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Mediators of Inflammation
Volume 2015, Article ID 670580, 10 pages
Review Article

Circulating Cytokine Levels as Markers of Inflammation in Philadelphia Negative Myeloproliferative Neoplasms: Diagnostic and Prognostic Interest

1UF de Pathologie Moléculaire, Département d’Anatomie et Cytologie Pathologiques, CHU Grenoble, 38043 Grenoble Cedex 09, France
2Equipe TheRex Laboratoire TIMC-IMAG-UMR5525 CNRS, Université Grenoble Alpes, France
3Institute of Pathology, Hannover Medical School, Carl-Neuberg-Strasse 1, 30625 Hannover, Germany
4Laboratoire d’Hématologie Cellulaire, Institut de Biologie et Pathologie, CHU Grenoble, 38043 Grenoble Cedex 09, France

Received 3 July 2015; Accepted 6 August 2015

Academic Editor: Hans Carl Hasselbalch

Copyright © 2015 Julie Mondet et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Cytokines are well known mediators of numerous physiological and pathological processes. They contribute to the regulation of normal hematopoiesis but increasing data suggest that they also have a clinical impact in some hematopoietic malignancies. In particular, there is evidence that cytokines are implicated in the functional symptoms of Philadelphia negative myeloproliferative neoplasms (Ph− MPNs), suggesting that evaluation of circulating levels of cytokines could be of clinical interest for the characterization of patients at the time of diagnosis and for disease prognosis. In this review, we present the current knowledge on alteration of circulating cytokine profiles in MPNs and their role in myelofibrosis pathogenesis. Phenotypic correlation, prognostic value of cytokines, and impact of JAK inhibitors are also discussed.