Differential Associations between CDH13 Genotypes, Adiponectin Levels, and Circulating Levels of Cellular Adhesive Molecules
Table 4
Association between CDH13 rs12051272 genotypes and adiposity status and adiponectin levels and inflammatory marker levels.
Genotype
GG ()
GT ()
TT ()
Β (95% CI)
P1
P2
P3
Anthropology
Age (years)
44.6 ± 8.2
45.3 ± 10.5
44.8 ± 9.3
Body mass index (kg/m2)
23.7 ± 3.0
24.4 ± 3.8
25.0 ± 3.8
0.012
1.07 (0.12–2.02)
0.027
Waist circumference (cm)
83.5 ± 8.8
84.8 ± 10.0
88.3 ± 11.0
1.31 × 10−4
0.004
0.011
4.68 (2.17–7.19)
2.71 × 10−4
0.003
0.008
Adiponectin (mg/L)
8.58 ± 5.44
6.40 ± 3.98
5.15 ± 4.38
2.7 × 10−10
7.45 × 10−9
−0.20 (−0.27 to −0.13)
2.57 × 10−8
3.52 × 10−7
Inflammation marker
CRP (mg/L)
1.10 ± 1.51
0.88 ± 1.06
1.44 ± 1.60
0.018
0.163
0.702
0.18 (0.04–0.31)
0.010
0.084
0.395
Fibrinogen (mg/dL)
261.7 ± 71.6
261.4 ± 62.8
273.2 ± 79.7
0.241
0.463
0.646
11.59 (−7.19–30.38)
0.226
0.412
0.563
sE-selectin (ng/mL)
52.8 ± 21.7
49.76 ± 20.70
65.08 ± 47.16
0.018
0.083
0.327
0.07 (0.02–0.12)
0.009
0.039
0.160
sP-selectin (ng/mL)
137.6 ± 104.8
132.4 ± 119.7
165.0 ± 137.7
0.093
0.116
0.230
0.08 (−0.0004–0.16)
0.051
0.064
0.126
sVCAM1 (ng/mL)
485.9 ± 107.4
479.2 ± 105.5
537.6 ± 263.7
0.027
0.014
0.001
0.03 (0.01–0.06)
0.019
0.010
0.001
sICAM1 (ng/mL)
236.8 ± 95.2
235.3 ± 89.8
286.1 ± 16.00
0.024
0.058
0.171
0.06 (0.01–0.11)
0.016
0.037
0.103
sTNFR2 (pg/mL)
3222.1 ± 900.7
3230.7 ± 939.5
3411.4 ± 964.8
0.125
0.194
0.193
0.03 (−0.01–0.06)
0.121
0.180
0.180
MCP1 (pg/mL)
70.8 ± 61.6
79.1 ± 65.1
65.0 ± 33.2
0.914
0.845
0.844
−0.02 (−0.10–0.06)
0.618
0.564
0.558
IL6 (pg/L)
4.7 ± 10.0
3.4 ± 4.7
4.8 ± 5.9
0.065
0.129
0.165
0.12 (0.002–0.0.24)
0.046
0.221
0.107
MMP1 (pg/mL)
518.1 ± 1341.1
472.0 ± 1174.5
446.2 ± 675.8
0.221
0.232
0.240
0.09 (−0.04–0.22)
0.186
0.197
0.204
MMP2 (ng/mL)
124.4 ± 35.4
127.6 ± 44.7
123.8 ± 46.0
0.749
0.863
0.877
−0.02 (−0.05–0.02)
0.356
0.437
0.748
MMP9 (ng/mL)
145.9 ± 122.3
139.2 ± 97.6
156.5 ± 131.0
0.359
0.504
0.685
16.37 (−15.44–48.19)
0.313
0.429
0.574
SAA (mg/L)
6.32 ± 13.92
5.35 ± 17.77
6.35 ± 11.80
0.618
0.865
0.597
0.05 (−0.09–0.19)
0.462
0.653
0.439
Abbreviations as in Table 1. = number; CRP: excluded subjects with CRP levels >10 mg/L; value adjusted for age and sex; value adjusted for age, sex, BMI, and smoking status; value further adjusted for adiponectin levels; sICAM1: only subjects with ICAM1 rs5491 AA genotype selected; data was analyzed in recessive model (GG + GTversus TT).
