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Mediators of Inflammation
Volume 2015, Article ID 147056, 8 pages
http://dx.doi.org/10.1155/2015/147056
Research Article

The Influence of Interleukin 17A and IL17F Polymorphisms on Chronic Periodontitis Disease in Brazilian Patients

1Post Graduation Program of Biosciences and Physiopathology, Biomedicine and Clinical Analysis Department, Maringá State University, 87020-900 Maringá, PR, Brazil
2Biomedicine and Clinical Analysis Department, Maringá State University, 87020-900 Maringá, PR, Brazil
3Basic Health Sciences Department, Maringá State University, 87020-900 Maringá, PR, Brazil
4Dentistry Department, Maringá State University, 87020-900 Maringá, PR, Brazil

Received 13 March 2015; Accepted 18 May 2015

Academic Editor: Paula Barrionuevo

Copyright © 2015 Joana Maira Valentini Zacarias et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

A case-control study was conducted on patients with chronic periodontitis (CP) and healthy controls with the aim of evaluating possible association between interleukin 17A (IL17A) G197A (rs2275913) and IL17F T7488C (rs763780) polymorphisms and periodontitis. Genotypes were determined by PCR-RFLP method. Statistical analyses were conducted using the OpenEpi and SNPStas software to calculate Chi-square with Yates correction or Fisher’s exact tests, odds ratios (OR), and 95% confidence intervals (CIs). SNPStas software was used to calculate Hardy-Weinberg equilibrium. IL17A AA genotype was more frequent in patients with chronic periodontitis (CP) in the codominant and recessive models (; OR = 2.53 and ; OR = 2.46, resp.), the females with CP (, OR = 4.34), Caucasoid patients with CP (, OR = 3.45), and nonsmoking Caucasian patients with CP (, OR = 3.51). The IL17A A allele was also more frequent in Caucasians with CP (, OR = 1.59). IL17F T7488C polymorphism was not associated with chronic periodontitis. In these patients from Southern Brazil, the IL17A rs2275913 polymorphisms, IL17A AA genotype, and the A allele were associated with a susceptibility to chronic periodontitis.