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Mediators of Inflammation
Volume 2014, Article ID 485743, 10 pages
http://dx.doi.org/10.1155/2014/485743
Research Article

Consequences of the Lack of CD73 and Prostatic Acid Phosphatase in the Lymphoid Organs

1MediCity Research Laboratory, University of Turku, Tykistökatu 6 A, 20520 Turku, Finland
2Department of Medical Microbiology and Immunology, University of Turku, 20014 Turku, Finland
3National Institute for Health and Welfare, 20520 Turku, Finland
4Department of Physiology and Turku Center for Disease Modeling, Institute of Biomedicine, University of Turku, 20014 Turku, Finland
5Department of Medical Biochemistry and Genetics, University of Turku, 20014 Turku, Finland
6Department of Clinical Chemistry, and Helsinki University Hospital Laboratory, University of Helsinki, 00014 Helsinki, Finland

Received 2 May 2014; Revised 27 June 2014; Accepted 7 August 2014; Published 24 August 2014

Academic Editor: Jean Sévigny

Copyright © 2014 Gennady G. Yegutkin et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. W. G. Junger, “Immune cell regulation by autocrine purinergic signalling,” Nature Reviews Immunology, vol. 11, no. 3, pp. 201–212, 2011. View at Publisher · View at Google Scholar · View at Scopus
  2. J. Linden and C. Cekic, “Regulation of lymphocyte function by adenosine,” Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 32, no. 9, pp. 2097–2103, 2012. View at Publisher · View at Google Scholar · View at Scopus
  3. H. K. Eltzschig, M. V. Sitkovsky, and S. C. Robson, “Purinergic signaling during inflammation,” New England Journal of Medicine, vol. 367, no. 24, pp. 2322–2333, 2012. View at Publisher · View at Google Scholar · View at Scopus
  4. M. Salmi and S. Jalkanen, “Ectoenzymes in leukocyte migration and their therapeutic potential,” Seminars in Immunopathology, vol. 36, no. 2, pp. 163–176, 2014. View at Google Scholar
  5. P. Koszalka, B. Özüyaman, Y. Huo et al., “Targeted disruption of cd73/ecto-5′-nucleotidase alters thromboregulation and augments vascular inflammatory response,” Circulation Research, vol. 95, no. 8, pp. 814–821, 2004. View at Publisher · View at Google Scholar · View at Scopus
  6. A. Zernecke, K. Bidzhekov, B. Özüyaman et al., “CD73/Ecto-5′-nucleotidase protects against vascular inflammation and neointima formation,” Circulation, vol. 113, no. 17, pp. 2120–2127, 2006. View at Publisher · View at Google Scholar · View at Scopus
  7. M. Takedachi, D. Qu, Y. Ebisuno et al., “CD73-generated adenosine restricts lymphocyte migration into draining lymph nodes,” The Journal of Immunology, vol. 180, no. 9, pp. 6288–6296, 2008. View at Publisher · View at Google Scholar · View at Scopus
  8. J. Kiss, G. G. Yegutkin, K. Koskinen, T. Savunen, S. Jalkanen, and M. Salmi, “IFN-β protects from vascular leakage via up-regulation of CD73,” European Journal of Immunology, vol. 37, no. 12, pp. 3334–3338, 2007. View at Publisher · View at Google Scholar · View at Scopus
  9. S. Deaglio, K. M. Dwyer, W. Gao et al., “Adenosine generation catalyzed by CD39 and CD73 expressed on regulatory T cells mediates immune suppression,” Journal of Experimental Medicine, vol. 204, no. 6, pp. 1257–1265, 2007. View at Publisher · View at Google Scholar · View at Scopus
  10. M. Mandapathil, S. Lang, E. Gorelik, and T. L. Whiteside, “Isolation of functional human regulatory T cells (Treg) from the peripheral blood based on the CD39 expression,” Journal of Immunological Methods, vol. 346, no. 1-2, pp. 55–63, 2009. View at Publisher · View at Google Scholar · View at Scopus
  11. A. B. Gutman and E. B. Gutman, “An Acid Phosphatase occurring in the serum of patients with metastasizing carcinoma of the prostate gland,” The Journal of Clinical Investigation, vol. 17, no. 4, pp. 473–478, 1938. View at Google Scholar
  12. M. A. Cheever and C. S. Higano, “PROVENGE (sipuleucel-T) in prostate cancer: the first FDA-approved therapeutic cancer vaccine,” Clinical Cancer Research, vol. 17, no. 11, pp. 3520–3526, 2011. View at Publisher · View at Google Scholar · View at Scopus
  13. I. B. Quintero, C. L. Araujo, A. E. Pulkka et al., “Prostatic acid phosphatase is not a prostate specific target,” Cancer Research, vol. 67, no. 14, pp. 6549–6554, 2007. View at Publisher · View at Google Scholar · View at Scopus
  14. A. C. Cunha, B. Weigle, A. Kiessling, M. Bachmann, and E. P. Rieber, “Tissue-specificity of prostate specific antigens: comparative analysis of transcript levels in prostate and non-prostatic tissues,” Cancer Letters, vol. 236, no. 2, pp. 229–238, 2006. View at Publisher · View at Google Scholar · View at Scopus
  15. H. Nousiainen, I. Quintero, T. Myöhänen et al., “Mice deficient in transmembrane prostatic acid phosphatase display increased gabaergic transmission and neurological alterations,” PloS ONE, vol. 9, no. 5, Article ID e97851, 2014. View at Publisher · View at Google Scholar
  16. P. Vihko, “Characterization of the principal human prostatic acid phosphatase isoenzyme, purified by affinity chromatography and isoelectric focusing, part II,” Clinical Chemistry, vol. 24, no. 10, pp. 1783–1787, 1978. View at Google Scholar · View at Scopus
  17. M. J. Zylka, N. A. Sowa, B. Taylor-Blake et al., “Prostatic acid phosphatase is an ectonucleotidase and suppresses pain by generating adenosine,” Neuron, vol. 60, no. 1, pp. 111–122, 2008. View at Publisher · View at Google Scholar · View at Scopus
  18. H. Zimmermann, “Prostatic acid phosphatase, a neglected ectonucleotidase,” Purinergic Signalling, vol. 5, no. 3, pp. 273–275, 2009. View at Publisher · View at Google Scholar · View at Scopus
  19. S. E. Street, P. L. Walsh, N. A. Sowa et al., “PAP and NT5E inhibit nociceptive neurotransmission by rapidly hydrolyzing nucleotides to adenosine,” Molecular Pain, vol. 7, article 80, 2011. View at Publisher · View at Google Scholar · View at Scopus
  20. L. F. Thompson, H. K. Eltzschig, J. C. Ibla et al., “Crucial role for ecto-5′-nucleotidase (CD73) in vascular leakage during hypoxia,” Journal of Experimental Medicine, vol. 200, no. 11, pp. 1395–1405, 2004. View at Publisher · View at Google Scholar · View at Scopus
  21. P. Vihko, I. Quintero, A. Rönkö et al., “Prostatic acid phosphatase (PAP) is pi(3)p-phosphatase and its inactivation leads to change of cell polarity and invasive prostate cancer,” in Proceedings of the AACR Abstract 5239: 96th Annual Meeting, Anaheim, Calif, USA, 2005.
  22. P. Vihko, M. Kontturi, and L. K. Korhonen, “Purification of human prostatic acid phosphatase by affinity chromatography and isoelectric focusing, part I,” Clinical Chemistry, vol. 24, no. 3, pp. 466–470, 1978. View at Google Scholar · View at Scopus
  23. A. M. Herrala, I. B. Quintero, and P. T. Vihko, “Purification of prostatic acid phosphatase (PAP) for structural and functional studies,” Methods in Molecular Biology, vol. 1053, pp. 167–178, 2013. View at Publisher · View at Google Scholar · View at Scopus
  24. G. G. Yegutkin, J. Hytönen, S. S. Samburski, H. Yrjänäinen, S. Jalkanen, and M. K. Viljanen, “Disordered lymphoid purine metabolism contributes to the pathogenesis of persistent Borrelia garinii infection in mice,” Journal of Immunology, vol. 184, no. 9, pp. 5112–5120, 2010. View at Publisher · View at Google Scholar · View at Scopus
  25. N. Mercier, T. O. Kiviniemi, A. Saraste et al., “Impaired ATP-induced coronary blood flow and diminished aortic NTPDase activity precede lesion formation in apolipoprotein E-deficient mice,” The American Journal of Pathology, vol. 180, no. 1, pp. 419–428, 2012. View at Publisher · View at Google Scholar · View at Scopus
  26. D. Langer, K. Hammer, P. Koszalka, J. Schrader, S. Robson, and H. Zimmermann, “Distribution of ectonucleotidases in the rodent brain revisited,” Cell and Tissue Research, vol. 334, no. 2, pp. 199–217, 2008. View at Publisher · View at Google Scholar · View at Scopus
  27. G. G. Yegutkin, F. Marttila-Ichihara, M. Karikoski et al., “Altered purinergic signaling in CD73-deficient mice inhibits tumor progression,” European Journal of Immunology, vol. 41, no. 5, pp. 1231–1241, 2011. View at Publisher · View at Google Scholar · View at Scopus
  28. J. D. Kaunitz and D. T. Yamaguchi, “TNAP, TrAP, ecto-purinergic signaling, and bone remodeling,” Journal of Cellular Biochemistry, vol. 105, no. 3, pp. 655–662, 2008. View at Publisher · View at Google Scholar · View at Scopus
  29. M. I. Bak and J. S. Ingwall, “Regulation of cardiac AMP-specific 5′-nucleotidase during ischemia mediates ATP resynthesis on reflow,” The American Journal of Physiology—Cell Physiology, vol. 274, no. 4, pp. C992–C1001, 1998. View at Google Scholar · View at Scopus
  30. I. B. Quintero, A. M. Herrala, C. L. Araujo et al., “Transmembrane prostatic acid phosphatase (TMPAP) interacts with snapin and deficient mice develop prostate adenocarcinoma,” PLoS ONE, vol. 8, no. 9, Article ID e73072, 2013. View at Google Scholar
  31. C. L. Araujo, I. B. Quintero, and A. Kipar, “Prostatic acid phosphatase is the main acid phosphatase with 5′-ectonucleotidase activity in the male mouse saliva and regulates salivation,” The American Journal of Physiology—Cell Physiology, vol. 306, no. 11, pp. C1017–C1027, 2014. View at Google Scholar
  32. A. Ohta, R. Kini, M. Subramanian et al., “The development and immunosuppressive functions of CD4(+) CD25(+) FoxP3(+) regulatory T cells are under influence of the adenosine-A2a adenosine receptor pathway,” Frontiers in Immunology, vol. 3, p. 190, 2012. View at Google Scholar
  33. H. Ehrentraut, E. T. Clambey, E. N. McNamee et al., “CD73+ regulatory T cells contribute to adenosine-mediated resolution of acute lung injury,” The FASEB Journal, vol. 27, no. 6, pp. 2207–2219, 2013. View at Publisher · View at Google Scholar · View at Scopus
  34. S. Sakaguchi, D. A. A. Vignali, A. Y. Rudensky, R. E. Niec, and H. Waldmann, “The plasticity and stability of regulatory T cells,” Nature Reviews Immunology, vol. 13, no. 6, pp. 461–467, 2013. View at Publisher · View at Google Scholar · View at Scopus
  35. C. H. Kim, “Migration and function of FoxP3+ regulatory T cells in the hematolymphoid system,” Experimental Hematology, vol. 34, no. 8, pp. 1033–1040, 2006. View at Publisher · View at Google Scholar · View at Scopus