Table of Contents Author Guidelines Submit a Manuscript
Mediators of Inflammation
Volume 2014, Article ID 484280, 5 pages
http://dx.doi.org/10.1155/2014/484280
Review Article

Bone Remodelling Markers in Rheumatoid Arthritis

1Department of Rheumatology, Hôpital Nord, Place Victor Pauchet, 80054 Amiens, France
2INSERM U1088, 1 rue des Louvels, 80000 Amiens, France

Received 23 October 2013; Revised 2 February 2014; Accepted 3 February 2014; Published 15 April 2014

Academic Editor: Frédérique Ponchel

Copyright © 2014 Patrice Fardellone et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. G. Hougeberg, M. C. Lodder, W. F. Lems et al., “Hand cortical bone mass and its associations with radiographic joint damage and fractures in 50–70 year old female patients with rheumatoid arthritis: cross sectional Oslo-Truro-Amsterdam (OSTRA) collaborative study,” Annals of the Rheumatic Diseases, vol. 63, no. 10, pp. 1331–1334, 2004. View at Publisher · View at Google Scholar · View at Scopus
  2. M. C. Lodder, G. Haugeberg, W. F. Lems et al., “Radiographic damage associated with low bone mineral density and vertebral deformities in rheumatoid arthritis: the Oslo-Truro-Amsterdam (OSTRA) collaborative study,” Arthritis Care and Research, vol. 49, no. 2, pp. 209–215, 2003. View at Google Scholar · View at Scopus
  3. H. Forsblad d'Elia, A. Larsen, E. Waltbrand et al., “Radiographic joint destruction in postmenopausal rheumatoid arthritis is strongly associated with generalised osteoporosis,” Annals of the Rheumatic Diseases, vol. 62, no. 7, pp. 617–623, 2003. View at Publisher · View at Google Scholar · View at Scopus
  4. T. Jensen, M. Hansen, K. E. Jensen, J. Podenphant, T. M. Hansen, and L. Hyldstrup, “Comparison of dual X-ray absorptiometry (DXA), digital X-ray radiogrammetry (DXR), and conventional radiographs in the evaluation of osteoporosis and bone erosions in patients with rheumatoid arthritis,” Scandinavian Journal of Rheumatology, vol. 34, no. 1, pp. 27–33, 2005. View at Publisher · View at Google Scholar · View at Scopus
  5. A. Stewart, L. M. Mackenzie, A. J. Black, and D. M. Reid, “Predicting erosive disease in rheumatoid arthritis. A longitudinal study of changes in bone density using digital X-ray radiogrammetry: a pilot study,” Rheumatology, vol. 43, no. 12, pp. 1561–1564, 2004. View at Publisher · View at Google Scholar · View at Scopus
  6. M. J. Green and A. A. Deodhar, “Bone changes in early rheumatoid arthritis,” Best Practice and Research: Clinical Rheumatology, vol. 15, no. 1, pp. 105–123, 2001. View at Publisher · View at Google Scholar · View at Scopus
  7. W. J. Boyle, W. S. Simonet, and D. L. Lacey, “Osteoclast differentiation and activation,” Nature, vol. 423, no. 6937, pp. 337–342, 2003. View at Publisher · View at Google Scholar · View at Scopus
  8. L. C. Hofbauer, C. A. Kuhne, and V. Viereck, “The OPG/RANKL/RANK system in metabolic bone diseases,” Journal of Musculoskeletal & Neuronal Interactions, vol. 4, no. 3, pp. 268–275, 2004. View at Google Scholar · View at Scopus
  9. L. C. Hofbauer, D. L. Lacey, C. R. Dunstan, T. C. Spelsberg, B. L. Riggs, and S. Khosla, “Interleukin-1β and tumor necrosis factor-α, but not interleukin-6, stimulate osteoprotegerin ligand gene expression in human osteoblastic cells,” Bone, vol. 25, no. 3, pp. 255–259, 1999. View at Publisher · View at Google Scholar · View at Scopus
  10. M. C. Bezerra, J. F. Carvalho, A. S. Prokopowitsch, and R. M. Pereira, “RANK, RANKL and osteoprotegerin in arthritic bone loss,” Brazilian Journal of Medical and Biological Research, vol. 38, no. 2, pp. 161–170, 2005. View at Google Scholar · View at Scopus
  11. C. Barnabe and D. A. Hanley, “Effect of tumor necrosis factor alpha inhibition on bone density and turnover markers in patients with rheumatoid arthritis and spondyloarthropathy,” Seminars in Arthritis and Rheumatism, vol. 39, no. 2, pp. 116–122, 2009. View at Publisher · View at Google Scholar · View at Scopus
  12. R. Sakthiswary and S. Das, “The effects of TNF α antagonist therapy on bone metabolism in rheumatoid arthritis: a systematic review,” Current Drug Targets, vol. 14, no. 13, pp. 1552–1557, 2013. View at Publisher · View at Google Scholar
  13. L. H. van Tuyl, A. E. Voskuyl, M. Boers et al., “Baseline RANKL: OPG ratio and markers of bone and cartilage degradation predict annual radiological progression over 11 years in rheumatoid arthritis,” Annals of the Rheumatic Diseases, vol. 69, no. 9, pp. 1623–1628, 2010. View at Publisher · View at Google Scholar · View at Scopus
  14. I. Gonzales-Alvaro, A. M. Ortiz, E. G. Tomero et al., “Baseline serum RANKL levels may serve to predict remission in rheumatoid arthritis patients treated with TNF antagonists,” Annals of the Rheumatic Diseases, vol. 66, no. 12, pp. 1675–1678, 2007. View at Publisher · View at Google Scholar · View at Scopus
  15. A. I. Catrina, E. Af Klint, S. Ernestam et al., “Anti-tumor necrosis factor therapy increases synovial osteoprotegerin expression in rheumatoid arthritis,” Arthritis & Rheumatism, vol. 54, no. 1, pp. 76–81, 2006. View at Publisher · View at Google Scholar · View at Scopus
  16. R. K. Dore, S. B. Cohen, N. E. Lane et al., “Effects of denosumab on bone mineral density and bone turnover in patients with rheumatoid arthritis receiving concurrent glucocorticoids or bisphosphonates,” Annals of the Rheumatic Diseases, vol. 69, no. 5, pp. 872–875, 2010. View at Publisher · View at Google Scholar · View at Scopus
  17. G. R. Heiland, K. Zwerina, W. Baum et al., “Neutralisation of Dkk-1 protects from systemic bone loss during inflammation and reduces sclerostin expression,” Annals of the Rheumatic Diseases, vol. 69, no. 12, pp. 2152–2159, 2010. View at Publisher · View at Google Scholar · View at Scopus
  18. P. Garnero, N. Charni-Tabassi, and N. Voorzanger-Rousselot, “Circulating dickkopf-1 and radiological progression in patients with early rheumatoid arthritis treated with etanercept,” The Journal of Rheumatology, vol. 35, no. 12, pp. 2313–2315, 2008. View at Publisher · View at Google Scholar · View at Scopus
  19. M. Hashizume, N. Hayakawa, and M. Mihara, “IL-6 trans-signalling directly induces RANKL on fibroblast-like synovial cells and is involved in RANKL induction by TNF-α and IL-17,” Rheumatology, vol. 47, no. 11, pp. 1635–1640, 2008. View at Publisher · View at Google Scholar · View at Scopus
  20. P. K. Wong, J. M. Quinn, N. A. Sims, A. van Nieuwenhuijze, I. K. Campbell, and I. P. Wicks, “Interleukin-6 modulates production of T lymphocyte-derived cytokines in antigen-induced arthritis and drives inflammation-induced osteoclastogenesis,” Arthritis & Rheumatism, vol. 54, no. 1, pp. 158–168, 2006. View at Publisher · View at Google Scholar · View at Scopus
  21. F. Chopin, P. Garnero, A. le Henanff et al., “Long-term effects of infliximab on bone and cartilage turnover markers in patients with rheumatoid arthritis,” Annals of the Rheumatic Diseases, vol. 67, no. 3, pp. 353–357, 2008. View at Publisher · View at Google Scholar · View at Scopus
  22. P. Garnero and P. D. Delmas, “Noninvasive techniques for assessing skeletal changes in inflammatory arthritis: bone biomarkers,” Current Opinion in Rheumatology, vol. 16, no. 4, pp. 428–434, 2004. View at Publisher · View at Google Scholar
  23. E. M. Gravallese, “Bone destruction in arthritis,” Annals of the Rheumatic Diseases, vol. 61, supplement 2, pp. ii84–ii86, 2002. View at Google Scholar · View at Scopus
  24. P. Garnero, R. Landewe, M. Boers et al., “Association of baseline levels of markers of bone and cartilage degradation with long-term progression of joint damage in patients with early rheumatoid arthritis,” Arthritis & Rheumatism, vol. 46, no. 11, pp. 2847–2856, 2002. View at Publisher · View at Google Scholar · View at Scopus
  25. A. Straburzyńska-Lupa, A. Nowak, W. Romanowski, P. Korman, and L. Pilaczyńska-Szcześniak, “A study of the link between bone turnover markers and bone mineral density with inflammation and body mass in postmenopausal women with active rheumatoid arthritis,” Journal of Bone and Mineral Metabolism, vol. 31, no. 2, pp. 169–176, 2013. View at Publisher · View at Google Scholar
  26. A. Szentpetery, M. J. McKenna, B. F. Murray et al., “Periarticular bone gain at proximal interphalangeal joints and changes in bone turnover markers in response to tumor necrosis factor inhibitors in rheumatoid and psoriatic arthritis,” The Journal of Rheumatology, vol. 40, no. 5, pp. 653–662, 2013. View at Publisher · View at Google Scholar
  27. M. Vis, E. A. Havaardsholm, G. Haugeberg et al., “Evaluation of bone mineral density, bone metabolism, osteoprotegerin and receptor activator of the NFκB ligand serum levels during treatment with infliximab in patients with rheumatoid arthritis,” Annals of the Rheumatic Diseases, vol. 65, no. 11, pp. 1495–1499, 2006. View at Publisher · View at Google Scholar · View at Scopus
  28. M. Güler-Yüksel, C. F. Allaart, Y. P. Goekoop-Ruiterman et al., “Changes in hand and generalised bone mineral density in patients with recent-onset rheumatoid arthritis,” Annals of the Rheumatic Diseases, vol. 68, no. 3, pp. 330–336, 2009. View at Publisher · View at Google Scholar · View at Scopus
  29. H. Marotte, B. Pallot-Prades, L. Grange, P. Gaudin, C. Alexandre, and P. Miossec, “A 1-year case-control study in patients with rheumatoid arthritis indicates prevention of loss of bone mineral density in both responders and nonresponders to infliximab,” Arthritis Research & Therapy, vol. 9, no. 3, article R61, 2007. View at Publisher · View at Google Scholar · View at Scopus
  30. B. Seriolo, S. Paolino, A. Sulli, V. Ferretti, and M. Cutolo, “Bone metabolism changes during anti-TNF-α therapy in patients with active rheumatoid arthritis,” Annals of the New York Academy of Sciences, vol. 1069, pp. 420–427, 2006. View at Publisher · View at Google Scholar · View at Scopus
  31. K. Briot, P. Garnero, A. le Henanff, M. Dougados, and C. Roux, “Body weight, body composition, and bone turnover changes in patients with spondyloarthropathy receiving anti-tumour necrosis factor α treatment,” Annals of the Rheumatic Diseases, vol. 64, no. 8, pp. 1137–1140, 2005. View at Publisher · View at Google Scholar · View at Scopus
  32. U. Lange, J. Teichmann, U. Muller-Ladner, and J. Strunk, “Increase in bone mineral density of patients with rheumatoid arthritis treated with anti-TNF-α antibody: a prospective open-label pilot study,” Rheumatology, vol. 44, no. 12, pp. 1546–1548, 2005. View at Publisher · View at Google Scholar · View at Scopus
  33. R. Axmann, C. Böhm, G. Krönke, J. Zwerina, J. Smolen, and G. Schett, “Inhibition of interleukin-6 receptor directly blocks osteoclast formation in vitro and in vivo,” Arthritis & Rheumatism, vol. 60, no. 9, pp. 2747–2756, 2009. View at Publisher · View at Google Scholar · View at Scopus
  34. E. Terpos, K. Fragiadaki, M. Konsta, C. Bratengeier, A. Papatheodorou, and P. P. Sfikakis, “Early effects of IL-6 receptor inhibition on bone homeostasis: a pilot study in women with rheumatoid arthritis,” Clinical and Experimental Rheumatology, vol. 29, no. 6, pp. 921–925, 2011. View at Google Scholar · View at Scopus
  35. P. Garnero, E. Thompson, T. Woodworth, and J. S. Smolen, “Rapid and sustained improvement in bone and cartilage turnover markers with the anti-interleukin-6 receptor inhibitor tocilizumab plus methotrexate in rheumatoid arthritis patients with an inadequate response to methotrexate: results from a substudy of the multicenter double-blind, placebo-controlled trial of tocilizumab in inadequate responders to methotrexate alone,” Arthritis & Rheumatism, vol. 62, no. 1, pp. 33–43, 2010. View at Publisher · View at Google Scholar · View at Scopus
  36. K. Kanbe, A. Nakamura, Y. Inoue, and K. Hobo, “Osteoprotegerin expression in bone marrow by treatment with tocilizumab in rheumatoid arthritis,” Rheumatology International, vol. 32, no. 9, pp. 2669–2674, 2012. View at Publisher · View at Google Scholar · View at Scopus
  37. M. A. Karsdal, G. Schett, P. Emery et al., “IL-6 receptor inhibition positively modulates bone balance in rheumatoid arthritis patients with an inadequate response to anti-tumor necrosis factor therapy: biochemical marker analysis of bone metabolism in the tocilizumab RADIATE study (NCT00106522),” Seminars in Arthritis and Rheumatism, vol. 42, no. 2, pp. 131–139, 2012. View at Publisher · View at Google Scholar · View at Scopus
  38. J. Hashimoto, P. Garnero, D. van der Heijde et al., “Humanized anti-interleukin-6-receptor antibody (tocilizumab) monotherapy is more effective in slowing radiographic progression in patients with rheumatoid arthritis at high baseline risk for structural damage evaluated with levels of biomarkers, radiography, and BMI: data from the SAMURAI study,” Modern Rheumatology, vol. 21, no. 1, pp. 10–15, 2011. View at Publisher · View at Google Scholar · View at Scopus
  39. M. Onal, J. Xiong, X. Chen et al., “Receptor activator of nuclear factor κB ligand (RANKL) protein expression by B lymphocytes contributes to ovariectomy-induced bone loss,” The Journal of Biological Chemistry, vol. 287, pp. 29851–29860, 2012. View at Publisher · View at Google Scholar
  40. G. Hein, T. Eidner, P. Oelzner et al., “Influence of rituximab on markers of bone remodeling in patients with rheumatoid arthritis: a prospective open-label pilot study,” Rheumatology International, vol. 31, no. 2, pp. 269–272, 2011. View at Publisher · View at Google Scholar · View at Scopus
  41. M. J. de Hair, I. A. Zijlstra, M. J. Boumans et al., “Hunting for the pathogenesis of rheumatoid arthritis: core-needle biopsy of inguinal lymph nodes as a new research tool,” Annals of the Rheumatic Diseases, vol. 71, no. 11, pp. 1911–1912, 2012. View at Publisher · View at Google Scholar
  42. G. Hein, T. Eidner, P. Oelzner et al., “Influence of Rituximab on markers of bone remodeling in patients with rheumatoid arthritis: a prospective open-label pilot study,” Rheumatology International, vol. 31, no. 2, pp. 269–272, 2011. View at Publisher · View at Google Scholar · View at Scopus
  43. V. Goëb, M. H. Buch, E. M. Vital, and P. Emery, “Costimulation blockade in rheumatic diseases: where we are?” Current Opinion in Rheumatology, vol. 21, no. 3, pp. 244–250, 2009. View at Publisher · View at Google Scholar
  44. R. Axmann, S. Herman, M. Zaiss et al., “CTLA-4 directly inhibits osteoclast formation,” Annals of the Rheumatic Diseases, vol. 67, no. 11, pp. 1603–1609, 2008. View at Publisher · View at Google Scholar · View at Scopus
  45. M. Cutolo and S. G. Nadler, “Advances in CTLA-4-Ig-mediated modulation of inflammatory cell and immune response activation in rheumatoid arthritis,” Autoimmunity Reviews, vol. 12, no. 7, pp. 758–767, 2013. View at Publisher · View at Google Scholar
  46. B. Bedi, J.-Y. Li, F. Grassi, H. Tawfeek, M. N. Weitzmann, and R. Pacifici, “Inhibition of antigen presentation and T cell costimulation blocks PTH-induced bone loss,” Annals of the New York Academy of Sciences, vol. 1192, pp. 215–221, 2010. View at Publisher · View at Google Scholar · View at Scopus