Mediators of Inflammation

Research Article

A Plasma Proteomic Approach in Rett Syndrome: Classical versus Preserved Speech Variant

Table 1

Identification of plasma proteins in RTT patients and healthy controls by MS.


ID	AC^a	Protein name	Short name	pI/Mr (kDa) predicted	pI/Mr (kDa) experimental	Peptide matches	Sequence coverage (%)	MOWSE score	Biological process involved; molecular function; references

1	P02760	Alpha-1-microglobulin	AMBP	5.07/30.9	5/31.1	9/15	25	77	Host-virus interaction; trypsin and plasmin inhibitor; [16]
2	P10909	Clusterin	CLUS	4.9/36.9	4.8/36.4	12/18	25	146	Chaperone; prevents stress-induced aggregation of blood plasma proteins; [17]
3	P00738	Haptoglobin	HPT	5.4/16.8	5.2/17	6/14	19	75	Immunity; captures hemoglobin, antimicrobial, and antioxidant; [18]
4	P00738	Haptoglobin	HPT	6.07/16.8	5.9/17	6/13	19	73	Immunity; captures hemoglobin, antimicrobial, and antioxidant; [18]
5	P02675	Fibrinogen beta chain	FIBB	6.4/55.2	6.6/55.2	37/88	60	231	Blood coagulation and hemostasis; [19]
6	P02768	Serum albumin	ALBU	5.6/67.7	5.8/68	5/7	8	56	Regulation of the osmotic blood pressure; binds ions, hormones, and fatty acids; [20]
7	P01591	Immunoglobulin J chain	IGJ	4.5/23.4	4.5/24	5/18	32	61	Immunity; links two monomer units of either IgM or IgA; [21]
8	P68871	Hemoglobin subunit beta	HBB	6.8/10.5	6.4/12.5	6/9	53	110	Oxygen transport; [22]
9	P01009	Alpha-1-antitrypsin	A1AT	4.8/50.3	4.8/50.2	10/14	32	141	Serine proteases inhibitor; [23]
10	P68871	Hemoglobin subunit beta	HBB	7.05/10.5	6.8/12.5	15/31	95	220	Oxygen transport; [22]
11	P01859	Ig gamma-2 chain C region	IGHG2	6.1/24.4	6/24.6	7/40	17	44	Immunity; antigen binding; [24]
12	P02787	Serum transferrin	TRFE	6.3/80.7	6.3/79.3	36/71	45	311	Iron binding transport proteins which can bind two Fe³⁺ ions; [25]
13	P01024	Complement C3	CO3	6.6/70.6	6.8/69.7	16/21	14	144	Immunity; central role in the activation of the complement system; [26]
14	P02766	Transthyretin	TTHY	5.5/35.3	5.4/34.4	9/27	77	136	Thyroid hormone-binding protein; [27]

Spot ID refers to that shown in 2-DE maps (Figure 1). ^aAccession numbers of Swiss-Prot or GenBanK databases.