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Mediators of Inflammation
Volume 2013 (2013), Article ID 761789, 6 pages
http://dx.doi.org/10.1155/2013/761789
Review Article

Oxidized LDL and LOX-1 in Experimental Sepsis

1Department of Anesthesia, Pain Management and Perioperative Medicine, Dalhousie University Halifax, Nova Scotia, Canada B3H 2Y9
2Department of Pharmacology, Dalhousie University Halifax, Nova Scotia, Canada B3H 2Y9
3Department of Microbiology and Immunology, Dalhousie University Halifax, Nova Scotia, Canada B3H 2Y9
4Department of Anesthesiology and Operative Intensive Care Medicine, Charité, Universitätsmedizin, Berlin, Germany

Received 23 May 2013; Accepted 13 July 2013

Academic Editor: Asım Orem

Copyright © 2013 Nadia Al-Banna and Christian Lehmann. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. M. Landsberger, J. Zhou, S. Wilk et al., “Inhibition of lectin-like oxidized low-density lipoprotein receptor-1 reduces leukocyte adhesion within the intestinal microcirculation in experimental endotoxemia in rats,” Critical Care, vol. 14, no. 6, article R223, 2010. View at Publisher · View at Google Scholar · View at Scopus
  2. H. Moriwaki, N. Kume, T. Sawamura et al., “Ligand specificity of LOX-1, a novel endothelial receptor for oxidized low density lipoprotein,” Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 18, no. 10, pp. 1541–1547, 1998. View at Google Scholar · View at Scopus
  3. T. Sawamura, N. Kume, T. Aoyama et al., “An endothelial receptor for oxidized low-density lipoprotein,” Nature, vol. 386, no. 6620, pp. 73–77, 1997. View at Publisher · View at Google Scholar · View at Scopus
  4. N. Bruneau, S. Richard, F. Silvy, A. Verine, and D. Lombardo, “Lectin-like Ox-LDL receptor is expressed in human INT-407 intestinal cells: involvement in the transcytosis of pancreatic bile salt-dependent lipase,” Molecular Biology of the Cell, vol. 14, no. 7, pp. 2861–2875, 2003. View at Publisher · View at Google Scholar · View at Scopus
  5. M. Chen, T. Masaki, and T. Sawamura, “LOX-1, the receptor for oxidized low-density lipoprotein identified from endothelial cells: implications in endothelial dysfunction and atherosclerosis,” Pharmacology and Therapeutics, vol. 95, no. 1, pp. 89–100, 2002. View at Publisher · View at Google Scholar · View at Scopus
  6. O. Hofnagel, B. Luechtenborg, K. Stolle et al., “Proinflammatory cytokines regulate LOX-1 expression in vascular smooth muscle cells,” Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 24, no. 10, pp. 1789–1795, 2004. View at Publisher · View at Google Scholar · View at Scopus
  7. C. Scaccini and I. Jialal, “LDL modification by activated polymorphonuclear leukocytes: a cellular model of mild oxidative stress,” Free Radical Biology and Medicine, vol. 16, no. 1, pp. 49–55, 1994. View at Publisher · View at Google Scholar · View at Scopus
  8. M. K. Cathcart, D. W. Morel, and G. M. Chisolm III, “Monocytes and neutrophils oxidize low density lipoprotein making it cytotoxic,” Journal of Leukocyte Biology, vol. 38, no. 2, pp. 341–350, 1985. View at Google Scholar · View at Scopus
  9. E. F. De Assis, A. R. Silva, L. F. C. Caiado et al., “Synergism between platelet-activating factor-like phospholipids and peroxisome proliferator-activated receptor γ agonists generated during low density lipoprotein oxidation that induces lipid body formation in leukocytes,” Journal of Immunology, vol. 171, no. 4, pp. 2090–2098, 2003. View at Google Scholar · View at Scopus
  10. Z. Wu, T. Sawamura, A. K. Kurdowska, H.-L. Ji, S. Idell, and J. Fu, “Lox-1 deletion improves neutrophil responses, enhances bacterial clearance, and reduces lung injury in a murine polymicrobial sepsis model,” Infection and Immunity, vol. 79, no. 7, pp. 2865–2870, 2011. View at Publisher · View at Google Scholar · View at Scopus
  11. P. Zhang, M.-C. Liu, L. Cheng, M. Liang, H.-L. Ji, and J. Fu, “Blockade of LOX-1 prevents endotoxin-induced acute lung inflammation and injury in mice,” Journal of Innate Immunity, vol. 1, no. 4, pp. 358–365, 2009. View at Publisher · View at Google Scholar · View at Scopus
  12. M. Honjo, K. Nakamura, K. Yamashiro et al., “Lectin-like oxidized LDL receptor-1 is a cell-adhesion molecule involved in endotoxin-induced inflammation,” Proceedings of the National Academy of Sciences of the United States of America, vol. 100, no. 3, pp. 1274–1279, 2003. View at Publisher · View at Google Scholar · View at Scopus
  13. J. L. Mehta, J. Chen, P. L. Hermonat, F. Romeo, and G. Novelli, “Lectin-like, oxidized low-density lipoprotein receptor-1 (LOX-1): a critical player in the development of atherosclerosis and related disorders,” Cardiovascular Research, vol. 69, no. 1, pp. 36–45, 2006. View at Publisher · View at Google Scholar · View at Scopus
  14. R. Laczik, P. Szodoray, K. Veres et al., “Oxidized LDL induces in vitro lymphocyte activation in antiphospholipid syndrome,” Autoimmunity, vol. 43, no. 4, pp. 334–339, 2010. View at Publisher · View at Google Scholar · View at Scopus
  15. J. Alcouffe, S. Caspar-Bauguil, V. Garcia, R. Salvayre, M. Thomsen, and H. Benoist, “Oxidized low density lipoproteins induce apoptosis in PHA-activated peripheral blood mononuclear cells and in the Jurkat T-cell line,” Journal of Lipid Research, vol. 40, no. 7, pp. 1200–1210, 1999. View at Google Scholar · View at Scopus
  16. A. Lee -S, J. Wang, H. Chan -C, F. Chen -Y, C. Chang -M, C. Yang et al., “Electronegative low-density lipoprotein induces cardiomyocyte apoptosis through a chemokine-cytokine crosstalk mechanism,” Journal of the American College of Cardiology, vol. 59, no. 13, p. E1000, 2012. View at Google Scholar
  17. C.-Y. Han and Y. K. Pak, “Oxidation-dependent effects of oxidized LDL: proliferation or cell death,” Experimental and Molecular Medicine, vol. 31, no. 4, pp. 165–173, 1999. View at Google Scholar · View at Scopus
  18. H. A. Lehr, J. Seemuller, C. Hubner, M. D. Menger, and K. Messmer, “Oxidized LDL-induced leukocyte/endothelium interaction in vivo involves the receptor for platelet-activating factor,” Arteriosclerosis and Thrombosis, vol. 13, no. 7, pp. 1013–1018, 1993. View at Google Scholar · View at Scopus
  19. T. W. Hein and L. Kuo, “LDLs impair vasomotor function of the coronary microcirculation: role of superoxide anions,” Circulation Research, vol. 83, no. 4, pp. 404–414, 1998. View at Google Scholar · View at Scopus
  20. W.-J. Lee, H.-C. Ou, W.-C. Hsu et al., “Ellagic acid inhibits oxidized LDL-mediated LOX-1 expression, ROS generation, and inflammation in human endothelial cells,” Journal of Vascular Surgery, vol. 52, no. 5, pp. 1290–1300, 2010. View at Google Scholar · View at Scopus
  21. M. Matsumoto, M. Ikeda, M. Seike, and H. Kodama, “Different mechanisms of adhesion molecule expression in human dermal microvascular endothelial cells by xanthoma tissue-mediated and copper-mediated oxidized low density lipoproteins,” Journal of Dermatological Science, vol. 32, no. 1, pp. 43–54, 2003. View at Publisher · View at Google Scholar · View at Scopus
  22. H. H. Shih, S. Zhang, W. Cao et al., “CRP is a novel ligand for the oxidized LDL receptor LOX-1,” American Journal of Physiology, vol. 296, no. 5, pp. H1643–H1650, 2009. View at Publisher · View at Google Scholar · View at Scopus
  23. M. Kakutani, T. Masaki, and T. Sawamura, “A platelet-endothelium interaction mediated by lectin-like oxidized low-density lipoprotein receptor-1,” Proceedings of the National Academy of Sciences of the United States of America, vol. 97, no. 1, pp. 360–364, 2000. View at Google Scholar · View at Scopus
  24. H. Vink, A. A. Constantinescu, and J. A. E. Spaan, “Oxidized lipoproteins degrade the endothelial surface layer: implications for platelet-endothelial cell adhesion,” Circulation, vol. 101, no. 13, pp. 1500–1502, 2000. View at Google Scholar · View at Scopus
  25. L. Liao, T. Y. Aw, P. R. Kvietys, and D. N. Granger, “Oxidized LDL-induced microvascular dysfunction: dependence on oxidation procedure,” Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 15, no. 12, pp. 2305–2311, 1995. View at Google Scholar · View at Scopus
  26. L. Liao and D. N. Granger, “Role of mast cells in oxidized low-density lipoprotein-induced microvascular dysfunction,” American Journal of Physiology, vol. 271, no. 5, pp. H1795–H1800, 1996. View at Google Scholar · View at Scopus
  27. T. Katayama, A. Tanaka-Shiraishi, M. Kiyomura, T. Matsumoto, Y. Kusanagi, and M. Ito, “Effects of oxidized low-density lipoprotein on leukocyte-endothelial interactions in the rat mesenteric microcirculation during pregnancy,” American Journal of Obstetrics and Gynecology, vol. 191, no. 1, pp. 322–327, 2004. View at Publisher · View at Google Scholar · View at Scopus
  28. S. Bhaskar, V. Shalini, and A. Helen, “Quercetin regulates oxidized LDL induced inflammatory changes in human PBMCs by modulating the TLR-NF-κB signaling pathway,” Immunobiology, vol. 216, no. 3, pp. 367–373, 2011. View at Publisher · View at Google Scholar · View at Scopus
  29. L. Cominacini, A. Fratta Pasini, U. Garbin et al., “Oxidized low density lipoprotein (ox-LDL) binding to ox-LDL receptor-1 in endothelial cells induces the activation of NF-κB through an increased production of intracellular reactive oxygen species,” The Journal of Biological Chemistry, vol. 275, no. 17, pp. 12633–12638, 2000. View at Publisher · View at Google Scholar · View at Scopus
  30. P. Wiesner, S.-H. Choi, F. Almazan et al., “Low doses of lipopolysaccharide and minimally oxidized low-density lipoprotein cooperatively activate macrophages via nuclear factor κb and activator protein-1: possible mechanism for acceleration of atherosclerosis by subclinical endotoxemia,” Circulation Research, vol. 107, no. 1, pp. 56–65, 2010. View at Publisher · View at Google Scholar · View at Scopus
  31. T. A. Hamilton, J. A. Major, D. Armstrong, and J. M. Tebo, “Oxidized LDL modulates activation of NFκB in mononuclear phagocytes by altering the degradation of IκBs,” Journal of Leukocyte Biology, vol. 64, no. 5, pp. 667–674, 1998. View at Google Scholar · View at Scopus
  32. F. Robbesyn, R. Salvayre, and A. Negre-Salvayre, “Dual role of oxidized LDL on the NF-κB signaling, pathway,” Free Radical Research, vol. 38, no. 6, pp. 541–551, 2004. View at Publisher · View at Google Scholar · View at Scopus
  33. M. Kusuhara, A. Chait, A. Cader, and B. C. Berk, “Oxidized LDL stimulates mitogen-activated protein kinases in smooth muscle cells and macrophages,” Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 17, no. 1, pp. 141–148, 1997. View at Google Scholar · View at Scopus
  34. R. Terkeltaub, C. L. Banka, J. Solan, D. Santoro, K. Brand, and L. K. Curtiss, “Oxidized LDL induces monocytic cell expression of interleukin-8, a chemokine with T-lymphocyte chemotactic activity,” Arteriosclerosis and Thrombosis, vol. 14, no. 1, pp. 47–53, 1994. View at Google Scholar · View at Scopus
  35. M. D. Mattaliano, C. Huard, W. Cao et al., “LOX-1-dependent transcriptional regulation in response to oxidized LDL treatment of human aortic endothelial cells,” American Journal of Physiology, vol. 296, no. 6, pp. C1329–C1337, 2009. View at Publisher · View at Google Scholar · View at Scopus
  36. M. Akagi, A. Ueda, T. Teramura, S. Kanata, T. Sawamura, and C. Hamanishi, “Oxidized LDL binding to LOX-1 enhances MCP-1 expression in cultured human articular chondrocytes,” Osteoarthritis and Cartilage, vol. 17, no. 2, pp. 271–275, 2009. View at Publisher · View at Google Scholar · View at Scopus
  37. J. Frostegard, Y. H. Huang, J. Ronnelid, and L. Schafer-Elinder, “Platelet-activating factor and oxidized LDL induce immune activation by a common mechanism,” Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 17, pp. 963–968, 1997. View at Publisher · View at Google Scholar
  38. L. Cominacini, A. Rigoni, A. F. Pasini et al., “The binding of oxidized low density lipoprotein (ox-LDL) to ox-LDL receptor-1 reduces the intracellular concentration of nitric oxide in endothelial cells through an increased production of superoxide,” The Journal of Biological Chemistry, vol. 276, no. 17, pp. 13750–13755, 2001. View at Google Scholar · View at Scopus
  39. T. B. Rajavashisth, J. K. Liao, Z. S. Galis et al., “Inflammatory cytokines and oxidized low density lipoproteins increase endothelial cell expression of membrane type 1-matrix metalloproteinase,” The Journal of Biological Chemistry, vol. 274, no. 17, pp. 11924–11929, 1999. View at Publisher · View at Google Scholar · View at Scopus
  40. K. Oka, T. Sawamura, K.-I. Kikuta et al., “Lectin-like oxidized low-density lipoprotein receptor 1 mediates phagocytosis of aged/apoptotic cells in endothelial cells,” Proceedings of the National Academy of Sciences of the United States of America, vol. 95, no. 16, pp. 9535–9540, 1998. View at Publisher · View at Google Scholar · View at Scopus
  41. S. Parlato, G. Romagnoli, F. Spadaro et al., “LOX-1 as a natural IFN-α-mediated signal for apoptotic cell uptake and antigen presentation in dendritic cells,” Blood, vol. 115, no. 8, pp. 1554–1563, 2010. View at Publisher · View at Google Scholar · View at Scopus