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Mediators of Inflammation
Volume 2015 (2015), Article ID 362768, 8 pages
http://dx.doi.org/10.1155/2015/362768
Review Article

Proinflammatory Cytokines and Potassium Channels in the Kidney

Department of Physiology, Iwate Medical University School of Medicine, 2-1-1 Nishitokuta, Yahaba, Iwate 028-3694, Japan

Received 24 July 2015; Accepted 9 September 2015

Academic Editor: Mauricio Retamal

Copyright © 2015 Kazuyoshi Nakamura et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. S. C. Hebert, G. Desir, G. Giebisch, and W. Wang, “Molecular diversity and regulation of renal potassium channels,” Physiological Reviews, vol. 85, no. 1, pp. 319–371, 2005. View at Publisher · View at Google Scholar · View at Scopus
  2. G. H. Giebisch, “A long affair with renal tubules,” Annual Review of Physiology, vol. 73, pp. 1–28, 2011. View at Publisher · View at Google Scholar · View at Scopus
  3. W. B. Reeves and S. V. Shah, “Activation of potassium channels contributes to hypoxic injury in proximal tubules,” The Journal of Clinical Investigation, vol. 94, no. 6, pp. 2289–2294, 1994. View at Publisher · View at Google Scholar · View at Scopus
  4. R. Engbersen, M. M. Moons, A. C. Wouterse et al., “Sulphonylurea drugs reduce hypoxic damage in the isolated perfused rat kidney,” British Journal of Pharmacology, vol. 130, no. 7, pp. 1678–1684, 2000. View at Publisher · View at Google Scholar · View at Scopus
  5. K. Pompermayer, D. G. Souza, G. G. Lara et al., “The ATP-sensitive potassium channel blocker glibenclamide prevents renal ischemia/reperfusion injury in rats,” Kidney International, vol. 67, no. 5, pp. 1785–1796, 2005. View at Publisher · View at Google Scholar · View at Scopus
  6. M. Rahgozar, D. A. Willgoss, G. C. Gobé, and Z. H. Endre, “ATP-dependent K+ channels in renal ischemia reperfusion injury,” Renal Failure, vol. 25, no. 6, pp. 885–896, 2003. View at Publisher · View at Google Scholar · View at Scopus
  7. A. R. Assad, J. M. A. Delou, L. M. Fonseca et al., “The role of KATP channels on propofol preconditioning in a cellular model of renal ischemia-reperfusion,” Anesthesia & Analgesia, vol. 109, no. 5, pp. 1486–1492, 2009. View at Publisher · View at Google Scholar · View at Scopus
  8. R. A. Zager, A. C. Johnson, S. Lund, S. Y. Hanson, and C. K. Abrass, “Levosimendan protects against experimental endotoxemic acute renal failure,” The American Journal of Physiology—Renal Physiology, vol. 290, no. 6, pp. F1453–F1462, 2006. View at Publisher · View at Google Scholar · View at Scopus
  9. C. A. Feghali and T. M. Wright, “Cytokines in acute and chronic inflammation,” Frontiers in Bioscience, vol. 2, pp. 12–26, 1997. View at Google Scholar · View at Scopus
  10. C. A. Dinarello, “Historical insights into cytokines,” European Journal of Immunology, vol. 37, supplement 1, pp. S34–S45, 2007. View at Publisher · View at Google Scholar · View at Scopus
  11. M. Schäfers and L. Sorkin, “Effect of cytokines on neuronal excitability,” Neuroscience Letters, vol. 437, no. 3, pp. 188–193, 2008. View at Publisher · View at Google Scholar · View at Scopus
  12. S. M. Allan, P. J. Tyrrell, and N. J. Rothwell, “Interleukin-1 and neuronal injury,” Nature Reviews Immunology, vol. 5, no. 8, pp. 629–640, 2005. View at Publisher · View at Google Scholar · View at Scopus
  13. V. C. Mehra, V. S. Ramgolam, and J. R. Bender, “Cytokines and cardiovascular disease,” Journal of Leukocyte Biology, vol. 78, no. 4, pp. 805–818, 2005. View at Publisher · View at Google Scholar · View at Scopus
  14. H. Kimura, M. Yoshizumi, H. Ishii, K. Oishi, and A. Ryo, “Cytokine production and signaling pathways in respiratory virus infection,” Frontiers in Microbiology, vol. 4, article 276, 2013. View at Publisher · View at Google Scholar · View at Scopus
  15. H. Akiho, E. Ihara, Y. Motomura, and K. Nakamura, “Cytokine-induced alterations of gastrointestinal motility in gastrointestinal disorders,” World Journal of Gastrointestinal Pathophysiology, vol. 2, no. 5, pp. 72–81, 2011. View at Publisher · View at Google Scholar
  16. E. D. Morrell, J. A. Kellum, K. R. Hallows, and N. M. Pastor-Soler, “Epithelial transport during septic acute kidney injury,” Nephrology Dialysis Transplantation, vol. 29, no. 7, pp. 1312–1319, 2014. View at Publisher · View at Google Scholar · View at Scopus
  17. R. A. Zager, A. C. M. Johnson, and A. Geballe, “Gentamicin suppresses endotoxin-driven TNF-α production in human and mouse proximal tubule cells,” American Journal of Physiology—Renal Physiology, vol. 293, no. 4, pp. F1373–F1380, 2007. View at Publisher · View at Google Scholar · View at Scopus
  18. G. K. Rangan, Y. Wang, Y.-C. Tay, and D. C. H. Harris, “Differential effects of albumin on cytokine gene expression in proximal tubular epithelial cells,” Nephrology Dialysis Transplantation, vol. 20, no. 5, pp. 1013–1014, 2005. View at Publisher · View at Google Scholar · View at Scopus
  19. M. R. Daha and C. van Kooten, “Is the proximal tubular cell a proinflammatory cell?” Nephrology Dialysis Transplantation, vol. 15, supplement 6, pp. 41–43, 2000. View at Google Scholar · View at Scopus
  20. N. Nakhoul and V. Batuman, “Role of proximal tubules in the pathogenesis of kidney disease,” Contributions to Nephrology, vol. 169, pp. 37–50, 2011. View at Publisher · View at Google Scholar · View at Scopus
  21. B. A. Escalante, N. R. Ferreri, C. E. Dunn, and J. C. McGiff, “Cytokines affect ion transport in primary cultured thick ascending limb of Henle's loop cells,” American Journal of Physiology, vol. 266, no. 6, pp. C1568–C1576, 1994. View at Google Scholar · View at Scopus
  22. N. R. Ferreri, B. A. Escalante, Y. Zhao, S.-J. An, and J. C. McGiff, “Angiotensin II induces TNF production by the thick ascending limb: functional implications,” American Journal of Physiology—Renal Physiology, vol. 274, no. 1, pp. F148–F155, 1998. View at Google Scholar · View at Scopus
  23. I. Tikkanen, N. Uhlenius, T. Tikkanen et al., “Increased renal expression of cytokines and growth factors induced by DOCA-NaCl treatment in Heymann nephritis,” Nephrology Dialysis Transplantation, vol. 10, no. 12, pp. 2192–2198, 1995. View at Google Scholar · View at Scopus
  24. J. S. Gerritsma, A. F. Gerritsen, M. De Ley, L. A. van Es, and M. R. Daha, “Interferon-γ induces biosynthesis of complement components C2, C4 and factor H by human proximal tubular epithelial cells,” Cytokine, vol. 9, no. 4, pp. 276–283, 1997. View at Publisher · View at Google Scholar · View at Scopus
  25. J. R. Timoshanko, A. R. Kitching, Y. Iwakura, S. R. Holdsworth, and P. G. Tipping, “Leukocyte-derived interleukin-1β interacts with renal interleukin-1 receptor I to promote renal tumor necrosis factor and glomerular injury in murine crescentic glomerulonephritis,” The American Journal of Pathology, vol. 164, no. 6, pp. 1967–1977, 2004. View at Publisher · View at Google Scholar · View at Scopus
  26. A. Castillo, M. T. Islam, M. C. Prieto, and D. S. A. Majid, “Tumor necrosis factor-α receptor type 1, not type 2, mediates its acute responses in the kidney,” American Journal of Physiology—Renal Physiology, vol. 302, no. 12, pp. F1650–F1657, 2012. View at Publisher · View at Google Scholar · View at Scopus
  27. Y. Sakairi, Y. Ando, K. Tabei, E. Kusano, and Y. Asano, “Interleukin-1 inhibits sodium and water transport in rabbit cortical collecting duct,” American Journal of Physiology—Renal Fluid and Electrolyte Physiology, vol. 266, no. 4, pp. F674–F680, 1994. View at Google Scholar · View at Scopus
  28. S. I. Kreydiyyeh and R. Al-Sadi, “Interleukin-1β increases urine flow rate and inhibits protein expression of Na+/K+-ATPase in the rat jejunum and kidney,” Journal of Interferon & Cytokine Research, vol. 22, no. 10, pp. 1041–1048, 2002. View at Publisher · View at Google Scholar · View at Scopus
  29. S. I. Kreydiyyeh and R. Al-Sadi, “The signal transduction pathway that mediates the effect of interleukin-1 beta on the Na+-K+-ATPase in LLC-PK1 cells,” Pflügers Archiv, vol. 448, no. 2, pp. 231–238, 2004. View at Publisher · View at Google Scholar · View at Scopus
  30. M. Vinciguerra, U. Hasler, D. Mordasini et al., “Cytokines and sodium induce protein kinase A-dependent cell-surface Na, K-ATPase recruitment via dissociation of NF-κB/IκB/protein kinase A catalytic subunit complex in collecting duct principal cells,” Journal of the American Society of Nephrology, vol. 16, no. 9, pp. 2576–2585, 2005. View at Publisher · View at Google Scholar
  31. S. I. Kreydiyyeh and S. Markossian, “Tumor necrosis factor α down-regulates the Na+-K+ ATPase and the Na+-K+2Cl- cotransporter in the kidney cortex and medulla,” Cytokine, vol. 33, no. 3, pp. 138–144, 2006. View at Publisher · View at Google Scholar · View at Scopus
  32. C. Schmidt, K. Höcherl, F. Schweda, A. Kurtz, and M. Bucher, “Regulation of renal sodium transporters during severe inflammation,” Journal of the American Society of Nephrology, vol. 18, no. 4, pp. 1072–1083, 2007. View at Publisher · View at Google Scholar · View at Scopus
  33. S. Battula, S. Hao, P. L. Pedraza, C. T. Stier, and N. R. Ferreri, “Tumor necrosis factor-α is an endogenous inhibitor of Na+-K+-2Cl cotransporter (NKCC2) isoform a in the thick ascending limb,” American Journal of Physiology—Renal Physiology, vol. 301, no. 1, pp. F94–F100, 2011. View at Publisher · View at Google Scholar · View at Scopus
  34. N. V. Kamat, S. R. Thabet, L. Xiao et al., “Renal transporter activation during angiotensin-II hypertension is blunted in interferon-γ−/− and interleukin-17A−/− mice,” Hypertension, vol. 65, no. 3, pp. 569–576, 2015. View at Publisher · View at Google Scholar
  35. B. Viviani, F. Gardoni, and M. Marinovich, “Cytokines and neuronal ion channels in health and disease,” International Review of Neurobiology, vol. 82, pp. 247–263, 2007. View at Publisher · View at Google Scholar · View at Scopus
  36. K. Nakamura, Y. Komagiri, T. Kojo, and M. Kubokawa, “Effects of cytokines on activity of an inwardly rectifying K+ channel in cultured human proximal tubule cells,” The Journal of the Iwate Medical Association, vol. 59, no. 5, pp. 375–385, 2007. View at Google Scholar
  37. K. Nakamura, Y. Komagiri, T. Kojo, and M. Kubokawa, “Delayed and acute effects of interferon-γ on activity of an inwardly rectifying K+ channel in cultured human proximal tubule cells,” American Journal of Physiology—Renal Physiology, vol. 296, no. 1, pp. F46–F53, 2009. View at Publisher · View at Google Scholar · View at Scopus
  38. K. Nakamura, Y. Komagiri, and M. Kubokawa, “Interleukin-1β suppresses activity of an inwardly rectifying K+ channel in human renal proximal tubule cells,” Journal of Physiological Sciences, vol. 63, no. 5, pp. 377–387, 2013. View at Publisher · View at Google Scholar · View at Scopus
  39. K. Nakamura, J. Hirano, and M. Kubokawa, “An ATP-regulated and pH-sensitive inwardly rectifying K+ channel in cultured human proximal tubule cells,” Japanese Journal of Physiology, vol. 51, no. 4, pp. 523–530, 2001. View at Publisher · View at Google Scholar · View at Scopus
  40. K. Nakamura, J. Hirano, and M. Kubokawa, “Regulation of an inwardly rectifying K+ channel by nitric oxide in cultured human proximal tubule cells,” American Journal of Physiology—Renal Physiology, vol. 287, no. 3, pp. F411–F417, 2004. View at Publisher · View at Google Scholar · View at Scopus
  41. M. Kubokawa, T. Kojo, Y. Komagiri, and K. Nakamura, “Role of calcineurin-mediated dephosphorylation in modulation of an inwardly rectifying K+ channel in human proximal tubule cells,” Journal of Membrane Biology, vol. 231, no. 2-3, pp. 79–92, 2009. View at Publisher · View at Google Scholar · View at Scopus
  42. K. L. Hamilton and D. C. Devor, “Basolateral membrane K+ channels in renal epithelial cells,” American Journal of Physiology—Renal Physiology, vol. 302, no. 9, pp. F1069–F1081, 2012. View at Publisher · View at Google Scholar · View at Scopus
  43. K. Nakamura, J. Hirano, S.-I. Itazawa, and M. Kubokawa, “Protein kinase G activates inwardly rectifying K+ channel in cultured human proximal tubule cells,” American Journal of Physiology—Renal Physiology, vol. 283, no. 4, pp. F784–F791, 2002. View at Publisher · View at Google Scholar · View at Scopus
  44. L. C. Platanias, “Mechanisms of type-I- and type-II-interferon-mediated signalling,” Nature Reviews Immunology, vol. 5, no. 5, pp. 375–386, 2005. View at Publisher · View at Google Scholar · View at Scopus
  45. P. Lipp and G. Reither, “Protein kinase C: the ‘masters’ of calcium and lipid,” Cold Spring Harbor Perspectives in Biology, vol. 3, no. 7, Article ID a004556, 2011. View at Google Scholar · View at Scopus
  46. C. R. Plata-Salamán and J. M. H. Ffrench-Mullen, “Interleukin-1β inhibits Ca2+ channel currents in hippocampal neurons through protein kinase C,” European Journal of Pharmacology: Molecular Pharmacology, vol. 266, no. 1, pp. 1–10, 1994. View at Publisher · View at Google Scholar · View at Scopus
  47. J. Y. Choi, Y.-S. Choi, S. J. Kim, E. J. Son, H. S. Choi, and J.-H. Yoon, “Interleukin-1β suppresses epithelial sodium channel β-subunit expression and ENaC-dependent fluid absorption in human middle ear epithelial cells,” European Journal of Pharmacology, vol. 567, no. 1-2, pp. 19–25, 2007. View at Publisher · View at Google Scholar · View at Scopus
  48. E. G. Cafferata, A. M. González-Guerrico, L. Giordano, O. H. Pivetta, and T. A. Santa-Coloma, “Interleukin-1β regulates CFTR expression in human intestinal T84 cells,” Biochimica et Biophysica Acta, vol. 1500, no. 2, pp. 241–248, 2000. View at Publisher · View at Google Scholar · View at Scopus
  49. P. K. Chatterjee, G. M. Hawksworth, and J. S. McLay, “Cytokine-stimulated nitric oxide production in the human renal proximal tubule and its modulation by natriuretic peptides: a novel immunomodulatory mechanism?” Experimental Nephrology, vol. 7, no. 5-6, pp. 438–448, 1999. View at Publisher · View at Google Scholar · View at Scopus
  50. C. Huang, M. L. Day, P. Poronnik, C. A. Pollock, and X.-M. Chen, “Inhibition of KCa3.1 suppresses TGF-β1 induced MCP-1 expression in human proximal tubular cells through Smad3, p38 and ERK1/2 signaling pathways,” The International Journal of Biochemistry & Cell Biology, vol. 47, no. 1, pp. 1–10, 2014. View at Publisher · View at Google Scholar · View at Scopus
  51. H. Wulff and N. A. Castle, “Therapeutic potential of KCa3.1 blockers: recent advances and promising trends,” Expert Review of Clinical Pharmacology, vol. 3, no. 3, pp. 385–396, 2010. View at Publisher · View at Google Scholar · View at Scopus
  52. Y. Wei, E. Babilonia, P. L. Pedraza, N. R. Ferreri, and W.-H. Wang, “Acute application of TNF stimulates apical 70-pS K+ channels in the thick ascending limb of rat kidney,” American Journal of Physiology—Renal Physiology, vol. 285, no. 3, pp. F491–F497, 2003. View at Publisher · View at Google Scholar · View at Scopus
  53. D. Li, Y. Wei, and W.-H. Wang, “Dietary K intake regulates the response of apical K channels to adenosine in the thick ascending limb,” American Journal of Physiology—Renal Physiology, vol. 287, no. 5, pp. F954–F959, 2004. View at Publisher · View at Google Scholar · View at Scopus
  54. M. Lu, X. Wang, and W. Wang, “Nitric oxide increases the activity of the apical 70-pS K+ channel in TAL of rat kidney,” American Journal of Physiology—Renal Physiology, vol. 274, no. 5, pp. F946–F950, 1998. View at Google Scholar · View at Scopus
  55. D. Wang, P. L. Pedraza, H. I. Abdullah, J. C. McGiff, and N. R. Ferreri, “Calcium-sensing receptor-mediated TNF production in medullary thick ascending limb cells,” American Journal of Physiology—Renal Physiology, vol. 283, no. 5, pp. F963–F970, 2002. View at Publisher · View at Google Scholar · View at Scopus
  56. H. J. Liu, Y. Wei, N. R. Fererri, A. Nasjletti, and W. H. Wang, “Vasopressin and PGE2 regulate activity of apical 70 pS K+ channel in thick ascending limb of rat kidney,” American Journal of Physiology—Cell Physiology, vol. 278, no. 5, pp. C905–C913, 2000. View at Google Scholar · View at Scopus
  57. M. I. Maldonado-Cervantes, O. G. Galicia, B. Moreno-Jaime et al., “Autocrine modulation of glucose transporter SGLT2 by IL-6 and TNF-α in LLC-PK1 cells,” Journal of Physiology and Biochemistry, vol. 68, no. 3, pp. 411–420, 2012. View at Publisher · View at Google Scholar · View at Scopus
  58. C. Schmidt, K. Höcherl, F. Schweda, and M. Bucher, “Proinflammatory cytokines cause down-regulation of renal chloride entry pathways during sepsis,” Critical Care Medicine, vol. 35, no. 9, pp. 2110–2119, 2007. View at Publisher · View at Google Scholar · View at Scopus
  59. C. Schmidt, K. Höcherl, and M. Bucher, “Regulation of renal glucose transporters during severe inflammation,” American Journal of Physiology—Renal Physiology, vol. 292, no. 2, pp. F804–F811, 2007. View at Publisher · View at Google Scholar · View at Scopus
  60. V. M. Radhakrishnan, P. Kojs, R. Ramalingam et al., “Experimental colitis is associated with transcriptional inhibition of Na+/Ca2+ exchanger isoform 1 (NCX1) expression by interferon γ in the renal distal convoluted tubules,” The Journal of Biological Chemistry, vol. 290, no. 14, pp. 8964–8974, 2015. View at Publisher · View at Google Scholar
  61. C. Schmidt, K. Höcherl, and M. Bucher, “Cytokine-mediated regulation of urea transporters during experimental endotoxemia,” American Journal of Physiology—Renal Physiology, vol. 292, no. 5, pp. F1479–F1489, 2007. View at Publisher · View at Google Scholar · View at Scopus
  62. G. Ramesh and W. B. Reeves, “Inflammatory cytokines in acute renal failure,” Kidney International, Supplement, vol. 66, no. 91, pp. S56–S61, 2004. View at Google Scholar · View at Scopus
  63. L. M. Ortega and A. Fornoni, “Role of cytokines in the pathogenesis of acute and chronic kidney disease, glomerulonephritis, and end-stage kidney disease,” International Journal of Interferon, Cytokine and Mediator Research, vol. 2, no. 1, pp. 49–62, 2010. View at Google Scholar · View at Scopus
  64. R. W. Schrier and W. Wang, “Acute renal failure and sepsis,” The New England journal of medicine, vol. 351, no. 2, pp. 159–169, 2004. View at Publisher · View at Google Scholar · View at Scopus
  65. E. Jonasch and F. G. Haluska, “Interferon in oncological practice: review of interferon biology, clinical applications, and toxicities,” Oncologist, vol. 6, no. 1, pp. 34–55, 2001. View at Publisher · View at Google Scholar · View at Scopus
  66. T. M. Phillips, “Interferon-alpha induces renal dysfunction and injury,” Current Opinion in Nephrology and Hypertension, vol. 5, no. 4, pp. 380–383, 1996. View at Publisher · View at Google Scholar · View at Scopus
  67. D. A. Vesey, C. Cheung, Z. Endre, G. Gobé, and D. W. Johnson, “Role of protein kinase C and oxidative stress in interleukin-1β-induced human proximal tubule cell injury and fibrogenesis,” Nephrology, vol. 10, no. 1, pp. 73–80, 2005. View at Publisher · View at Google Scholar · View at Scopus
  68. H. H. Nietsch, M. W. Roe, J. F. Fiekers, A. L. Moore, and S. D. Lidofsky, “Activation of potassium and chloride channels by tumor necrosis factor α. Role in liver cell death,” The Journal of Biological Chemistry, vol. 275, no. 27, pp. 20556–20561, 2000. View at Publisher · View at Google Scholar · View at Scopus
  69. J. Wang, H. Wang, Y. Zhang, H. Gao, S. Nattel, and Z. Wang, “Impairment of HERG K+ channel function by tumor necrosis factor-α: role of reactive oxygen species as a mediator,” The Journal of Biological Chemistry, vol. 279, no. 14, pp. 13289–13292, 2004. View at Publisher · View at Google Scholar · View at Scopus
  70. V. Diwan, G. Gobe, and L. Brown, “Glibenclamide improves kidney and heart structure and function in the adenine-diet model of chronic kidney disease,” Pharmacological Research, vol. 79, pp. 104–110, 2014. View at Publisher · View at Google Scholar · View at Scopus
  71. C. Huang, C. A. Pollock, and X.-M. Chen, “High glucose induces CCL20 in proximal tubular cells via activation of the KCa3.1 channel,” PLoS ONE, vol. 9, no. 4, Article ID e95173, 2014. View at Publisher · View at Google Scholar · View at Scopus
  72. C. Huang, S. Shen, Q. Ma et al., “Blockade of KCa3.1 ameliorates renal fibrosis through the TGF-β1/smad pathway in diabetic mice,” Diabetes, vol. 62, no. 8, pp. 2923–2934, 2013. View at Publisher · View at Google Scholar · View at Scopus
  73. M. A. Garcia, R. Meca, D. Leite, and M. A. Boim, “Effect of renal ischemia/reperfusion on gene expression of a pH-sensitive K+ channel,” Nephron Physiology, vol. 106, no. 1, pp. 1–7, 2007. View at Publisher · View at Google Scholar · View at Scopus
  74. S. Shimizu, M. Saito, Y. Kinoshita et al., “Nicorandil ameliorates ischaemia-reperfusion injury in the rat kidney,” British Journal of Pharmacology, vol. 163, no. 2, pp. 272–282, 2011. View at Publisher · View at Google Scholar · View at Scopus
  75. Y.-J. Zhang, A.-Q. Zhang, X.-X. Zhao, Z.-L. Tian, and L. Yao, “Nicorandil protects against ischaemia-reperfusion injury in newborn rat kidney,” Pharmacology, vol. 92, no. 5-6, pp. 245–256, 2014. View at Publisher · View at Google Scholar · View at Scopus
  76. E. Grossini, C. Molinari, P. Pollesello et al., “Levosimendan protection against kidney ischemia/reperfusion injuries in anesthetized pigs,” Journal of Pharmacology and Experimental Therapeutics, vol. 342, no. 2, pp. 376–388, 2012. View at Publisher · View at Google Scholar · View at Scopus
  77. L. C. Penning, G. Denecker, D. Vercammen, W. Declercq, R. G. Schipper, and P. Vandenabeele, “A role for potassium in TNF-induced apoptosis and gene-induction in human and rodent tumour cell lines,” Cytokine, vol. 12, no. 6, pp. 747–750, 2000. View at Publisher · View at Google Scholar · View at Scopus
  78. F. Lang, E. Shumilina, M. Ritter, E. Gulbins, A. Vereninov, and S. M. Huber, “Ion channels and cell volume in regulation of cell proliferation and apoptotic cell death,” Contributions to Nephrology, vol. 152, pp. 142–160, 2006. View at Publisher · View at Google Scholar · View at Scopus
  79. G. Shapovalov, V. Lehen'kyi, R. Skryma, and N. Prevarskaya, “TRP channels in cell survival and cell death in normal and transformed cells,” Cell Calcium, vol. 50, no. 3, pp. 295–302, 2011. View at Publisher · View at Google Scholar · View at Scopus