Ubiquitous Transgenic Overexpression of C-C Chemokine Ligand 2: A Model to Assess the Combined Effect of High Energy Intake and Continuous Low-Grade Inflammation

Figure 8

Dietary fat (right column) and CCL2 expression modify the size, number, and morphology of liver macrophages with respect to those fed a chow diet (left column) as assessed with F4/80 staining. Values for stained area and length of macrophages ((a)–(d)) are illustrated with representative microphotographs from transgenic ((e), (f)), WT ((g), (h)) and KO mice ((i), (j)).