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Mediators of Inflammation
Volume 2015 (2015), Article ID 657907, 9 pages
http://dx.doi.org/10.1155/2015/657907
Clinical Study

Systemic Autoimmune, Rheumatic Diseases and Coinciding Psoriasis: Data from a Large Single-Centre Registry and Review of the Literature

1National Institute of Rheumatology and Physiotherapy, Frankel Leó Utca 38-40, Budapest 1023, Hungary
2Institute of Immunology, Rikshospitalet, Oslo University Hospital, 0027 Oslo, Norway

Received 14 September 2014; Accepted 10 November 2014

Academic Editor: Yrjö Konttinen

Copyright © 2015 Anna Bazsó et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Psoriasis is a systemic immune-inflammatory disease characterized by chronic or recurrent skin symptoms, psoriatic arthritis, enthesopathy, and uveitis. Psoriasis has recently been published to appear with various autoimmune disorders, but the coexistence has been systematically reviewed by only few studies until now. In the present study, charts and electronic database of 4344 patients with various systemic autoimmune disorders, under regular medical control at our department, were reviewed retrospectively searching for association with psoriasis. Hereby, we demonstrate 25 psoriatic patients coinciding with various systemic autoimmune diseases. The coexistence of psoriasis and autoimmune diseases resulted in the worsening of the clinical outcome of the autoimmune diseases as indicated by higher frequency and dosages of glucocorticoid use, need for biologicals, and other comorbidities. These results suggest common environmental and genetic background as well as therapeutic possibilities in the future.