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Mediators of Inflammation
Volume 2014, Article ID 362605, 6 pages
Review Article

Immune Evasion Strategies of Pre-Erythrocytic Malaria Parasites

Department of Pathogenic Biology, Third Military Medical University, Chongqing 400038, China

Received 8 January 2014; Revised 25 March 2014; Accepted 27 March 2014; Published 7 May 2014

Academic Editor: Mauricio M. Rodrigues

Copyright © 2014 Hong Zheng et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Malaria is a mosquito-borne infectious disease of humans. It begins with a bite from an infected female Anopheles mosquito and leads to the development of the pre-erythrocytic and blood stages. Blood-stage infection is the exclusive cause of clinical symptoms of malaria. In contrast, the pre-erythrocytic stage is clinically asymptomatic and could be an excellent target for preventive therapies. Although the robust host immune responses limit the development of the liver stage, malaria parasites have also evolved strategies to suppress host defenses at the pre-erythrocytic stage. This paper reviews the immune evasion strategies of malaria parasites at the pre-erythrocytic stage, which could provide us with potential targets to design prophylactic strategies against malaria.