A Novel Minimal Invasive Mouse Model of Extracorporeal Circulation

Figure 4

Lung function and tissue morphology after ECC. Mice were treated as described in Figure 2, and lung histopathology and arterial blood gas analysis were performed at 60 min after the end of ECC. (a) The upper lobe of the left lung was fixed in formaldehyde, sectioned, and stained with hematoxylin and eosin (; magnification, 40x). (b) The oxygenation index was calculated as FiO₂/PaO₂. (c) Acute lung injury was scored as described in Section 2. versus Sham, ^# versus Naïve.

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