Table of Contents Author Guidelines Submit a Manuscript
Retracted

Mediators of Inflammation has retracted this article. After a concern was raised to them by a reader, the authors contacted the journal to replace the anti-ACC blot in Figure (b), providing the original figure. The journal found that the published blot in Figure (b) was similar in other articles [29]. Due to this, the journal reassessed the other figures and found that, for the β-actin bands in Figure (c), lanes 3 and 4 are similar to lanes 5 and 6, respectively. Although the authors provided the journal with the underlying blots for all the figures, the journal and authors decided to retract the manuscript. The replacement blot for Figure (b) and the underlying blots for all figures are available in the Supplementary Materials. The authors stated that the representative loading control bands in Figures (c) and (b) were improperly assembled, leading to repetitions of bands, and that these errors do not affect the results, once several papers have demonstrated that exercise does not change both, ACC [10, 11] and actin [1214] protein content, in the skeletal muscle of rodents. In light of the figure preparation issues, the authors sincerely apologize to the scientific community for any misunderstanding that these errors may have caused.

View the full Retraction here.

References

  1. N. R. Oliveira, S. O. Marques, T. F. Luciano et al., “Treadmill training increases SIRT-1 and PGC-1α protein levels and AMPK phosphorylation in quadriceps of middle-aged rats in an intensity-dependent manner,” Mediators of Inflammation, vol. 2014, Article ID 987017, 11 pages, 2014.
  2. L. S. S. Pauli, E. C. C. Ropelle, C. T. de Souza et al., “Exercise training decreases mitogen-activated protein kinase phosphatase-3 expression and suppresses hepatic gluconeogenesis in obese mice,” Journal of Physiology, vol. 592, no. 6, pp. 1325–1340, 2014.
  3. E. C. Chiarreotto-Ropelle, L. S. S. Pauli, C. K. Katashima et al., “Acute exercise suppresses hypothalamic PTP1B protein level and improves insulin and leptin signaling in obese rats,” American Journal of Physiology - Endocrinology and Metabolism, vol. 305, no. 5, pp. E649–E659, 2013.
  4. E. R. Ropelle, M. B. Flores, D. E. Cintra, G. Z. Rocha, Pauli. J. r et al., “IL-6 and IL-10 Anti-Inflammatory Activity Links Exercise to Hypothalamic Insulin and Leptin Sensitivity through IKKβ and ER Stress Inhibition,” PLOS Biology, vol. 8, no. 8, Article ID e1000465, 2010.
  5. Flores, B. S. Marcelo et al., “Obesity-Induced Increase in Tumor Necrosis Factor-α Leads to Development of Colon Cancer in Mice,” Gastroenterology, vol. 143, no. 3, pp. 741–753.e4, 2012, http://dx.doi.org/10.1053/j.gastro.2012.05.045.
  6. P. O. Prada, P. G. F. Quaresma, A. M. Caricilli et al., “Tub has a key role in insulin and leptin signaling and action in vivo in hypothalamic nuclei,” Diabetes, vol. 62, no. 1, pp. 137–148, 2013.
  7. V. A. Barbosa, T. F. Luciano, S. O. Marques et al., “Acute exercise induce endothelial nitric oxide synthase phosphorylation via Akt and AMP-activated protein kinase in aorta of rats: Role of reactive oxygen species,” International Journal of Cardiology, vol. 167, no. 6, pp. 2983–2988, 2013.
  8. Statement of Retraction, “Tub Has a Key Role in Insulin and Leptin Signaling and Action In Vivo in Hypothalamic Nuclei,” Diabetes, vol. 62, pp. 137–148, 2013.
  9. J. Expression of concern. Physiol, “Expression of concern,” The Journal of Physiology, vol. 594, pp. 5027-5028, 2016.
  10. H. M. O’Neill, J. S. Lally, S. Galic et al., “Skeletal muscle ACC2 S212 phosphorylation is not required for the control of fatty acid oxidation during exercise,” Physiological Reports, vol. 3, no. 7, Article ID e12444, 2015.
  11. R. A. Gulli, J. M. Tishinsky, T. MacDonald, L. E. Robinson, D. C. Wright, and D. J. Dyck, “Exercise restores insulin, but not adiponectin, response in skeletal muscle of high-fat fed rodents,” American Journal of Physiology - Regulatory Integrative and Comparative Physiology, vol. 303, no. 10, pp. R1062–R1070, 2012.
  12. C. He, M. C. Bassik, V. Moresi et al., “Exercise-induced BCL2-regulated autophagy is required for muscle glucose homeostasis,” Nature, vol. 481, no. 7382, pp. 511–515, 2012.
  13. J. H. Woo, K. O. Shin, Y. H. Lee, K. S. Jang, J. Y. Bae, and H. T. Roh, “Effects of treadmill exercise on skeletal muscle mTOR signaling pathway in high-fat diet-induced obese mice,” Journal of Physical Therapy Science, vol. 28, no. 4, pp. 1260–1265, 2016.
  14. G. Li, J. Wang, J. Ye, Y. Zhang, and Y. Zhang, “PPARα protein expression was increased by four weeks of intermittent hypoxic training via AMPKα2-dependent manner in mouse skeletal muscle,” PLoS ONE, vol. 10, no. 4, Article ID e0122593, 2015.
Mediators of Inflammation
Volume 2014, Article ID 987017, 11 pages
http://dx.doi.org/10.1155/2014/987017
Research Article

Treadmill Training Increases SIRT-1 and PGC-1α Protein Levels and AMPK Phosphorylation in Quadriceps of Middle-Aged Rats in an Intensity-Dependent Manner

1Laboratory of Exercise Biochemistry and Physiology, Health Sciences Unit, Extremo Sul Catarinense University (UNESC), 88806-000 Criciuma, SC, Brazil
2Faculty of Applied Sciences, University of Campinas (UNICAMP), 13083-872 Limeira, SP, Brazil
3Post Graduation Program in Motricity Science, Instituto de Biociências, São Paulo State University (UNESP), 13506-900 Rio Claro, SP, Brazil
4Human Movement Laboratory, São Judas Tadeu University, 03166-000 São Paulo, SP, Brazil
5Immunometabolism Research Group, Department of Physical Education, São Paulo State University (UNESP), 19060-900 Presidente Prudente, SP, Brazil
6School of Physical Education and Sport of Ribeirão Preto, São Paulo University (USP), 14040-907 Ribeirão Preto, SP, Brazil

Received 19 February 2014; Revised 8 April 2014; Accepted 15 April 2014; Published 9 June 2014

Academic Editor: José Cesar Rosa

Copyright © 2014 Nara R. C. Oliveira et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Citations to this Article [19 citations]

The following is the list of published articles that have cited the current article.

  • Jung Su Ryun, 김상현, Kijin Kim, and Ahn Na-Young, “The Effects of Latter Climbing Exercise Training on PGC-1α Expression and Mitochondrial Biogenesis of Skeletal Muscle in Young and Middle-Aged Rats,” Exercise Science, vol. 23, no. 4, pp. 339–345, 2014. View at Publisher · View at Google Scholar
  • Suryun Jung, and Kijin Kim, “Exercise-induced PGC-1α transcriptional factors in skeletal muscle,” Integrative Medicine Research, 2014. View at Publisher · View at Google Scholar
  • Levente Szalárdy, Dénes Zádori, Péter Klivényi, József Toldi, and László Vécsei, “Electron Transport Disturbances and Neurodegeneration: From Albert Szent-Györgyi’s Concept (Szeged) till Novel Approaches to Boost Mitochondrial Bioenergetics,” Oxidative Medicine and Cellular Longevity, vol. 2015, pp. 1–19, 2015. View at Publisher · View at Google Scholar
  • Lasse Gliemann, “Training for skeletal muscle capillarization: a Janus-faced role of exercise intensity?,” European Journal of Applied Physiology, 2016. View at Publisher · View at Google Scholar
  • Ryan G. Toedebusch, Gregory N. Ruegsegger, Joshua F. Braselton, Alexander J. Heese, John C. Hofheins, Tom E. Childs, John P. Thyfault, and Frank W. Booth, “AMPK agonist AICAR delays the initial decline in lifetime-apex (V) over dotO(2) (peak), while voluntary wheel running fails to delay its initial decli,” Physiological Genomics, vol. 48, no. 2, pp. 101–115, 2016. View at Publisher · View at Google Scholar
  • J. L. Brown, M. E. Rosa-Caldwell, D. E. Lee, L. A. Brown, R. A. Perry, K. L. Shimkus, T. A. Blackwell, J. D. Fluckey, J. A. Carson, S. Dridi, T. A. Washington, and N. P. Greene, “ PGC-1 α 4 gene expression is suppressed by the IL-6-MEK-ERK 1/2 MAPK signalling axis and altered by resistance exercise, obesity and muscle injury ,” Acta Physiologica, 2016. View at Publisher · View at Google Scholar
  • Sintip Pattanakuhar, Anchalee Pongchaidecha, Nipon Chattipakorn, and Siriporn C. Chattipakorn, “The effect of exercise on skeletal muscle fibre type distribution in obesity: From cellular levels to clinical application,” Obesity Research & Clinical Practice, 2016. View at Publisher · View at Google Scholar
  • Jung-Hoon Koo, and Joon-Yong Cho, “Treadmill Exercise Attenuates ?-Synuclein Levels by Promoting Mitochondrial Function and Autophagy Possibly via SIRT1 in the Chronic MPTP/P-Induced Mouse Model of Parkinson?s Disease,” Neurotoxicity Research, 2017. View at Publisher · View at Google Scholar
  • Rodrigo Pereira, José Botezelli, Kellen da Cruz Rodrigues, Rania Mekary, Dennys Cintra, José Pauli, Adelino da Silva, Eduardo Ropelle, and Leandro de Moura, “Fructose Consumption in the Development of Obesity and the Effects of Different Protocols of Physical Exercise on the Hepatic Metabolism,” Nutrients, vol. 9, no. 4, pp. 405, 2017. View at Publisher · View at Google Scholar
  • Young-Min Park, Jaume Padilla, Rebecca J. Welly, Steven L. Britton, Lauren G. Koch, John P. Thyfault, Victoria J. Vieira-Potter, Jill A. Kanaley, Terese M. Zidon, and Frank W. Booth, “Voluntary Running Attenuates Metabolic Dysfunction in Ovariectomized Low-Fit Rats,” Medicine and Science in Sports and Exercise, vol. 49, no. 2, pp. 254–264, 2017. View at Publisher · View at Google Scholar
  • Michele Guescini, Luca Tiano, Maria Luisa Genova, Emanuela Polidori, Sonia Silvestri, Patrik Orlando, Carmela Fimognari, Cinzia Calcabrini, Vilberto Stocchi, and Piero Sestili, “The Combination of Physical Exercise with Muscle-Directed Antioxidants to Counteract Sarcopenia: A Biomedical Rationale for Pleiotropic Treatment with Creatine and Coenzyme Q10,” Oxidative Medicine and Cellular Longevity, vol. 2017, pp. 1–19, 2017. View at Publisher · View at Google Scholar
  • Yan-mei Zhang, Wei Wu, Wei Ma, Fang Wang, and Jun Yuan, “Effect of glycosides of Cistanche on the expression of mitochondrial precursor protein and keratin type II cytoskeletal 6A in a rat model of vascular dementia,” Neural Regeneration Research, vol. 12, no. 7, pp. 1152, 2017. View at Publisher · View at Google Scholar
  • Chihiro Taka, Kazuyuki Tobe, Ryuji Hayashi, Kazuki Shimokawa, Kotaro Tokui, Seisuke Okazawa, Kenta Kambara, Minehiko Inomata, Toru Yamada, and Shoko Matsui, “SIRT1 and FOXO1 mRNA expression in PBMC correlates to physical activity in COPD patients.,” International journal of chronic obstructive pulmonary disease, vol. 12, pp. 3237–3244, 2017. View at Publisher · View at Google Scholar
  • Ju Yong Bae, Jinhee Woo, Sunghwun Kang, and Ki Ok Shin, “Effects of detraining and retraining on muscle energy-sensing network and meteorin-like levels in obese mice,” Lipids in Health and Disease, vol. 17, no. 1, 2018. View at Publisher · View at Google Scholar
  • Shahram Shahraki Zahedani, and Nasrin sayadzai, “Frequency and Antibiotic Resistance Pattern of Diarrheagenic Escherichia coli (DEC) Strains Isolated from Children Aged Less Than 10 Years,” Medical Laboratory Journal, vol. 12, no. 2, pp. 7–12, 2018. View at Publisher · View at Google Scholar
  • Banu Kabak, Muaz Belviranli, and Nilsel Okudan, “Irisin and myostatin responses to acute high-intensity interval exercise in humans,” Hormone Molecular Biology and Clinical Investigation, vol. 35, no. 3, 2018. View at Publisher · View at Google Scholar
  • Ramin Amirsasan, Rahele Dolgari, and Javad Vakili, “Effects of Pilates Training and Turmeric Supplementation on Sirtuin 1 Level and Body Composition in Postmenopausal Females with Sedentary Overweight: A Randomized, Double-Blind, Clinical Trial,” Zahedan Journal of Research in Medical Sciences, vol. 21, no. 3, 2019. View at Publisher · View at Google Scholar
  • Zeinab Rezaee, Sayed Mohammad Marandi, Hojjatallah Alaei, Fahimeh Esfarjani, and Sadegh Feyzollahzadeh, “Effects of Preventive Treadmill Exercise on the Recovery of Metabolic and Mitochondrial Factors in the 6-Hydroxydopamine Rat Model of Parkinson’s Disease,” Neurotoxicity Research, 2019. View at Publisher · View at Google Scholar
  • Xinyi Li, Muhammad Jamal, Peipei Guo, Zhao Jin, Feng Zheng, Xuemin Song, Jia Zhan, and Huisheng Wu, “Irisin alleviates pulmonary epithelial barrier dysfunction in sepsis-induced acute lung injury via activation of AMPK/SIRT1 pathways,” Biomedicine & Pharmacotherapy, vol. 118, pp. 109363, 2019. View at Publisher · View at Google Scholar