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Mediators of Inflammation
Volume 2013, Article ID 850714, 7 pages
http://dx.doi.org/10.1155/2013/850714
Clinical Study

Prognostic Value of Inflammatory Mediators in 1-Year Outcome of Acute Ischemic Stroke with Middle Cerebral Artery Stenosis

1Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, No. 6 Tiantan Xili, Dongcheng District, Beijing 100050, China
2Division of Neurology, Department of Medicine & Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong, China

Received 22 February 2013; Revised 10 July 2013; Accepted 15 July 2013

Academic Editor: Dennis D. Taub

Copyright © 2013 Xiping Gong et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. A. Tuttolomondo, D. Di Raimondo, R. Pecoraro, V. Arnao, A. Pinto, and G. Licata, “Atherosclerosis as an inflammatory disease,” Current Pharmaceutical Design, vol. 18, pp. 4266–4288, 2012. View at Google Scholar
  2. M. T. Montero-Vega, “The inflammatory process underlying atherosclerosis,” Critical Reviews in Immunology, vol. 32, pp. 373–462, 2012. View at Google Scholar
  3. A. Anogeianaki, D. Angelucci, E. Cianchetti et al., “Atherosclerosis: a classic inflammatory disease,” International Journal of Immunopathology and Pharmacology, vol. 24, no. 4, pp. 817–825, 2011. View at Google Scholar · View at Scopus
  4. P. Libby, “Inflammation in atherosclerosis,” Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 32, pp. 2045–2051, 2012. View at Google Scholar
  5. J. M. Simard, T. A. Kent, M. Chen, K. V. Tarasov, and V. Gerzanich, “Brain oedema in focal ischaemia: molecular pathophysiology and theoretical implications,” Lancet Neurology, vol. 6, no. 3, pp. 258–268, 2007. View at Publisher · View at Google Scholar · View at Scopus
  6. J. E. Jung, G. S. Kim, H. Chen et al., “Reperfusion and neurovascular dysfunction in stroke: from basic mechanisms to potential strategies for neuroprotection,” Molecular Neurobiology, vol. 41, no. 2-3, pp. 172–179, 2010. View at Publisher · View at Google Scholar · View at Scopus
  7. J. N. Stankowski and R. Gupta, “Therapeutic targets for neuroprotection in acute ischemic stroke: lost in translation?” Antioxidants and Redox Signaling, vol. 14, no. 10, pp. 1841–1851, 2011. View at Publisher · View at Google Scholar · View at Scopus
  8. W. Whiteley, C. Jackson, S. Lewis et al., “Inflammatory markers and poor outcome after stroke: a prospective cohort study and systematic review of interleukin-6,” PLoS Medicine, vol. 6, no. 9, Article ID e1000145, 2009. View at Publisher · View at Google Scholar · View at Scopus
  9. T. H. Wu, K. L. Chien, H. J. Lin et al., “Total white blood cell count or neutrophil count predict ischemic stroke events among adult Taiwanese: report from a community-based cohort study,” BMC Neurology, vol. 13, article 7, 2013. View at Google Scholar
  10. R. Kazmierski, P. Guzik, W. Ambrosius, A. Ciesielska, J. Moskal, and W. Kozubski, “Predictive value of white blood cell count on admission for in-hospital mortality in acute stroke patients,” Clinical Neurology and Neurosurgery, vol. 107, no. 1, pp. 38–43, 2004. View at Publisher · View at Google Scholar · View at Scopus
  11. A. J. Grau, A. W. Boddy, D. A. Dukovic et al., “Leukocyte count as an independent predictor of recurrent ischemic events,” Stroke, vol. 35, no. 5, pp. 1147–1152, 2004. View at Publisher · View at Google Scholar · View at Scopus
  12. W. Zhang, K. Sun, J. Chen et al., “High plasma homocysteine levels contribute to the risk of stroke recurrence and all-cause mortality in a large prospective stroke population,” Clinical Science, vol. 118, no. 3, pp. 187–194, 2010. View at Publisher · View at Google Scholar · View at Scopus
  13. R. Cui, Y. Moriyama, K. A. Koike et al., “Serum total homocysteine concentrations and risk of mortality from stroke and coronary heart disease in Japanese: The JACC study,” Atherosclerosis, vol. 198, no. 2, pp. 412–418, 2008. View at Publisher · View at Google Scholar · View at Scopus
  14. J. Yan, J. K. Liao, and D. Wang, “Elevated homocysteine and C-reactive protein levels independently predict worsening prognosis after stroke in Chinese patients,” Journal of Huazhong University of Science and Technology, vol. 30, pp. 643–647, 2010. View at Google Scholar
  15. X. Q. Wu, J. Ding, A. Y. Ge, F. F. Liu, X. Wang, and W. Fan, “Acute phase homocysteine related to severity and outcome of atherothrombotic stroke,” European Journal of Internal Medicine, vol. 24, pp. 362–367, 2013. View at Google Scholar
  16. H. M. Den Hertog, J. A. Van Rossum, H. B. Van Der Worp et al., “C-reactive protein in the very early phase of acute ischemic stroke: association with poor outcome and death,” Journal of Neurology, vol. 256, no. 12, pp. 2003–2008, 2009. View at Publisher · View at Google Scholar · View at Scopus
  17. S. Shantikumar, P. J. Grant, A. J. Catto, J. M. Bamford, and A. M. Carter, “Elevated C-reactive protein and long-term mortality after ischaemic stroke relationship with markers of endothelial cell and platelet activation,” Stroke, vol. 40, no. 3, pp. 977–979, 2009. View at Publisher · View at Google Scholar · View at Scopus
  18. M. Di Napoli, F. Papa, and V. Bocola, “C-reactive protein in ischemic stroke an independent prognostic factor,” Stroke, vol. 32, no. 4, pp. 917–924, 2001. View at Google Scholar · View at Scopus
  19. O. B. Samuels, G. J. Joseph, M. J. Lynn, H. A. Smith, and M. I. Chimowitz, “A standardized method for measuring intracranial arterial stenosis,” American Journal of Neuroradiology, vol. 21, no. 4, pp. 643–646, 2000. View at Google Scholar · View at Scopus
  20. P. T. Akins, T. K. Pilgram, D. T. Cross 3rd, and C. J. Moran, “Natural history of stenosis from intracranial atherosclerosis by serial angiography,” Stroke, vol. 29, no. 2, pp. 433–438, 1998. View at Google Scholar · View at Scopus
  21. L. Mannini, R. Marcucci, R. Paniccia et al., “Erythrocyte deformability and white blood cell count are associated with aspirin resistance in high-risk vascular patients,” Clinical Hemorheology and Microcirculation, vol. 35, no. 1-2, pp. 175–181, 2006. View at Google Scholar · View at Scopus
  22. E. Grad, M. Golomb, N. Koroukhov et al., “Aspirin reduces the prothrombotic activity of C-reactive protein,” Journal of Thrombosis and Haemostasis, vol. 7, no. 8, pp. 1393–1400, 2009. View at Publisher · View at Google Scholar · View at Scopus
  23. M. W. McCarthy, D. Kockler, J. F. Feliú, and J. Kaiser, “Clopidogrel-associated leukopenia,” Annals of Pharmacotherapy, vol. 37, no. 2, pp. 216–219, 2003. View at Google Scholar · View at Scopus
  24. M. A. Albert, E. Danielson, N. Rifai, and P. M. Ridker, “Effect of statin therapy on C-reactive protein levels: the pravastatin inflammation/CRP evaluation (PRINCE): A randomized trial and cohort study,” Journal of the American Medical Association, vol. 286, no. 1, pp. 64–70, 2001. View at Google Scholar · View at Scopus
  25. E. Lonn, S. Yusuf, M. J. Arnold et al., “Homocysteine lowering with folic acid and B vitamins in vascular disease,” The New England Journal of Medicine, vol. 354, no. 15, pp. 1567–1577, 2006. View at Publisher · View at Google Scholar · View at Scopus
  26. S. Kaptoge, E. Di Angelantonio, G. Lowe et al., “C-reactive protein concentration and risk of coronary heart disease, stroke, and mortality: an individual participant meta-analysis,” The Lancet, vol. 375, pp. 132–140, 2010. View at Google Scholar
  27. K. Winbeck, H. Poppert, T. Etgen, B. Conrad, and D. Sander, “Prognostic relevance of early serial C-reactive protein measurements after first ischemic stroke,” Stroke, vol. 33, no. 10, pp. 2459–2464, 2002. View at Publisher · View at Google Scholar · View at Scopus
  28. K. H. Bønaa, I. Njølstad, P. M. Ueland et al., “Homocysteine lowering and cardiovascular events after acute myocardial infarction,” The New England Journal of Medicine, vol. 354, no. 15, pp. 1578–1588, 2006. View at Publisher · View at Google Scholar · View at Scopus
  29. M. Ebbing, Ø. Bleie, P. M. Ueland et al., “Mortality and cardiovascular events in patients treated with homocysteine-lowering B vitamins after coronary angiography: A randomized controlled trial,” Journal of the American Medical Association, vol. 300, no. 7, pp. 795–804, 2008. View at Publisher · View at Google Scholar · View at Scopus
  30. J. A. Jakubowski, C. B. Thompson, and R. Vaillancourt, “Arachidonic acid metabolism by platelets of differing size,” British Journal of Haematology, vol. 53, no. 3, pp. 503–511, 1983. View at Google Scholar · View at Scopus
  31. J. C. Arevalo-Lorido, J. Carretero-Gomez, A. Alvarez-Oliva, C. Gutierrez-Montano, J. M. Fernandez-Recio, and F. Najarro-Diez, “Mean platelet volume in acute phase of ischemic stroke, as predictor of mortality and functional outcome after 1 year,” Journal of Stroke and Cerebrovascular Diseases, vol. 22, no. 4, pp. 297–303, 2013. View at Publisher · View at Google Scholar
  32. S. Greisenegger, G. Endler, K. Hsieh, S. Tentschert, C. Mannhalter, and W. Lalouschek, “Is elevated mean platelet volume associated with a worse outcome in patients with acute ischemic cerebrovascular events?” Stroke, vol. 35, no. 7, pp. 1688–1691, 2004. View at Publisher · View at Google Scholar · View at Scopus
  33. M. Y. Z. Youssef, O. A. Mojiminiyi, and N. A. Abdella, “Plasma concentrations of C-reactive protein and total homocysteine in relation to the severity and risk factors for cerebrovascular disease,” Translational Research, vol. 150, no. 3, pp. 158–163, 2007. View at Publisher · View at Google Scholar · View at Scopus