Table of Contents Author Guidelines Submit a Manuscript
Mediators of Inflammation
Volume 2013, Article ID 942375, 15 pages
http://dx.doi.org/10.1155/2013/942375
Review Article

Role of Macrophages in the Pathogenesis of Atopic Dermatitis

1Global Preclinical Drug Discovery, Department of Molecular Pharmacology, Grünenthal GmbH, Zieglerstrße 6, 52078 Aachen, Germany
2Division of Immunodermatology and Allergy Research, Department of Dermatology and Allergy, Hannover Medical School, 30625 Hannover, Germany

Received 15 October 2012; Revised 17 January 2013; Accepted 18 January 2013

Academic Editor: Chiou-Feng Lin

Copyright © 2013 Sadaf Kasraie and Thomas Werfel. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Citations to this Article [38 citations]

The following is the list of published articles that have cited the current article.

  • Bodo C. Melnik, “Does therapeutic intervention in atopic dermatitis normalize epidermal Notch deficiency?,” Experimental Dermatology, 2014. View at Publisher · View at Google Scholar
  • D. Pin, M. Bekrich, O. Fantini, G. Noel, and E. Vidémont, “An Emulsion Restores the Skin Barrier by Decreasing the Skin pH and Inflammation in a Canine Experimental Model,” Journal of Comparative Pathology, 2014. View at Publisher · View at Google Scholar
  • Kazuma Higashisaka, Maho Fujimura, Mayu Taira, Tokuyuki Yoshida, Shin-ichi Tsunoda, Takashi Baba, Nobuyasu Yamaguchi, Hiromi Nabeshi, Tomoaki Yoshikawa, Masao Nasu, Yasuo Yoshioka, and Yasuo Tsutsumi, “Asian Dust Particles Induce Macrophage Inflammatory Responses via Mitogen-Activated Protein Kinase Activation and Reactive Oxygen Species Production,” Journal of Immunology Research, vol. 2014, pp. 1–9, 2014. View at Publisher · View at Google Scholar
  • María Matabuena de Yzaguirre, Gabriela Bacchini, Emili Gil Luna, and Eva Vila-Martínez, “Anti-Inflammatory Efficacy of Product Containing “Skin Calm Complex” <i>in Vitro</i> Reconstructed Epidermis,” Journal of Cosmetics, Dermatological Sciences and Applications, vol. 04, no. 05, pp. 309–315, 2014. View at Publisher · View at Google Scholar
  • Karyn A Haitz, and Niroshana Anandasabapathy, “Docosahexaenoic Acid Alleviates Atopic Dermatitis in Mice by Generating T Regulatory Cells and M2 Macrophages,” Journal of Investigative Dermatology, vol. 135, no. 6, pp. 1472–1474, 2015. View at Publisher · View at Google Scholar
  • Dahae Lim, Min Kyoung Kim, Young-Pyo Jang, and Jinju Kim, “Sceptridium ternatum attenuates allergic contact dermatitis-like skin lesions by inhibiting T helper 2-type immune responses and inflammatory responses in a mouse model,” Journal of Dermatological Science, 2015. View at Publisher · View at Google Scholar
  • Eun Joo Park, Ji-Yun Kim, Mi Sook Jeong, Kui Young Park, Kwan Hee Park, Min Won Lee, Seong Soo Joo, and Seong Jun Seo, “Effect of topical application of quercetin-3-O-(2″-gallate)-α-l-rhamnopyranoside on atopic dermatitis in NC/Nga mice,” Journal of Dermatological Science, vol. 77, no. 3, pp. 166–172, 2015. View at Publisher · View at Google Scholar
  • Purnima Kumar, Md Zahangir Hosain, Jeong-Hun Kang, Masafumi Takeo, Akihiro Kishimura, Takeshi Mori, and Yoshiki Katayama, “Suppression of atopic dermatitis in mice model by reducing inflammation utilizing phosphatidylserine-coated biodegradable microparticles,” Journal Of Biomaterials Science-Polymer Edition, vol. 26, no. 18, pp. 1465–1474, 2015. View at Publisher · View at Google Scholar
  • Julia Kzhyshkowska, Alexandru Gudima, Vladimir Riabov, Camille Dollinger, Philippe Lavalle, and Nihal Engin Vrana, “Macrophage responses to implants: prospects for personalized medicine,” Journal Of Leukocyte Biology, vol. 98, no. 6, pp. 953–962, 2015. View at Publisher · View at Google Scholar
  • Bodo C. Melnik, “The Potential Role of Impaired Notch Signalling in Atopic Dermatitis,” Acta Dermato-Venereologica, vol. 95, no. 1, pp. 5–11, 2015. View at Publisher · View at Google Scholar
  • Muhammad Akram, Iljin Shin, Kyeong-A Kim, Dabi Noh, Seung-Hoon Baek, Sun-Young Chang, Hyoungsu Kim, and Ok-Nam Bae, “A newly synthesized macakurzin C-derivative attenuates acute and chronic skin inflammation: the Nrf2/heme oxygenase signaling as a potential target,” Toxicology and Applied Pharmacology, 2016. View at Publisher · View at Google Scholar
  • Vedastus W. Makene, Jimoh O. Tijani, Leslie F. Petrik, and Edmund J. Pool, “Evaluation of cytotoxicity and inflammatory activity of wastewater collected from a textile factory before and after treatment by coagulation-flocculation methods,” Environmental Monitoring and Assessment, vol. 188, no. 8, 2016. View at Publisher · View at Google Scholar
  • So Jin Bing, Jinhee Cho, Areum Kim, Sumin Shin, Gi-Ok Kim, Jong-chul Lee, and Youngheun Jee, “Anti-inflammatory activities of Dangyuja (Citrus grandis Osbeck) in concanavalin A stimulated murine splenocytes and 12-O-tetradecanoylphorbol-13-acetate-induced murine skin edema,” Biomedicine & Pharmacotherapy, vol. 83, pp. 1353–1364, 2016. View at Publisher · View at Google Scholar
  • M R López-Álvarez, W Jiang, D C Jones, J Jayaraman, C Johnson, W O Cookson, M F Moffatt, J Trowsdale, and J A Traherne, “LILRA6 copy number variation correlates with susceptibility to atopic dermatitis.,” Immunogenetics, vol. 68, no. 9, pp. 743–7, 2016. View at Publisher · View at Google Scholar
  • In Jun Yang, Dong-Ung Lee, and Heung Mook Shin, “Inhibitory Effect of Valencene on the Development of Atopic Dermatitis-Like Skin Lesions in NC/Nga Mice,” Evidence-Based Complementary and Alternative Medicine, vol. 2016, pp. 1–11, 2016. View at Publisher · View at Google Scholar
  • Olusiji A. Akinrinmade, Shivan Chetty, Adebukola K. Daramola, Mukit-ul Islam, Theo Thepen, and Stefan Barth, “CD64: An Attractive Immunotherapeutic Target for M1-type Macrophage Mediated Chronic Inflammatory Diseases,” Biomedicines, vol. 5, no. 3, pp. 56, 2017. View at Publisher · View at Google Scholar
  • Hui Weng, Jian Fei Song, Yong Wang, Yun Hua Deng, Shuang Li, and Hong Bo Liu, “Activation of the HMGB1-TLR4-NF-κB pathway may occur in patients with atopic eczema,” Molecular Medicine Reports, vol. 16, no. 3, pp. 2714–2720, 2017. View at Publisher · View at Google Scholar
  • Susanne Mommert, Karl Gregor, Kristine Rossbach, Katrin Schaper, Torsten Witte, Ralf Gutzmer, and Thomas Werfel, “Histamine H2 receptor stimulation upregulates T H 2 chemokine CCL17 production in human M2a macrophages,” Journal of Allergy and Clinical Immunology, 2017. View at Publisher · View at Google Scholar
  • Thressi Maxwell, Kyu-Shik Lee, So-Young Chun, and Kyung-Soo Nam, “Mineral-balanced deep sea water enhances the inhibitory effects of chitosan oligosaccharide on atopic dermatitis-like inflammatory response,” Biotechnology and Bioprocess Engineering, vol. 22, no. 2, pp. 120–128, 2017. View at Publisher · View at Google Scholar
  • Aishath S. Naeem, Cristina Tommasi, Christian Cole, Stuart J. Brown, Yanan Zhu, Benjamin Way, Saffron A.G. Willis Owen, Miriam Moffatt, William O. Cookson, John I. Harper, Wei-Li Di, Sara J. Brown, Thomas Reinheckel, and Ryan F.L. O'Shaughnessy, “A mechanistic target of rapamycin complex 1/2 (mTORC1)/V-Akt murine thymoma viral oncogene homolog 1 (AKT1)/cathepsin H axis controls filaggrin expression and processing in skin, a novel mechanism for skin barrier disruption in patients with atopic dermatitis,” Journal of Allergy and Clinical Immunology, vol. 139, no. 4, pp. 1228–1241, 2017. View at Publisher · View at Google Scholar
  • Kely Campos Navegantes, Rafaelli de Souza Gomes, Priscilla Aparecida Tártari Pereira, Paula Giselle Czaikoski, Carolina Heitmann Mares Azevedo, and Marta Chagas Monteiro, “Immune modulation of some autoimmune diseases: the critical role of macrophages and neutrophils in the innate and adaptive immunity,” Journal of Translational Medicine, vol. 15, no. 1, 2017. View at Publisher · View at Google Scholar
  • Ilja Ovsiy, Vladimir Riabov, Ioannis Manousaridis, Julia Michel, Kondaiah Moganti, Shuiping Yin, Tengfei Liu, Carsten Sticht, Elisabeth Kremmer, Martin C. Harmsen, Sergij Goerdt, Alexei Gratchev, and Julia Kzhyshkowska, “IL-4 driven transcription factor FoxQ1 is expressed by monocytes in atopic dermatitis and stimulates monocyte migration,” Scientific Reports, vol. 7, no. 1, 2017. View at Publisher · View at Google Scholar
  • O. Sasso, M. Summa, A. Armirotti, S. Pontis, C. De Mei, and Daniele Piomelli, “The N-Acylethanolamine Acid Amidase Inhibitor ARN077 Suppresses Inflammation and Pruritus in a Mouse Model of Allergic Dermatitis,” Journal of Investigative Dermatology, 2017. View at Publisher · View at Google Scholar
  • Na-Jin Kang, Sang-Chul Han, Hyun-Jae Kang, Geum Ko, Weon-Jong Yoon, Hee-Kyoung Kang, and Eun-Sook Yoo, “ Anti-Inflammatory Effect of 3-Bromo-4,5-Dihydroxybenzaldehyde, a Component of Polysiphonia morrowii , In Vivo and In Vitro ,” Toxicological Research, vol. 33, no. 4, pp. 325–332, 2017. View at Publisher · View at Google Scholar
  • Alexander B. Sigalov, “Targeting Intramembrane Protein–Protein Interactions: Novel Therapeutic Strategy of Millions Years Old,” 2017. View at Publisher · View at Google Scholar
  • Oki Suwarsa, Sudigdo Adi, Ponpon Idjradinata, Endang Sutedja, Erda Avriyanti, Adlina Asfara, and Hendra Gunawan, “Interleukin-18 correlates with interleukin-4 but not interferon-γ production in lymphocyte cultures from atopic dermatitis patients after staphylococcal enterotoxin B stimulation,” Asian Pacific Journal of Allergy and Immunology, vol. 35, no. 1, pp. 54–59, 2017. View at Publisher · View at Google Scholar
  • Susanne Mommert, Lisanne Ratz, Holger Stark, Ralf Gutzmer, and Thomas Werfel, “The histamine H4 receptor modulates the differentiation process of human monocyte-derived M1 macrophages and the release of CCL4/MIP-1β from fully differentiated M1 macrophages,” Inflammation Research, pp. 1–11, 2018. View at Publisher · View at Google Scholar
  • Stefanie Eyerich, Kilian Eyerich, Claudia Traidl-Hoffmann, and Tilo Biedermann, “Cutaneous Barriers and Skin Immunity: Differentiating A Connected Network,” Trends in Immunology, 2018. View at Publisher · View at Google Scholar
  • Debajyoti Ghosh, Jonathan A. Bernstein, Gurjit K. Khurana Hershey, Marc E. Rothenberg, and Tesfaye B. Mersha, “Leveraging Multilayered “Omics” Data for Atopic Dermatitis: A Road Map to Precision Medicine,” Frontiers in Immunology, vol. 9, 2018. View at Publisher · View at Google Scholar
  • Minglei Wei, Wei Zhu, and Shiwei Lin, “Molecular mechanisms of the anti-inflammatory effect of sinomenine on atopic dermatitis,” Pharmazie, vol. 73, no. 8, pp. 474–476, 2018. View at Publisher · View at Google Scholar
  • Tatyana Gavrilova, “Immune Dysregulation in the Pathogenesis of Atopic Dermatitis,” Dermatitis, vol. 29, no. 2, pp. 57–62, 2018. View at Publisher · View at Google Scholar
  • Sonja Rittchen, and Akos Heinemann, “Therapeutic Potential of Hematopoietic Prostaglandin D2 Synthase in Allergic Inflammation,” Cells, vol. 8, no. 6, pp. 619, 2019. View at Publisher · View at Google Scholar
  • Deok-Hyun Kim, and Ho-Sueb Song, “Atopic Dermatitis-Related Inflammation in Macrophages and Keratinocytes: The Inhibitory Effects of Bee Venom,” Journal of Acupuncture Research, vol. 36, no. 2, pp. 80–87, 2019. View at Publisher · View at Google Scholar
  • Oindrila Bhattacharjee, Uttkarsh Ayyangar, Ambika S. Kurbet, Driti Ashok, and Srikala Raghavan, “Unraveling the ECM-Immune Cell Crosstalk in Skin Diseases,” Frontiers in Cell and Developmental Biology, vol. 7, 2019. View at Publisher · View at Google Scholar
  • Ha-Yeon Song, Woo Sik Kim, Sajid Mushtaq, Ji Min Park, Sung-Hyun Choi, Jae-Woo Cho, Seung-Taik Lim, and Eui-Baek Byun, “A novel chrysin derivative produced by gamma irradiation attenuates 2,4-dinitrochlorobenzene-induced atopic dermatitis-like skin lesions in Balb/c mice,” Food and Chemical Toxicology, 2019. View at Publisher · View at Google Scholar
  • Yelizaveta Torosyan, Hannah Spece, Norman Goodacre, Yasameen Azarbaijani, Danica Marinac‐Dabic, and Steven M. Kurtz, “ In silico approaches for enhancing retrieval analysis as a source for discovery of implant reactivity‐related mechanisms and biomarkers ,” Journal of Biomedical Materials Research Part B: Applied Biomaterials, 2019. View at Publisher · View at Google Scholar
  • Sagar Uttarkar, Nicolo Costantino Brembilla, and Wolf-Henning Boehncke, “Regulatory cells in the skin: Pathophysiologic role and potential targets for anti-inflammatory therapies,” Journal of Allergy and Clinical Immunology, 2019. View at Publisher · View at Google Scholar
  • Tae Kim, Young Cho, HoonGyu Park, Tae Lee, and Hakwon Kim, “Comparison of the Inhibitory Activities of 5,6-Dihydroergosterol Glycoside α- and β-Anomers on Skin Inflammation,” Molecules, vol. 24, no. 2, pp. 371, 2019. View at Publisher · View at Google Scholar