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Mediators of Inflammation
Volume 2014, Article ID 979132, 8 pages
http://dx.doi.org/10.1155/2014/979132
Research Article

Effects of Antisense Oligonucleotides against C-Reactive Protein on the Development of Atherosclerosis in WHHL Rabbits

1Department of Molecular Pathology, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, Yamanashi, Chuo-City 409-3898, Japan
2Department of Histology and Embryology, Xi'an Medical University, Xi'an 710021, China
3Department of Pathology, Shengjing Hospital of China Medical University, Shenyang 110003, China
4Experimental Animal Center and Animal Models for Cardiovascular Diseases, Kobe University School of Medicine, Kobe 6500017, Japan
5Isis Pharmaceuticals Inc., Carlsbad, CA 92008, USA
6Research Institute of Atherosclerotic Disease and Laboratory Animal Center, Xi'an Jiaotong University School of Medicine, Xi'an 710061, China
7Key Lab of Urban Environment and Health, Institute of Urban Environment, Chinese Academy of Sciences, Xiamen 361021, China

Received 2 March 2014; Accepted 1 April 2014; Published 27 April 2014

Academic Editor: Alexander Szalai

Copyright © 2014 Qi Yu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Increased plasma levels of C-reactive protein (CRP) are closely associated with cardiovascular diseases, but whether CRP is directly involved in the pathogenesis of atherosclerosis is still under debate. Many controversial and contradictory results using transgenic mice and rabbits have been published but it is also unclear whether CRP lowering can be used for the treatment of atherosclerosis. In the current study, we examined the effects of the rabbit CRP antisense oligonucleotides (ASO) on the development of atherosclerosis in WHHL rabbits. CRP ASO treatment led to a significant reduction of plasma CRP levels; however, both aortic and coronary atherosclerotic lesions were not significantly changed compared to those of control WHHL rabbits. These results suggest that inhibition of plasma CRP does not affect the development of atherosclerosis in WHHL rabbits.