Mediators of Inflammation / 2015 / Article / Tab 2

Review Article

Pathogenesis of Myeloproliferative Neoplasms: Role and Mechanisms of Chronic Inflammation

Table 2

Infectious pathogens and toxic compounds known to be associated with chronic inflammation and solid and blood cancers.

Exposure to infectious pathogensAffected cellsAssociated solid cancerAssociated hematological malignancy

Human T-cell leukemia virus 1 (HTLV-1)T-lymphocytesT-cell leukemia
T-cell lymphoma
Hepatitis C virus
(Flavivirus)
Hepatocytes
B-lymphocytes
HepatocarcinomaB-cell lymphoma, plasma cell leukemia, MGUS, and myeloma
Hepatitis B virus (Hepadnavirus)HepatocytesHepatocarcinoma
Epstein-Barr virus
(human herpes virus 4)
B-lymphocytesNasopharynxB-cell lymphoma
MGUS, and myeloma
Human herpes virus 8
(herpes virus)
Fibroblasts
B-lymphocytes
SarcomaB-cell lymphoma, myeloma, and plasma cell leukemia
Human herpes virus 2
(herpes virus)
Epithelial cellsGenital cancer
Human papilloma (papilloma virus)Epithelial cellsGenital cancer
Helicobacter pylori (bacterium)Epithelial cellsGastric carcinomaMALT lymphoma, MGUS, and myeloma
Borrelia burgdorferi (bacterium)Keratinocytes, fibroblasts, dendritic cells, T-lymphocytes, and monocytes/macrophagesSkin lymphoma
Campylobacter jejuni (bacterium)Intestinal cellsImmunoproliferative small intestine disease (IPSID)
Chlamydia psittaci (bacterium)Nasal and pulmonary cellsOcular adnexal lymphoma
Toxoplasma gondii (protozoon)MacrophagesIntraocular B-cell lymphoma
Schistosoma haematobium (Platyhelminthe, Trematoda)Bladder carcinoma
Opisthorchis viverrini (Platyhelminthe, Trematoda)Bile duct carcinoma
Porphyromonas gingivalis
(bacterium)
Gingival/mouth
cancer, pancreatic cancer?

Exposure to toxicsAffected cellsAssociated
solid cancer
Associated hematological disorder or malignancy

TobaccoEpithelial cellsLung cancer
Bladder cancer
Others
Chronic stimulation of myelopoiesis
Asbestos fibers (results in asbestosis, an inflammatory condition)Mesothelial cellsMesothelioma
PesticidesAllLymphoma
BenzeneAllBladder cancerChronic myelogenous leukemia and other myeloid and lymphoid malignancies

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