surgery, vol. 126, no. 2, pp. 378–383, 1999. View at Publisher · View at Google Scholar · View at Scopus
  7. K. Yamakami, S. Akao, T. Tadakuma, Y. Nitta, J. I. Miyazaki, and N. Yoshizawa, “Administration of plasmids expressing interleukin-4 and interleukin-10 causes BALB/c mice to induce a T helper 2-type response despite the expected T helper 1-type response with a low-dose infection of Leishmania major,” Immunology, vol. 105, no. 4, pp. 515–523, 2002. View at Publisher · View at Google Scholar · View at Scopus
  8. H. Kobayashi, M. Kobayashi, D. N. Herndon, R. B. Pollard, and F. Suzuki, “Susceptibility of thermally injured mice to cytomegalovirus infection,” Burns, vol. 27, no. 7, pp. 675–680, 2001. View at Publisher · View at Google Scholar · View at Scopus
  9. K. W. Moore, M. R. de Waal, R. L. Coffman, and A. O'Garra, “Interleukin-10 and the interleukin-10 receptor,” Annual Review of Immunology, vol. 19, pp. 683–765, 2001. View at Publisher · View at Google Scholar · View at Scopus
  10. C. Woiciechowsky, K. Asadullah, D. Nestler et al., “Sympathetic activation triggers systemic interleukin-10 release in immunodepression induced by brain injury,” Nature Medicine, vol. 4, no. 7, pp. 808–813, 1998. View at Publisher · View at Google Scholar · View at Scopus
  11. M. Bivas-Benita, R. Zwier, H. E. Junginger, and G. Borchard, “Non-invasive pulmonary aerosol delivery in mice by the endotracheal route,” European Journal of Pharmaceutics and Biopharmaceutics, vol. 61, no. 3, pp. 214–218, 2005. View at Publisher · View at Google Scholar · View at Scopus
  12. K. Asadullah, W. Sterry, and H. D. Volk, “Interleukin-10 therapy—review of a new approach,” Pharmacological Reviews, vol. 55, no. 2, pp. 241–269, 2003. View at Publisher · View at Google Scholar · View at Scopus
  13. M. B. Welborn III, L. L. Moldawer, J. M. Seeger, R. M. Minter, and T. S. Huber, “Role of endogenous interleukin-10 in local and distant organ injury after visceral ischemia-reperfusion,” Shock, vol. 20, no. 1, pp. 35–40, 2003. View at Google Scholar · View at Scopus
  14. C. P. Schneider, M. G. Schwacha, and I. H. Chaudry, “The role of interleukin-10 in the regulation of the systemic inflammatory response following trauma-hemorrhage,” Biochimica et Biophysica Acta, vol. 1689, no. 1, pp. 22–32, 2004. View at Publisher · View at Google Scholar · View at Scopus
  15. T. J. Ferrer, J. W. Webb, B. H. Wallace et al., “Interleukin-10 reduces morbidity and mortality in murine multiple organ dysfunction syndrome (MODS),” Journal of Surgical Research, vol. 77, no. 2, pp. 157–164, 1998. View at Publisher · View at Google Scholar · View at Scopus
  16. D. F. Fiorentino, A. Zlotnik, T. R. Mosmann, M. Howard, and A. O'Garra, “IL-10 inhibits cytokine production by activated macrophages,” Journal of Immunology, vol. 147, no. 11, pp. 3815–3822, 1991. View at Google Scholar · View at Scopus
  17. M. G. Schwacha, C. P. Schneider, K. I. Bland, and I. H. Chaudry, “Resistance of macrophages to the suppressive effect of interleukin-10 following thermal injury,” The American Journal of Physiology, vol. 281, no. 4, pp. C1180–C1187, 2001. View at Google Scholar · View at Scopus
  18. M. Keel, U. Ungethüm, U. Steckholzer et al., “Interleukin-10 counterregulates proinflammatory cytokine-induced inhibition of neutrophil apoptosis during severe sepsis,” Blood, vol. 90, no. 9, pp. 3356–3363, 1997. View at Google Scholar · View at Scopus
  19. C. Stamme, D. S. Bundschuh, T. Hartung et al., “Temporal sequence of pulmonary and systemic inflammatory responses to graded polymicrobial peritonitis in mice,” Infection and Immunity, vol. 67, no. 11, pp. 5642–5650, 1999. View at Google Scholar · View at Scopus
  20. H. Wrigge, U. Uhlig, J. Zinserling et al., “The effects of different ventilatory settings on pulmonary and systemic inflammatory responses during major surgery,” Anesthesia and Analgesia, vol. 98, no. 3, pp. 775–781, 2004. View at Google Scholar · View at Scopus
  21. S. M. Opal and V. A. DePalo, “Anti-inflammatory cytokines,” Chest, vol. 117, no. 4, pp. 1162–1172, 2000. View at Google Scholar · View at Scopus
  22. M. N. Gong, B. T. Thompson, P. L. Williams et al., “Interleukin-10 polymorphism in position-1082 and acute respiratory distress syndrome,” European Respiratory Journal, vol. 27, no. 4, pp. 674–681, 2006. View at Publisher · View at Google Scholar · View at Scopus
  23. R. G. Khadaroo, J. Fan, K. A. Powers, B. Fann, A. Kapus, and O. D. Rotstein, “Impaired induction of IL-10 expression in the lung following hemorrhagic shock,” Shock, vol. 22, no. 4, pp. 333–339, 2004. View at Publisher · View at Google Scholar · View at Scopus
  24. M. Frink, Y. C. Hsieh, C. H. Hsieh et al., “Keratinocyte-derived chemokine plays a critical role in the induction of systemic inflammation and tissue damage after trauma-hemorrhage,” Shock, vol. 28, no. 5, pp. 576–581, 2007. View at Publisher · View at Google Scholar · View at Scopus
  25. S. Karakozis, M. Hinds, J. W. Cook, D. Kim, H. Provido, and J. R. Kirkpatrick, “The effects of interleukin-10 in hemorrhagic shock,” Journal of Surgical Research, vol. 90, no. 2, pp. 109–112, 2000. View at Publisher · View at Google Scholar · View at Scopus
  26. M. Frink, A. Lu, B. M. Thobe et al., “Monocyte chemoattractant protein-1 influences trauma-hemorrhage-induced distal organ damage via regulation of keratinocyte-derived chemokine production,” The American Journal of Physiology, vol. 292, no. 3, pp. R1110–R1116, 2007. View at Publisher · View at Google Scholar · View at Scopus
  27. A. K. Sharma, L. G. Fernandez, A. S. Awad, I. L. Kron, and V. E. Laubach, “Proinflammatory response of alveolar epithelial cells is enhanced by alveolar macrophage-produced TNF-α during pulmonary ischemia-reperfusion injury,” The American Journal of Physiology, vol. 293, no. 1, pp. L105–L113, 2007. View at Publisher · View at Google Scholar · View at Scopus
  28. M. Zhao, L. G. Fernandez, A. Doctor et al., “Alveolar macrophage activation is a key initiation signal for acute lung ischemia-reperfusion injury,” The American Journal of Physiology, vol. 291, no. 5, pp. L1018–L1026, 2006. View at Publisher · View at Google Scholar · View at Scopus
  29. S. R. Baldwin, C. M. Grum, L. A. Boxer, and L. J. Devall, “Oxidant activity in expired breath of patients with adult respiratory distress syndrome,” The Lancet, vol. 1, no. 8471, pp. 11–14, 1986. View at Google Scholar · View at Scopus
  30. A. I. Rivkind, J. H. Siegel, M. Littleton et al., “Neutrophil oxidative burst activation and the pattern of respiratory physiologic abnormalities in the fulminant post-traumatic adult respiratory distress syndrome,” Circulatory Shock, vol. 33, no. 1, pp. 48–62, 1991. View at Google Scholar · View at Scopus
  31. P. J. Hess, J. M. Seeger, T. S. Huber et al., “Exogenously administered interleukin-10 decreases pulmonary neutrophil infiltration in a tumor necrosis factor-dependent murine model of acute visceral ischemia,” Journal of Vascular Surgery, vol. 26, no. 1, pp. 113–118, 1997. View at Publisher · View at Google Scholar · View at Scopus
  32. G. Inoue, “Effect of interleukin-10 (IL-10) on experimental LPS-induced acute lung injury,” Journal of Infection and Chemotherapy, vol. 6, no. 1, pp. 51–60, 2000. View at Google Scholar · View at Scopus
  33. G. Malleo, E. Mazzon, T. Genovese et al., “Absence of endogenous interleukin-10 enhanced organ dysfunction and mortality associated to zymosan-induced multiple organ dysfunction syndrome,” Cytokine, vol. 41, no. 2, pp. 136–143, 2008. View at Publisher · View at Google Scholar · View at Scopus
  34. S. C. Donnelly, R. M. Strieter, P. T. Reid et al., “The association between mortality rates and decreased concentrations of interleukin-10 and interleukin-1 receptor antagonist in the lung fluids of patients with the adult respiratory distress syndrome,” Annals of Internal Medicine, vol. 125, no. 3, pp. 191–196, 1996. View at Google Scholar · View at Scopus