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Mediators of Inflammation
Volume 2015, Article ID 409347, 6 pages
Review Article

In Vivo Experiments with Dental Pulp Stem Cells for Pulp-Dentin Complex Regeneration

1Department of Conservative Dentistry, Gangnam Severance Dental Hospital, College of Dentistry, Yonsei University, Seoul 06273, Republic of Korea
2Department of Conservative Dentistry, Hallym Hospital, Hallym University, Anyang 14068, Republic of Korea
3Microscope Center, Department of Conservative Dentistry and Oral Science Research Center, College of Dentistry, Yonsei University, Seoul 03722, Republic of Korea

Received 1 July 2015; Accepted 10 November 2015

Academic Editor: Robert M. Love

Copyright © 2015 Sunil Kim et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


In recent years, many studies have examined the pulp-dentin complex regeneration with DPSCs. While it is important to perform research on cells, scaffolds, and growth factors, it is also critical to develop animal models for preclinical trials. The development of a reproducible animal model of transplantation is essential for obtaining precise and accurate data in vivo. The efficacy of pulp regeneration should be assessed qualitatively and quantitatively using animal models. This review article sought to introduce in vivo experiments that have evaluated the potential of dental pulp stem cells for pulp-dentin complex regeneration. According to a review of various researches about DPSCs, the majority of studies have used subcutaneous mouse and dog teeth for animal models. There is no way to know which animal model will reproduce the clinical environment. If an animal model is developed which is easier to use and is useful in more situations than the currently popular models, it will be a substantial aid to studies examining pulp-dentin complex regeneration.