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Mediators of Inflammation
Volume 2014, Article ID 590654, 9 pages
http://dx.doi.org/10.1155/2014/590654
Research Article

Regulation of Chemokine CCL5 Synthesis in Human Peritoneal Fibroblasts: A Key Role of IFN-γ

1Department of Nephrology and Medical Intensive Care, Charité-Universitätsmedizin Berlin, Campus Virchow-Klinikum, Augustenburger Platz 1, 13353 Berlin, Germany
2Department of Pathophysiology, Poznan University of Medical Sciences, Swiecickiego 6, 60-781 Poznań, Poland

Received 6 September 2013; Revised 8 December 2013; Accepted 12 December 2013; Published 9 January 2014

Academic Editor: Salahuddin Ahmed

Copyright © 2014 Edyta Kawka et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. P. J. Margetts and D. N. Churchill, “Acquired ultrafiltration dysfunction in peritoneal dialysis patients,” Journal of the American Society of Nephrology, vol. 13, no. 11, pp. 2787–2794, 2002. View at Google Scholar · View at Scopus
  2. G. Baroni, A. Schuinski, T. P. de Moraes et al., “Inflammation and the peritoneal membrane: causes and impact on structure and function during peritoneal dialysis,” Mediators of Inflammation, vol. 2012, Article ID 912595, 4 pages, 2012. View at Publisher · View at Google Scholar
  3. U. Kubicka, W. L. Olszewski, W. Tarnowski, K. Bielecki, A. Ziółkowska, and Z. Wierzbicki, “Normal human immune peritoneal cells: subpopulations and functional characteristics,” Scandinavian Journal of Immunology, vol. 44, no. 2, pp. 157–163, 1996. View at Google Scholar · View at Scopus
  4. T. Cichocki, Z. Hanicki, and W. Sulowicz, “Output of peritoneal cells into peritoneal dialysate. Cytochemical and functional studies,” Nephron, vol. 35, no. 3, pp. 175–182, 1983. View at Google Scholar · View at Scopus
  5. B. Geering, C. Stoeckle, S. Conus, and H. U. Simon, “Living and dying for inflammation: neutrophils, eosinophils, basophils,” Trends in Immunology, vol. 34, no. 8, pp. 398–409, 2013. View at Publisher · View at Google Scholar
  6. O. Devuyst, P. J. Margetts, and N. Topley, “The pathophysiology of the peritoneal membrane,” Journal of the American Society of Nephrology, vol. 21, no. 7, pp. 1077–1085, 2010. View at Publisher · View at Google Scholar · View at Scopus
  7. J. Witowski, A. Thiel, R. Dechend et al., “Synthesis of C-X-C and C-C chemokines by human peritoneal fibroblasts: induction by macrophage-derived cytokines,” American Journal of Pathology, vol. 158, no. 4, pp. 1441–1450, 2001. View at Google Scholar · View at Scopus
  8. G. Parsonage, A. D. Filer, O. Haworth et al., “A stromal address code defined by fibroblasts,” Trends in Immunology, vol. 26, no. 3, pp. 150–156, 2005. View at Publisher · View at Google Scholar · View at Scopus
  9. J. Witowski, H. Tayama, K. Ksiek, M. Wanic-Kossowska, T. O. Bender, and A. Jörres, “Human peritoneal fibroblasts are a potent source of neutrophil-targeting cytokines: a key role of IL-1Β stimulation,” Laboratory Investigation, vol. 89, no. 4, pp. 414–424, 2009. View at Publisher · View at Google Scholar · View at Scopus
  10. V. Appay and S. L. Rowland-Jones, “RANTES: a versatile and controversial chemokine,” Trends in Immunology, vol. 22, no. 2, pp. 83–87, 2001. View at Publisher · View at Google Scholar · View at Scopus
  11. A. M. Krensky and Y.-T. Ahn, “Mechanisms of disease: regulation of RANTES (CCL5) in renal disease,” Nature Clinical Practice Nephrology, vol. 3, no. 3, pp. 164–170, 2007. View at Publisher · View at Google Scholar · View at Scopus
  12. Y. Makino, D. N. Cook, O. Smithies et al., “Impaired T cell function in RANTES-deficient mice,” Clinical Immunology, vol. 102, no. 3, pp. 302–309, 2002. View at Publisher · View at Google Scholar · View at Scopus
  13. A. Jörres, K. Ludat, J. Lang et al., “Establishment and functional characterization of human peritoneal fibroblasts in culture: regulation of interleukin-6 production by proinflammatory cytokines,” Journal of the American Society of Nephrology, vol. 7, no. 10, pp. 2192–2201, 1996. View at Google Scholar · View at Scopus
  14. R. Catar, J. Witowski, P. Wagner et al., “The proto-oncogene c-Fos transcriptionally regulates VEGF production during peritoneal inflammation,” Kidney International, vol. 84, pp. 1119–1128, 2013. View at Publisher · View at Google Scholar
  15. A. Jörres, H. Dinter, N. Topley, G. M. Gahl, U. Frei, and P. Scholz, “Inhibition of tumour necrosis factor production in endotoxin-stimulated human mononuclear leukocytes by the prostacyclin analogue iloprost: cellular mechanisms,” Cytokine, vol. 9, no. 2, pp. 119–125, 1997. View at Publisher · View at Google Scholar · View at Scopus
  16. R. L. Robson, R. M. McLoughlin, J. Witowski et al., “Differential regulation of chemokine production in human peritoneal mesothelial cells: IFN-γ controls neutrophil migration across the mesothelium in vitro and in vivo,” Journal of Immunology, vol. 167, no. 2, pp. 1028–1038, 2001. View at Google Scholar · View at Scopus
  17. N. Abdel-Haq, H.-N. Hao, and W. D. Lyman, “Cytokine regulation of CD40 expression in fetal human astrocyte cultures,” Journal of Neuroimmunology, vol. 101, no. 1, pp. 7–14, 1999. View at Publisher · View at Google Scholar · View at Scopus
  18. A. Glik, J. Mazar, B. Rogachev, M. Zlotnik, and A. Douvdevani, “CD40 ligand expression correlates with resolution of peritonitis and mononuclear cell recruitment,” Peritoneal Dialysis International, vol. 25, no. 3, pp. 240–247, 2005. View at Google Scholar · View at Scopus
  19. H. M. McGettrick, C. D. Buckley, A. Filer, G. Ed Rainger, and G. B. Nash, “Stromal cells differentially regulate neutrophil and lymphocyte recruitment through the endothelium,” Immunology, vol. 131, no. 3, pp. 357–370, 2010. View at Publisher · View at Google Scholar · View at Scopus
  20. C. E. Visser, J. Tekstra, J. J. E. Brouwer-Steenbergen et al., “Chemokines produced by mesothelial cells: huGRO-α, IP-10, MCP-1 and RANTES,” Clinical and Experimental Immunology, vol. 112, no. 2, pp. 270–275, 1998. View at Publisher · View at Google Scholar · View at Scopus
  21. F. K. Li, A. Davenport, R. L. Robson et al., “Leukocyte migration across human peritoneal mesothelial cells is dependent on directed chemokine secretion and ICAM-1 expression,” Kidney International, vol. 54, no. 6, pp. 2170–2183, 1998. View at Publisher · View at Google Scholar · View at Scopus
  22. J. D. Williams, K. J. Craig, C. Von Ruhland, N. Topley, and G. T. Williams, “The natural course of peritoneal membrane biology during peritoneal dialysis,” Kidney International, Supplement, vol. 64, no. 88, pp. S43–S49, 2003. View at Google Scholar · View at Scopus
  23. B. Haslinger-Löffler, B. Wagner, M. Brück et al., “Staphylococcus aureus induces caspase-independent cell death in human peritoneal mesothelial cells,” Kidney International, vol. 70, no. 6, pp. 1089–1098, 2006. View at Publisher · View at Google Scholar · View at Scopus
  24. A. Andoh, H. Takaya, T. Saotome et al., “Cytokine regulation of chemokine (IL-8, MCP-1, and RANTES) gene expression in human pancreatic periacinar myofibroblasts,” Gastroenterology, vol. 119, no. 1, pp. 211–219, 2000. View at Google Scholar · View at Scopus
  25. A. Enzerink, P. Salmenperä, E. Kankuri, and A. Vaheri, “Clustering of fibroblasts induces proinflammatory chemokine secretion promoting leukocyte migration,” Molecular Immunology, vol. 46, no. 8-9, pp. 1787–1795, 2009. View at Publisher · View at Google Scholar · View at Scopus
  26. D. Eyman, M. Damodarasamy, S. R. Plymate, and M. J. Reed, “CCL5 secreted by senescent aged fibroblasts induces proliferation of prostate epithelial cells and expression of genes that modulate angiogenesis,” Journal of Cellular Physiology, vol. 220, no. 2, pp. 376–381, 2009. View at Publisher · View at Google Scholar · View at Scopus
  27. M. Mustafa, B. Wondimu, M. Bakhiet, and T. Modéer, “Production of Rantes/CCL5 in human gingival fibroblasts challenged with tumor necrosis factor α,” European Journal of Oral Sciences, vol. 109, no. 1, pp. 44–49, 2001. View at Google Scholar · View at Scopus
  28. F. Saji, M. Nonaka, and R. Pawankar, “Expression of RANTES by IL-1 β and TNF-α stimulated nasal polyp fibroblasts,” Auris Nasus Larynx, vol. 27, no. 3, pp. 247–252, 2000. View at Publisher · View at Google Scholar · View at Scopus
  29. J. E. Meyer, I. Berner, L. M. Teran et al., “RANTES production by cytokine-stimulated nasal fibroblasts: its inhibition by glucocorticoids,” International Archives of Allergy and Immunology, vol. 117, no. 1, pp. 60–67, 1998. View at Publisher · View at Google Scholar · View at Scopus
  30. M.-L. Cho, S.-Y. Min, S.-H. Chang et al., “Transforming growth factor beta 1(TGF-β1) down-regulates TNFα-induced RANTES production in rheumatoid synovial fibroblasts through NF-κB-mediated transcriptional repression,” Immunology Letters, vol. 105, no. 2, pp. 159–166, 2006. View at Publisher · View at Google Scholar · View at Scopus
  31. K. M. Fries, T. Blieden, R. J. Looney et al., “Evidence of fibroblast heterogeneity and the role of fibroblast subpopulations in fibrosis,” Clinical Immunology and Immunopathology, vol. 72, no. 3, pp. 283–292, 1994. View at Publisher · View at Google Scholar · View at Scopus
  32. G. Parsonage, F. Falciani, A. Burman et al., “Global gene expression profiles in fibroblasts from synovial, skin and lymphoid tissue levels distinct cytokine and chemokine expression patterns,” Thrombosis and Haemostasis, vol. 90, no. 4, pp. 688–697, 2003. View at Google Scholar · View at Scopus
  33. M. K. Dasgupta, M. Larabie, and P. F. Halloran, “Interferon-gamma levels in peritoneal dialysis effluents: relation to peritonitis,” Kidney International, vol. 46, no. 2, pp. 475–481, 1994. View at Google Scholar · View at Scopus
  34. P. Rathanaswami, M. Hachicha, M. Sadick, T. J. Schall, and S. R. McColl, “Expression of the cytokine RANTES in human rheumatoid synovial fibroblasts. Differential regulation of RANTES and interleukin-8 genes by inflammatory cytokines,” The Journal of Biological Chemistry, vol. 268, no. 8, pp. 5834–5839, 1993. View at Google Scholar · View at Scopus
  35. A. Marfaing-Koka, O. Devergne, G. Gorgone et al., “Regulation of the production of the RANTES chemokine by endothelial cells: synergistic induction by IFN-γ plus TNF-α and inhibition by IL-4 and IL-13,” Journal of Immunology, vol. 154, no. 4, pp. 1870–1878, 1995. View at Google Scholar · View at Scopus
  36. A. Casola, A. Henderson, T. Liu, R. P. Garofalo, and A. R. Brasier, “Regulation of RANTES promoter activation in alveolar epithelial cells after cytokine stimulation,” American Journal of Physiology, vol. 283, no. 6, pp. L1280–L1290, 2002. View at Google Scholar · View at Scopus
  37. J. Liu, X. Guan, and X. Ma, “Interferon regulatory factor 1 is an essential and direct transcriptional activator for interferon γ-induced RANTES/CC15 expression in macrophages,” The Journal of Biological Chemistry, vol. 280, no. 26, pp. 24347–24355, 2005. View at Publisher · View at Google Scholar · View at Scopus
  38. Y. Ohmori, R. D. Schreiber, and T. A. Hamilton, “Synergy between interferon-γ and tumor necrosis factor-α in transcriptional activation is mediated by cooperation between signal transducer and activator of transcription 1 and nuclear factor κB,” The Journal of Biological Chemistry, vol. 272, no. 23, pp. 14899–14907, 1997. View at Publisher · View at Google Scholar · View at Scopus
  39. A. H. Lee, J.-H. Hong, and Y.-S. Seo, “Tumor necrosis factor-α and interferon-γ synergistically activated the RANTES promoter through nuclear factor κB and interferon regulatory factor 1 (IRF-1) transcription factors,” Biochemical Journal, vol. 350, no. 1, pp. 131–138, 2000. View at Publisher · View at Google Scholar · View at Scopus
  40. P. Génin, M. Algarté, P. Roof, R. Lin, and J. Hiscott, “Regulation of RANTES chemokine gene expression requires cooperativity between NF-κB, and IFN-regulatory factor transcription factors,” Journal of Immunology, vol. 164, no. 10, pp. 5352–5361, 2000. View at Google Scholar · View at Scopus
  41. M. Pérez Fontán, A. Rodríguez-Carmona, I. Galed, P. Iglesias, P. Villaverde, and E. García-Ureta, “Incidence and significance of peritoneal eosinophilia during peritoneal dialysis-related peritonitis,” Peritoneal Dialysis International, vol. 23, no. 5, pp. 460–464, 2003. View at Google Scholar · View at Scopus
  42. C. Quinlan, M. Cantwell, and L. Rees, “Eosinophilic peritonitis in children on chronic peritoneal dialysis,” Pediatric Nephrology, vol. 25, no. 3, pp. 517–522, 2010. View at Publisher · View at Google Scholar · View at Scopus
  43. K. Wieczorowska-Tobis, R. Brelinska, J. Witowski et al., “Evidence for less irritation to the peritoneal membrane in rats dialyzed with solutions low in glucose degradation products,” Peritoneal Dialysis International, vol. 24, no. 1, pp. 48–57, 2004. View at Google Scholar · View at Scopus
  44. K. M. Fries, G. D. Sempowski, A. A. Gaspari, T. Blieden, R. J. Looney, and R. P. Phipps, “CD40 expression by human fibroblasts,” Clinical Immunology and Immunopathology, vol. 77, no. 1, pp. 42–51, 1995. View at Google Scholar · View at Scopus
  45. A. Basok, A. Shnaider, L. Man, C. Chaimovitz, and A. Douvdevani, “CD40 is expressed on human peritoneal mesothelial cells and upregulates the production of interleukin-15 and RANTES,” Journal of the American Society of Nephrology, vol. 12, no. 4, pp. 695–702, 2001. View at Google Scholar · View at Scopus
  46. C. M. Gelbmann, S. N. Leeb, D. Vogl et al., “Inducible CD40 expression mediates NFκB activation and cytokine secretion in human colonic fibroblasts,” Gut, vol. 52, no. 10, pp. 1448–1456, 2003. View at Publisher · View at Google Scholar · View at Scopus
  47. L. De, T. Karlson, C. V. Whiting, and P. W. Bland, “Proinflammatory cytokine synthesis by mucosal fibroblasts from mouse colitis is enhanced by interferon-γ-mediated up-regulation of CD40 signalling,” Clinical and Experimental Immunology, vol. 148, no. 1, p. 188, 2007. View at Publisher · View at Google Scholar · View at Scopus