Necroptotic Cell Death Signaling and Execution Pathway: Lessons from Knockout Mice

Figure 1

Distinct morphological features of apoptosis and necroptosis. (a) Apoptosis is characterized by cell shrinkage, membrane blebbing condensation, margination of nuclear chromatin, and packaging of apoptotic bodies and its engulfment by neighbor cells. (b) Necroptosis is characterized by the increase in cell volume, swelling of organelles, perforation of plasma membrane, cellular collapse, and release of cellular contents.