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Mediators of Inflammation
Volume 2013, Article ID 436329, 8 pages
http://dx.doi.org/10.1155/2013/436329
Clinical Study

Body Mass Index: A Risk Factor for Retinopathy in Type 2 Diabetic Patients

1Department of Ophthalmology, Clinical Hospital Dubrava, Avenija Gojka Šuška 6, 10000 Zagreb, Croatia
2Department of Ophthalmology, University Clinic Vuk Vrhovac, Clinical Hospital Merkur, Zajčeva 19, 10000 Zagreb, Croatia
3Department of Ophthalmology, General Hospital Dubrovnik, Dr. Roka Mišetića 2, 20000 Dubrovnik, Croatia
4Department of Endocrinology and Metabolic Diseases, University Clinic Vuk Vrhovac, Clinical Hospital Merkur, Zajčeva 19, 10000 Zagreb, Croatia
5University of Applied Sciences Velika Gorica, Zagrebačka Cesta 5, 10410 Velika Gorica, Croatia

Received 14 September 2013; Accepted 27 October 2013

Academic Editor: Katarzyna Zorena

Copyright © 2013 Snježana Kaštelan et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. N. Friedman and E. L. Fanning, “Overweight and obesity: an overview of prevalence, clinical impact, and economic impact,” Disease Management, vol. 7, no. 1, pp. S1–S6, 2004. View at Google Scholar · View at Scopus
  2. D. W. Haslam and W. P. T. James, “Obesity,” The Lancet, vol. 366, no. 9492, pp. 1197–1209, 2005. View at Publisher · View at Google Scholar · View at Scopus
  3. P. T. James, “Obesity: the worldwide epidemic,” Clinics in Dermatology, vol. 22, no. 4, pp. 276–280, 2004. View at Publisher · View at Google Scholar · View at Scopus
  4. X. Formiguera and A. Cantón, “Obesity: epidemiology and clinical aspects,” Best Practice and Research, vol. 18, no. 6, pp. 1125–1146, 2004. View at Publisher · View at Google Scholar · View at Scopus
  5. S. Van Dieren, J. W. J. Beulens, Y. T. Van Der Schouw, D. E. Grobbee, and B. Neal, “The global burden of diabetes and its complications: an emerging pandemic,” European Journal of Cardiovascular Prevention and Rehabilitation, vol. 17, no. 1, supplement, pp. S3–S8, 2010. View at Publisher · View at Google Scholar · View at Scopus
  6. J. E. Shaw, R. A. Sicree, and P. Z. Zimmet, “Global estimates of the prevalence of diabetes for 2010 and 2030,” Diabetes Research and Clinical Practice, vol. 87, no. 1, pp. 4–14, 2010. View at Publisher · View at Google Scholar · View at Scopus
  7. G. Roglic, N. Unwin, P. H. Bennett et al., “The burden of mortality attributable to diabetes: realistic estimates for the year 2000,” Diabetes Care, vol. 28, no. 9, pp. 2130–2135, 2005. View at Publisher · View at Google Scholar · View at Scopus
  8. S. E. Moss, R. Klein, and B. E. K. Klein, “The 14-year incidence of visual loss in a diabetic population,” Ophthalmology, vol. 105, no. 6, pp. 998–1003, 1998. View at Publisher · View at Google Scholar · View at Scopus
  9. L. M. Aiello, “Perspectives on diabetic retinopathy,” American Journal of Ophthalmology, vol. 136, no. 1, pp. 122–135, 2003. View at Publisher · View at Google Scholar · View at Scopus
  10. M. I. Harris, R. Klein, T. A. Welborn, and M. W. Knuiman, “Onset of NIDDM occurs at least 4-7 yr before clinical diagnosis,” Diabetes Care, vol. 15, no. 7, pp. 815–819, 1992. View at Google Scholar · View at Scopus
  11. R. Turner, C. Cull, and R. Holman, “United Kingdom prospective diabetes study 17: a 9-year update of a randomized, controlled trial on the effect of improved metabolic control on complications in non-insulin-dependent diabetes mellitus,” Annals of Internal Medicine, vol. 124, no. 1, pp. 136–145, 1996. View at Google Scholar · View at Scopus
  12. Diabetes Control and Complication Trial / Epidemiology of Diabetes Interventions and Complications Research Group, “Retinopathy and nephropathy in patients with type 1 diabetes four years after a trial of intensive therapy,” New England Journal of Medicine, vol. 342, no. 6, pp. 381–389, 2000. View at Google Scholar
  13. I. M. Stratton, E. M. Kohner, S. J. Aldington et al., “UKPDS 50: risk factors for incidence and progression of retinopathy in Type II diabetes over 6 years from diagnosis,” Diabetologia, vol. 44, no. 2, pp. 156–163, 2001. View at Publisher · View at Google Scholar · View at Scopus
  14. S. Kaštelan, M. Tomić, J. Pavan, and S. Orešković, “Maternal immune system adaptation to pregnancy—a potential influence on the course of diabetic retinopathy,” Reproductive Biology and Endocrinology, vol. 8, p. 124, 2010. View at Google Scholar
  15. J. W. J. Beulens, A. Patel, J. R. Vingerling et al., “Effects of blood pressure lowering and intensive glucose control on the incidence and progression of retinopathy in patients with type 2 diabetes mellitus: a randomised controlled trial,” Diabetologia, vol. 52, no. 10, pp. 2027–2036, 2009. View at Publisher · View at Google Scholar · View at Scopus
  16. F. Ismail-Beigi, T. Craven, M. A. Banerji et al., “Effect of intensive treatment of hyperglycaemia on microvascular outcomes in type 2 diabetes: an analysis of the ACCORD randomised trial,” The Lancet, vol. 376, no. 9739, pp. 419–430, 2010. View at Publisher · View at Google Scholar · View at Scopus
  17. N. Cheung and T. Y. Wong, “Obesity and eye diseases,” Survey of Ophthalmology, vol. 52, no. 2, pp. 180–195, 2007. View at Publisher · View at Google Scholar · View at Scopus
  18. N. Chaturvedi, J. H. Fuller, R. J. Jarrett et al., “Mortality risk by body weight and weight change in people with NIDDM: the WHO multinational study of vascular disease in diabetes,” Diabetes Care, vol. 18, no. 6, pp. 766–774, 1995. View at Google Scholar · View at Scopus
  19. M. Henricsson, L. Nyström, G. Blohmé et al., “The incidence of retinopathy 10 years after diagnosis in young adult people with diabetes: results from the nationwide population-based Diabetes Incidence Study in Sweden (DISS),” Diabetes Care, vol. 26, no. 2, pp. 349–354, 2003. View at Publisher · View at Google Scholar · View at Scopus
  20. R. Turner, “Effect of intensive blood-glucose control with metformin on complications in overweight patients with type 2 diabetes (UKPDS 34),” The Lancet, vol. 352, no. 9131, pp. 854–865, 1998. View at Publisher · View at Google Scholar · View at Scopus
  21. H. A. Van Leiden, J. M. Dekker, A. C. Moll et al., “Risk factors for incident retinopathy in a diabetic and nondiabetic population: the Hoorn study,” Archives of Ophthalmology, vol. 121, no. 2, pp. 245–251, 2003. View at Google Scholar · View at Scopus
  22. M. Dirani, J. Xie, E. Fenwick et al., “Are obesity and anthropometry risk factors for diabetic retinopathy? The diabetes management project,” Investigative Ophthalmology & Visual Science, vol. 52, no. 7, pp. 4416–4421, 2011. View at Google Scholar · View at Scopus
  23. D. Katušić, M. Tomić, T. Jukić et al., “Obesity—a risk factor for diabetic retinopathy in type 2 diabetes?” Collegium Antropologicum, vol. 29, supplement, pp. 47–50, 2005. View at Google Scholar
  24. L. Zhang, G. Krzentowski, A. Albert, and P. J. Lefebvre, “Risk of developing retinopathy in diabetes control and complications trial type 1 diabetic patients with good or poor metabolic control,” Diabetes Care, vol. 24, no. 7, pp. 1275–1279, 2001. View at Google Scholar · View at Scopus
  25. X. Li and Z. Wang, “Prevalence and incidence of retinopathy in elderly diabetic patients receiving early diagnosis and treatment,” Experimental and Therapeutic Medicine, vol. 5, no. 5, pp. 1393–1396, 2013. View at Google Scholar
  26. C. E. M. De Block, I. H. De Leeuw, and L. F. Van Gaal, “Impact of overweight on chronic microvascular complications in type 1 diabetic patients,” Diabetes Care, vol. 28, no. 7, pp. 1649–1655, 2005. View at Publisher · View at Google Scholar · View at Scopus
  27. R. Klein, B. E. K. Klein, and S. E. Moss, “Is obesity related to microvascular and macrovascular complications in diabetes? The Wisconsin epidemiologic study of diabetic retinopathy,” Archives of Internal Medicine, vol. 157, no. 6, pp. 650–656, 1997. View at Google Scholar · View at Scopus
  28. R. Klein, B. E. K. Klein, and S. E. Moss, “The Wisconsin epidemiologic study of diabetic retinopathy—III. Prevalence and risk of diabetic retinopathy when age at diagnosis is 30 or more years,” Archives of Ophthalmology, vol. 102, no. 4, pp. 527–532, 1984. View at Google Scholar · View at Scopus
  29. L. S. Lim, E. Shyong Tai, P. Mitchell et al., “C-reactive protein, body mass index, and diabetic retinopathy,” Investigative Ophthalmology and Visual Science, vol. 51, no. 9, pp. 4458–4463, 2010. View at Publisher · View at Google Scholar · View at Scopus
  30. R. Raman, P. K. Rani, P. Gnanamoorthy, R. R. Sudhir, G. Kumaramanikavel, and T. Sharma, “Association of obesity with diabetic retinopathy: Sankara nethralaya diabetic retinopathy epidemiology and molecular genetics study (SN-DREAMS Report no. 8),” Acta Diabetologica, vol. 47, no. 3, pp. 209–215, 2010. View at Publisher · View at Google Scholar · View at Scopus
  31. G. K. Dowse, A. R. G. Humphrey, V. R. Collins et al., “Prevalence and risk factors for diabetic retinopathy in the multiethnic population of Mauritius,” American Journal of Epidemiology, vol. 147, no. 5, pp. 448–457, 1998. View at Google Scholar · View at Scopus
  32. American Diabetes Association, “Diagnosis and classification of diabetes mellitus,” Diabetes Care, vol. 30, supplement 1, pp. S42–S47, 2007. View at Google Scholar
  33. M. Vučić Lovrenčić and E. Topić, “Hemoglobin A1c: standardizacija ‘zlatnog standarda’,” Biochemia Medica, vol. 16, no. 1, pp. 25–36, 2006. View at Google Scholar
  34. P. N. M. Demacker, G. J. M. Boerma, and H. Baadenhuijsen, “Evaluation of accuracy of 20 different test kits for the enzymic determination of cholesterol,” Clinical Chemistry, vol. 29, no. 11, pp. 1916–1922, 1983. View at Google Scholar · View at Scopus
  35. M. W. McGowan, J. D. Artiss, D. R. Strandbergh, and B. Zak, “A peroxidase-coupled method for the colorimetric determination of serum triglycerides,” Clinical Chemistry, vol. 29, no. 3, pp. 538–542, 1983. View at Google Scholar · View at Scopus
  36. S. K. Kumanyika, E. Obarzanek, N. Stettler et al., “Population-based prevention of obesity: the need for comprehensive promotion of healthful eating, physical activity, and energy balance: a scientific statement from American Heart Association Council on Epidemiology and Prevention, Interdisciplinary Committee for prevention (formerly the expert panel on population and prevention science),” Circulation, vol. 118, no. 4, pp. 428–464, 2008. View at Publisher · View at Google Scholar · View at Scopus
  37. S. J. Aldington, E. M. Kohner, S. Meuer, R. Klein, and A. K. Sjolie, “Methodology for retinal photography and assessment of diabetic retinography: the EURODIAB IDDM complications study,” Diabetologia, vol. 38, no. 4, pp. 437–444, 1995. View at Publisher · View at Google Scholar · View at Scopus
  38. R. R. Sokal and F. J. Rohlf, Biometry: The Principles and Practice of Statistics in Biological Research, W. H. Freeman and Co., New York, NY, USA, 3rd edition, 1995.
  39. StatSoft, Inc, “Electronic Statistics Textbook,” StatSoft, Tulsa, Okla, USA, 2011, http://www.statsoft.com/textbook.
  40. J. W. Y. Yau, S. L. Rogers, R. Kawasaki et al., “Global prevalence and major risk factors of diabetic retinopathy,” Diabetes Care, vol. 35, no. 3, pp. 556–564, 2012. View at Publisher · View at Google Scholar · View at Scopus
  41. R. J. Tapp, J. E. Shaw, C. A. Harper et al., “The prevalence of and factors associated with diabetic retinopathy in the Australian population,” Diabetes Care, vol. 26, no. 6, pp. 1731–1737, 2003. View at Publisher · View at Google Scholar · View at Scopus
  42. R. Williams, M. Airey, H. Baxter, J. Forrester, T. Kennedy-Martin, and A. Girach, “Epidemiology of diabetic retinopathy and macular oedema: a systematic review,” Eye, vol. 18, no. 10, pp. 963–983, 2004. View at Publisher · View at Google Scholar · View at Scopus
  43. S. E. Moss, R. Klein, and B. E. K. Klein, “Ten-year incidence of visual loss in a diabetic population,” Ophthalmology, vol. 101, no. 6, pp. 1061–1070, 1994. View at Google Scholar · View at Scopus
  44. D. R. Matthews, I. M. Stratton, S. J. Aldington, R. R. Holman, and E. M. Kohner, “Risks of progression of retinopathy and vision loss related to tight blood pressure control in type 2 diabetes mellitus: UKPDS 69,” Archives of Ophthalmology, vol. 122, no. 11, pp. 1631–1640, 2004. View at Publisher · View at Google Scholar · View at Scopus
  45. R. W. Schrier, R. O. Estacio, P. S. Mehler, and W. R. Hiatt, “Appropriate blood pressure control in hypertensive and normotensive type 2 diabetes mellitus: a summary of the ABCD trial,” Nature Clinical Practice Nephrology, vol. 3, no. 8, pp. 428–438, 2007. View at Publisher · View at Google Scholar · View at Scopus
  46. “The Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation and Treatment of High Blood Pressure: The JNC VII report,” Journal of the American Medical Association, vol. 289, no. 19, pp. 2560–2572, 2003.
  47. A. Zanchetti, “Guidelines for the management of arterial hypertension,” Journal of Hypertension, vol. 21, no. 6, pp. 1011–1053, 2003. View at Publisher · View at Google Scholar · View at Scopus
  48. The diabetes control and complications trial research group, “The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. The Diabetes Control and Complications Trial Research Group,” New England Journal of Medicine, vol. 329, no. 14, pp. 977–986, 1993. View at Google Scholar
  49. P. Reichard, B.-Y. Nilsson, and U. Rosenqvist, “The effect of long-term intensified insulin treatment on the development of microvascular complications of diabetes mellitus,” New England Journal of Medicine, vol. 329, no. 5, pp. 304–309, 1993. View at Publisher · View at Google Scholar · View at Scopus
  50. A. Gray, “Cost effectiveness analysis of improved blood pressure control in hypertensive patients with type 2 diabetes: UKPDS 40,” British Medical Journal, vol. 317, no. 7160, pp. 720–726, 1998. View at Google Scholar · View at Scopus
  51. E. E. Calle, M. J. Thun, J. M. Petrelli, C. Rodriguez, and C. W. Heath Jr., “Body-mass index and mortality in a prospective cohort of U.S. adults,” New England Journal of Medicine, vol. 341, no. 15, pp. 1097–1105, 1999. View at Publisher · View at Google Scholar · View at Scopus
  52. E. Haupt, A. Benecke, A. Haupt, R. Herrmann, H. Vogel, and C. Walter, “The KID study VI: diabetic complications and associated diseases in younger type 2 diabetics still performing a profession, prevalence and correlation with duration of diabetic state, BMI and C-peptide,” Experimental and Clinical Endocrinology and Diabetes, vol. 107, no. 7, pp. 435–441, 1999. View at Google Scholar · View at Scopus
  53. H. Dorchy, C. Claes, and C. Verougstraete, “Risk factors of developing proliferative retinopathy in type 1 diabetic patients: role of BMI,” Diabetes Care, vol. 25, no. 4, pp. 798–799, 2002. View at Google Scholar · View at Scopus
  54. J. V. Silha, M. Krsek, P. Sucharda, and L. J. Murphy, “Angiogenic factors are elevated in overweight and obese individuals,” International Journal of Obesity, vol. 29, no. 11, pp. 1308–1314, 2005. View at Publisher · View at Google Scholar · View at Scopus
  55. L. P. Aiello, R. L. Avery, P. G. Arrigg et al., “Vascular endothelial growth factor in ocular fluid of patients with diabetic retinopathy and other retinal disorders,” New England Journal of Medicine, vol. 331, no. 22, pp. 1480–1487, 1994. View at Publisher · View at Google Scholar · View at Scopus
  56. S. Miyazawa-Hoshimoto, K. Takahashi, H. Bujo, N. Hashimoto, and Y. Saito, “Elevated serum vascular endothelial growth factor is associated with visceral fat accumulation in human obese subjects,” Diabetologia, vol. 46, no. 11, pp. 1483–1488, 2003. View at Publisher · View at Google Scholar · View at Scopus
  57. M. M. J. van Greevenbroek, C. G. Schalkwijk, and C. D. A. Stehouwer, “Obesity-associated low-grade inflammation in type 2 diabetes mellitus: causes and consequences,” The Netherlands Journal of Medicine, vol. 71, no. 4, pp. 174–187, 2013. View at Google Scholar
  58. H. Kwon and J. E. Pessin, “Adipokines mediate inflammation and insulin resistance,” Frontiers in Endocrinology, vol. 4, no. 71, pp. 1–13, 2013. View at Google Scholar
  59. E. Fuentes, F. Fuentes, G. Vilahur, L. Badimon, and I. Palomo, “Mechanisms of chronic state of inflammation as mediators that link obese adipose tissue and metabolic syndrome,” Mediators of Inflammation, vol. 2013, Article ID 136584, 11 pages, 2013. View at Publisher · View at Google Scholar
  60. L. F. Van Gaal, I. L. Mertens, and C. E. De Block, “Mechanisms linking obesity with cardiovascular disease,” Nature, vol. 444, no. 7121, pp. 875–880, 2006. View at Publisher · View at Google Scholar · View at Scopus
  61. G. Uckaya, M. Ozata, Z. Bayraktar, V. Erten, N. Bingol, and I. C. Ozdemir, “Is leptin associated with diabetic retinopathy?” Diabetes Care, vol. 23, no. 3, pp. 371–376, 2000. View at Google Scholar · View at Scopus
  62. M. Matsuda, F. Kawasaki, K. Yamada et al., “Impact of adiposity and plasma adipocytokines on diabetic angiopathies in Japanese Type 2 diabetic subjects,” Diabetic Medicine, vol. 21, no. 8, pp. 881–888, 2004. View at Publisher · View at Google Scholar · View at Scopus
  63. M. R. Sierra-Honigmann, A. K. Nath, C. Murakami et al., “Biological action of leptin as an angiogenic factor,” Science, vol. 281, no. 5383, pp. 1683–1686, 1998. View at Publisher · View at Google Scholar · View at Scopus
  64. J. M. Fernández-Real, P. Botas-Cervero, A. López-Bermano et al., “Adiponectin is independently associated with glycosylated haemoglobin,” European Journal of Endocrinology, vol. 150, no. 2, pp. 201–205, 2004. View at Publisher · View at Google Scholar · View at Scopus
  65. F. L. Ferris, E. Y. Chew, and B. J. Hoogwerf, “Serum lipids and diabetic retinopathy,” Diabetes Care, vol. 19, no. 11, pp. 1291–1293, 1996. View at Google Scholar · View at Scopus
  66. R. Klein, A. R. Sharrett, B. E. K. Klein et al., “The association of atherosclerosis, vascular risk factors, and retinopathy in adults with diabetes: the Atherosclerosis Risk in Communities Study,” Ophthalmology, vol. 109, no. 7, pp. 1225–1234, 2002. View at Publisher · View at Google Scholar · View at Scopus
  67. E. M. Kohner, S. J. Aldington, I. M. Stratton et al., “United kingdom prospective diabetes study, 30: diabetic retinopathy at diagnosis of non-insulin-dependent diabetes mellitus and associated risk factors,” Archives of Ophthalmology, vol. 116, no. 3, pp. 297–303, 1998. View at Google Scholar · View at Scopus
  68. T. Y. Wong, B. B. Duncan, S. H. Golden et al., “Associations between the metabolic syndrome and retinal microvascular signs: the atherosclerosis risk in communities study,” Investigative Ophthalmology & Visual Science, vol. 45, no. 9, pp. 2949–2954, 2004. View at Publisher · View at Google Scholar · View at Scopus
  69. M. Tomić, S. Ljubić, and S. Kaštelan, “The role of inflammation and endothelial dysfunction in the pathogenesis of diabetic retinopathy,” Collegium Antropologicum, vol. 37, supplement 1, pp. 51–57, 2013. View at Google Scholar
  70. K. Khavandi, H. Amer, B. Ibrahim, and J. Brownrigg, “Strategies for preventing type 2 diabetes: an update for clinicians,” Therapeutic Advances in Chronic Disease, vol. 4, no. 5, pp. 242–261, 2013. View at Google Scholar
  71. N. F. Sheard, “Moderate changes in weight and physical activity can prevent or delay the development of type 2 diabetes mellitus in susceptible individuals,” Nutrition Reviews, vol. 61, no. 2, pp. 76–79, 2003. View at Publisher · View at Google Scholar · View at Scopus
  72. L. Sjöström, A.-K. Lindroos, M. Peltonen et al., “Lifestyle, diabetes, and cardiovascular risk factors 10 years after bariatric surgery,” New England Journal of Medicine, vol. 351, no. 26, pp. 2683–2693, 2004. View at Publisher · View at Google Scholar · View at Scopus
  73. M. T. Zanella, O. Kohlmann Jr., and A. B. Ribeiro, “Treatment of obesity hypertension and diabetes syndrome,” Hypertension, vol. 38, no. 3, pp. 705–708, 2001. View at Google Scholar · View at Scopus