A Plasma Proteomic Approach in Rett Syndrome: Classical versus Preserved Speech Variant

Table 2

Quantitative and qualitative protein variations values.

ID

AC^a

Short name

Classical versus PSV

RTT versus healthy controls

Family 1 (F1) versus Family 2 (F2)

No. 1 Classical versus no. 3 Classical

No. 2 PSV versus no. 4 PSV

No. 2, no. 4

No. 1, no. 3

Controls

F1, F2

F2

F1

No. 3

No. 1

No. 4

No. 2

1

P02760

AMBP

0.63±0.69

1.29±0.35

1.92±0.36

0.96±0.63

0.80±0.88

1.12±0.18

1.59±0.12

0.99±0.12^∗

n.d.

1.26±0.11

2

P10909

CLUS

0.93±1.02

1.21±0.34

0.51±0.23

1.07±0.74^∗∗

0.75±0.83

1.39±0.52

1.50±0.17

0.92±0.05^∗

n.d.

1.87±0.08

3

P00738

HPT

2.14±0.31

3.56±0.19^∗∗

3.56±1.04

2.85±0.78

2.98±0.65

2.72±0.94

3.56±0.16

3.57±0.25

2.40±0.09

1.88±0.18

4

P00738

HPT

2.53±0.80

4.88±0.62^∗∗

5.74±1.49

3.70±1.40^∗∗

3.08±1.41

4.33±1.18

4.35±0.34

5.40±0.08

1.81±0.03

3.26±0.11^∗∗

5

P02675

FIBB

2.02±0.26

3.65±0.63^∗∗

7.35±3.10

2.83±0.97^∗∗

3.01±1.26

2.66±0.62

4.11±0.56

3.18±0.20

1.90±0.16

2.13±0.33

6

P02768

ALBU

0.94±1.02

1.08±1.19

3.49±1.34

1.01±1.06

n.d.

2.02±0.17

n.d.

2.17±0.09

n.d.

1.87±0.04

7

P01591

IGJ

0.22±0.24

n.d.

0.55±0.16

0.11±0.19

n.d.

0.22±0.24

n.d.

n.d.

n.d.

0.43±0.02

8

P68871

HBB

1.34±1.47

2.25±2.46

4.81±2.37

1.80±1.99

1.34±1.47

2.25±2.46

n.d.

4.50±0.04

2.68±0.07

n.d.

9

P01009

A1AT

n.d.

0.60±0.26

2.57±1.24

0.30±0.54

n.d.

0.60±0.26

n.d.

1.20±0.03

n.d.

n.d.

10

P68871

HBB

6.91±2.61

6.59±4.53

10.38±4.30

6.75±3.53^∗

3.85±1.50

9.65±2.25^∗∗

2.93±1.07

10.26±3.15

4.78±1.37

9.03±1.25

11

P01859

IGHG2

1.97±1.56

1.61±0.57

4.16±1.57

1.79±1.14^∗∗

1.34±0.86

2.25±1.27

2.12±0.15

1.11±0.18^∗∗

0.56±0.09

3.39±0.35

12

P02787

TRFE

3.21±0.44

3.11±0.50

10.51±3.90

3.16±0.45^∗∗

3.30±0.61

3.03±0.18

3.26±0.72

2.96±0.22

3.33±0.65

3.09±0.15

13

P01024

CO3

0.99±1.08

2.04±0.31

4.64±1.32

1.51±0.94^∗∗

1.12±1.24

1.91±0.12

2.23±0.34

1.85±0.15

n.d.

1.97±0.06

14

P02766

TTHY

1.34±1.47

5.86±2.91^∗∗

2.61±0.83

3.60±3.20

5.59±3.20

1.61±1.78^∗∗

8.49±0.56

3.23±0.30^∗∗

2.69±0.04

n.d.

Spot ID refers to that shown in 2-DE maps (Figure 1). ^aAccession numbers of Swiss-Prot or GenBanK databases. Proteins values are expressed as relative %V (mean ± SD). For proteins significantly decreased or increased: *P < 0.05, **P < 0.01. n.d.: not detected.