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Mediators of Inflammation
Volume 2015, Article ID 794143, 12 pages
http://dx.doi.org/10.1155/2015/794143
Review Article

An Overview of Pathogen Recognition Receptors for Innate Immunity in Dental Pulp

1Department of Conservative Dentistry, Kyung Hee University Dental Hospital at Gangdong, Seoul, Republic of Korea
2School of Dentistry, University of Western Australia, Nedlands, WA, Australia
3Department of Conservative Dentistry, Graduate School, Kyung Hee University, Seoul, Republic of Korea
4Department of Pharmacology, School of Dentistry, Kyung Hee University, Seoul, Republic of Korea
5Oral Biology Research Institute, School of Dentistry, Kyung Hee University, Seoul, Republic of Korea
6Department of Maxillofacial Tissue Regeneration, School of Dentistry and Institute of Oral Biology, Kyung Hee University, Seoul, Republic of Korea
7Department of Conservative Dentistry, School of Dentistry, Kyung Hee University, 1 Hoegidong, Dongdaemoongu, Seoul 130-701, Republic of Korea

Received 1 July 2015; Accepted 28 September 2015

Academic Editor: Anshu Agrawal

Copyright © 2015 Ji-Hyun Jang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. S. Akira, S. Uematsu, and O. Takeuchi, “Pathogen recognition and innate immunity,” Cell, vol. 124, no. 4, pp. 783–801, 2006. View at Publisher · View at Google Scholar · View at Scopus
  2. T. Kawai and S. Akira, “The roles of TLRs, RLRs and NLRs in pathogen recognition,” International Immunology, vol. 21, no. 4, pp. 317–337, 2009. View at Publisher · View at Google Scholar · View at Scopus
  3. O. Takeuchi and S. Akira, “Pattern recognition receptors and inflammation,” Cell, vol. 140, no. 6, pp. 805–820, 2010. View at Publisher · View at Google Scholar · View at Scopus
  4. K. Schroder and J. Tschopp, “The inflammasomes,” Cell, vol. 140, no. 6, pp. 821–832, 2010. View at Publisher · View at Google Scholar · View at Scopus
  5. W. He, T. Qu, Q. Yu et al., “LPS induces IL-8 expression through TLR4, MyD88, NF-κB and MAPK pathways in human dental pulp stem cells,” International Endodontic Journal, vol. 46, no. 2, pp. 128–136, 2013. View at Publisher · View at Google Scholar · View at Scopus
  6. S.-I. Lee, G.-T. Kim, H. J. Kim, S.-H. Park, and E.-C. Kim, “NOD2 mediates odontoblast differentiation and RANKL expression,” Journal of Dental Research, vol. 93, no. 7, pp. 678–684, 2014. View at Publisher · View at Google Scholar · View at Scopus
  7. K. J. Heyeraas and I. Kvinnsland, “Tissue pressure and blood flow in pulpal inflammation,” Proceedings of the Finnish Dental Society, vol. 88, supplement 1, pp. 393–401, 1992. View at Google Scholar · View at Scopus
  8. H. J. Van Hassel, “Physiology of the human dental pulp,” Oral Surgery, Oral Medicine, Oral Pathology, vol. 32, no. 1, pp. 126–134, 1971. View at Publisher · View at Google Scholar · View at Scopus
  9. K. J. Heyeraas and E. Berggreen, “Interstitial fluid pressure in normal and inflamed pulp,” Critical Reviews in Oral Biology and Medicine, vol. 10, no. 3, pp. 328–336, 1999. View at Publisher · View at Google Scholar · View at Scopus
  10. S. Kim and J. Dörscher-Kim, “Hemodynamic regulation of the dental pulp in a low compliance environment,” Journal of Endodontics, vol. 15, no. 9, pp. 404–408, 1989. View at Publisher · View at Google Scholar · View at Scopus
  11. E. Couve, “Ultrastructural changes during the life cycle of human odontoblasts,” Archives of Oral Biology, vol. 31, no. 10, pp. 643–651, 1986. View at Publisher · View at Google Scholar · View at Scopus
  12. K. M. Hargreaves, H. E. Goodis, and F. R. Tay, Seltzer and Bender's Dental Pulp, Quintessence, 2nd edition, 2012.
  13. M. Goldberg, J.-C. Farges, S. Lacerda-Pinheiro et al., “Inflammatory and immunological aspects of dental pulp repair,” Pharmacological Research, vol. 58, no. 2, pp. 137–147, 2008. View at Publisher · View at Google Scholar · View at Scopus
  14. C. Yu and P. V. Abbott, “An overview of the dental pulp: its functions and responses to injury,” Australian Dental Journal, vol. 52, no. s4, p. S16, 2007. View at Publisher · View at Google Scholar · View at Scopus
  15. B. H. Sen, B. Piskin, and T. Demirci, “Observation of bacteria and fungi in infected root canals and dentinal tubules by SEM,” Endodontics & Dental Traumatology, vol. 11, no. 1, pp. 6–9, 1995. View at Publisher · View at Google Scholar · View at Scopus
  16. K. Hirao, H. Yumoto, K. Takahashi, K. Mukai, T. Nakanishi, and T. Matsuo, “Roles of TLR2, TLR4, NOD2, and NOD1 in pulp fibroblasts,” Journal of Dental Research, vol. 88, no. 8, pp. 762–767, 2009. View at Publisher · View at Google Scholar · View at Scopus
  17. T. Adachi, T. Nakanishi, H. Yumoto et al., “Caries-related bacteria and cytokines induce CXCL10 in dental pulp,” Journal of Dental Research, vol. 86, no. 12, pp. 1217–1222, 2007. View at Publisher · View at Google Scholar · View at Scopus
  18. Y.-Y. Lee, C.-H. Chan, S.-L. Hung, Y.-C. Chen, Y.-H. Lee, and S.-F. Yang, “Up-regulation of nucleotide-binding oligomerization domain 1 in inflamed human dental pulp,” Journal of Endodontics, vol. 37, no. 10, pp. 1370–1375, 2011. View at Publisher · View at Google Scholar · View at Scopus
  19. J. E. Baik, Y. H. Ryu, J. Y. Han et al., “Lipoteichoic acid partially contributes to the inflammatory responses to Enterococcus faecalis,” Journal of Endodontics, vol. 34, no. 8, pp. 975–982, 2008. View at Publisher · View at Google Scholar · View at Scopus
  20. B.-D. Choi, S.-J. Jeong, G. Wang et al., “Temporal induction of secretory leukocyte protease inhibitor (SLPI) in odontoblasts by lipopolysaccharide and wound infection,” Journal of Endodontics, vol. 35, no. 7, pp. 997–1002, 2009. View at Publisher · View at Google Scholar · View at Scopus
  21. R. M. Love and H. F. Jenkinson, “Invasion of dentinal tubules by oral bacteria,” Critical Reviews in Oral Biology and Medicine, vol. 13, no. 2, pp. 171–183, 2002. View at Publisher · View at Google Scholar · View at Scopus
  22. B. J. Paster, I. Olsen, J. A. Aas, and F. E. Dewhirst, “The breadth of bacterial diversity in the human periodontal pocket and other oral sites,” Periodontology 2000, vol. 42, no. 1, pp. 80–87, 2006. View at Publisher · View at Google Scholar · View at Scopus
  23. P. E. Kolenbrander, R. N. Andersen, D. S. Blehert, P. G. Egland, J. S. Foster, and R. J. Palmer Jr., “Communication among oral bacteria,” Microbiology and Molecular Biology Reviews, vol. 66, no. 3, pp. 486–505, 2002. View at Publisher · View at Google Scholar · View at Scopus
  24. J. A. Aas, B. J. Paster, L. N. Stokes, I. Olsen, and F. E. Dewhirst, “Defining the normal bacterial flora of the oral cavity,” Journal of Clinical Microbiology, vol. 43, no. 11, pp. 5721–5732, 2005. View at Publisher · View at Google Scholar · View at Scopus
  25. S. S. Socransky, A. D. Haffajee, C. Smith et al., “Use of checkerboard DNA-DNA hybridization to study complex microbial ecosystems,” Oral Microbiology and Immunology, vol. 19, no. 6, pp. 352–362, 2004. View at Publisher · View at Google Scholar · View at Scopus
  26. X. Li, K. M. Kolltveit, L. Tronstad, and I. Olsen, “Systemic diseases caused by oral infection,” Clinical Microbiology Reviews, vol. 13, no. 4, pp. 547–558, 2000. View at Publisher · View at Google Scholar · View at Scopus
  27. C.-L. Hahn and F. R. Liewehr, “Innate immune responses of the dental pulp to caries,” Journal of Endodontics, vol. 33, no. 6, pp. 643–651, 2007. View at Publisher · View at Google Scholar · View at Scopus
  28. K. Crozat, E. Vivier, and M. Dalod, “Crosstalk between components of the innate immune system: promoting anti-microbial defenses and avoiding immunopathologies,” Immunological Reviews, vol. 227, no. 1, pp. 129–149, 2009. View at Publisher · View at Google Scholar · View at Scopus
  29. J. Parkin and B. Cohen, “An overview of the immune system,” The Lancet, vol. 357, no. 9270, pp. 1777–1789, 2001. View at Publisher · View at Google Scholar · View at Scopus
  30. J. Banchereau and R. M. Steinman, “Dendritic cells and the control of immunity,” Nature, vol. 392, no. 6673, pp. 245–252, 1998. View at Publisher · View at Google Scholar · View at Scopus
  31. M.-J. Staquet, F. Carrouel, J.-F. Keller et al., “Pattern-recognition receptors in pulp defense,” Advances in Dental Research, vol. 23, no. 3, pp. 296–301, 2011. View at Publisher · View at Google Scholar · View at Scopus
  32. S. H. Durand, V. Flacher, A. Roméas et al., “Lipoteichoic acid increases TLR and functional chemokine expression while reducing dentin formation in in vitro differentiated human odontoblasts,” The Journal of Immunology, vol. 176, no. 5, pp. 2880–2887, 2006. View at Publisher · View at Google Scholar · View at Scopus
  33. H.-W. Jiang, W. Zhang, B.-P. Ren, J.-F. Zeng, and J.-Q. Ling, “Expression of toll like receptor 4 in normal human odontoblasts and dental pulp tissue,” Journal of Endodontics, vol. 32, no. 8, pp. 747–751, 2006. View at Publisher · View at Google Scholar · View at Scopus
  34. N. Mutoh, N. Tani-Ishii, K. Tsukinoki, K. Chieda, and K. Watanabe, “Expression of toll-like receptor 2 and 4 in dental pulp,” Journal of Endodontics, vol. 33, no. 10, pp. 1183–1186, 2007. View at Publisher · View at Google Scholar · View at Scopus
  35. L. G. Marcato, A. P. Ferlini, R. C. F. Bonfim et al., “The role of Toll-like receptors 2 and 4 on reactive oxygen species and nitric oxide production by macrophage cells stimulated with root canal pathogens,” Oral Microbiology and Immunology, vol. 23, no. 5, pp. 353–359, 2008. View at Publisher · View at Google Scholar · View at Scopus
  36. N. Mutoh, H. Watabe, K. Chieda, and N. Tani-Ishii, “Expression of Toll-like receptor 2 and 4 in inflamed pulp in severe combined immunodeficiency mice,” Journal of Endodontics, vol. 35, no. 7, pp. 975–980, 2009. View at Publisher · View at Google Scholar · View at Scopus
  37. O. V. Horst, K. A. Tompkins, S. R. Coats, P. H. Braham, R. P. Darveau, and B. A. Dale, “TGF-β1 inhibits TLR-mediated odontoblast responses to oral bacteria,” Journal of Dental Research, vol. 88, no. 4, pp. 333–338, 2009. View at Publisher · View at Google Scholar · View at Scopus
  38. Z.-M. Lin, Z. Song, W. Qin et al., “Expression of nucleotide-binding oligomerization domain 2 in normal human dental pulp cells and dental pulp tissues,” Journal of Endodontics, vol. 35, no. 6, pp. 838–842, 2009. View at Publisher · View at Google Scholar · View at Scopus
  39. J.-F. Keller, F. Carrouel, E. Colomb et al., “Toll-like receptor 2 activation by lipoteichoic acid induces differential production of pro-inflammatory cytokines in human odontoblasts, dental pulp fibroblasts and immature dendritic cells,” Immunobiology, vol. 215, no. 1, pp. 53–59, 2010. View at Publisher · View at Google Scholar · View at Scopus
  40. C. Park, S. Y. Lee, H. J. Kim, K. Park, J. S. Kim, and S. J. Lee, “Synergy of TLR2 and H1R on Cox-2 activation in pulpal cells,” Journal of Dental Research, vol. 89, no. 2, pp. 180–185, 2010. View at Publisher · View at Google Scholar · View at Scopus
  41. T. M. Botero, J. S. Son, D. Vodopyanov, M. Hasegawa, C. E. Shelburne, and J. E. Nör, “MAPK signaling is required for LPS-induced VEGF in pulp stem cells,” Journal of Dental Research, vol. 89, no. 3, pp. 264–269, 2010. View at Publisher · View at Google Scholar · View at Scopus
  42. J.-C. Farges, F. Carrouel, J.-F. Keller et al., “Cytokine production by human odontoblast-like cells upon Toll-like receptor-2 engagement,” Immunobiology, vol. 216, no. 4, pp. 513–517, 2011. View at Publisher · View at Google Scholar · View at Scopus
  43. J.-F. Keller, F. Carrouel, M.-J. Staquet et al., “Expression of NOD2 is increased in inflamed human dental pulps and lipoteichoic acid-stimulated odontoblast-like cells,” Innate Immunity, vol. 17, no. 1, pp. 29–34, 2010. View at Publisher · View at Google Scholar · View at Scopus
  44. Z. Song, Z. Lin, F. He et al., “NLRP3 is expressed in human dental pulp cells and tissues,” Journal of Endodontics, vol. 38, no. 12, pp. 1592–1597, 2012. View at Publisher · View at Google Scholar · View at Scopus
  45. R. A. B. da Silva, P. D. F. Ferreira, A. de Rossi, P. Nelson-Filho, and L. A. B. Silva, “Toll-like receptor 2 knockout mice showed increased periapical lesion size and osteoclast number,” Journal of Endodontics, vol. 38, no. 6, pp. 803–813, 2012. View at Publisher · View at Google Scholar · View at Scopus
  46. F. Carrouel, M.-J. Staquet, J.-F. Keller et al., “Lipopolysaccharide-binding protein inhibits toll-like receptor 2 activation by lipoteichoic acid in human odontoblast-like cells,” Journal of Endodontics, vol. 39, no. 8, pp. 1008–1014, 2013. View at Publisher · View at Google Scholar · View at Scopus
  47. J. Zhang, Q. L. Zhu, P. Huang et al., “CpG ODN-induced matrix metalloproteinase-13 expression is mediated via activation of the ERK and NF-kappaB signalling pathways in odontoblast cells,” International Endodontic Journal, vol. 46, no. 7, pp. 666–674, 2013. View at Publisher · View at Google Scholar · View at Scopus
  48. Y. Wang, S. Zhai, H. Wang et al., “Absent in melanoma 2 (AIM2) in rat dental pulp mediates the inflammatory response during pulpitis,” Journal of Endodontics, vol. 39, no. 11, pp. 1390–1394, 2013. View at Publisher · View at Google Scholar · View at Scopus
  49. F. P. Cardoso, S. A. de Faria Amormino, W. O. Dutra, A. P. Ribeiro Sobrinho, and P. R. Moreira, “Methylation pattern of the CD14 and TLR2 genes in human dental pulp,” Journal of Endodontics, vol. 40, no. 3, pp. 384–386, 2014. View at Publisher · View at Google Scholar · View at Scopus
  50. W. He, Z. Wang, Z. Zhou et al., “Lipopolysaccharide enhances Wnt5a expression through toll-like receptor 4, myeloid differentiating factor 88, phosphatidylinositol 3-OH kinase/AKT and nuclear factor kappa B pathways in human dental pulp stem cells,” Journal of Endodontics, vol. 40, no. 1, pp. 69–75, 2014. View at Publisher · View at Google Scholar · View at Scopus
  51. X. Feng, G. Feng, J. Xing et al., “Repeated lipopolysaccharide stimulation promotes cellular senescence in human dental pulp stem cells (DPSCs),” Cell and Tissue Research, vol. 356, no. 2, pp. 369–380, 2014. View at Publisher · View at Google Scholar
  52. S. Liu, Q. Li, and Y. Liu, “Immunohistochemical localization of NALP3 inflammasome in experimental periapical lesions,” International Endodontic Journal, vol. 47, no. 10, pp. 949–957, 2014. View at Publisher · View at Google Scholar · View at Scopus
  53. V. Pääkkönen, P. Rusanen, J. Hagström, and L. Tjäderhane, “Mature human odontoblasts express virus-recognizing toll-like receptors,” International Endodontic Journal, vol. 47, no. 10, pp. 934–941, 2014. View at Publisher · View at Google Scholar · View at Scopus
  54. S.-I. Lee, S.-K. Kang, H.-J. Jung, Y.-H. Chun, Y.-D. Kwon, and E.-C. Kim, “Muramyl dipeptide activates human beta defensin 2 and pro-inflammatory mediators through Toll-like receptors and NLRP3 inflammasomes in human dental pulp cells,” Clinical Oral Investigations, vol. 19, no. 6, pp. 1419–1428, 2014. View at Publisher · View at Google Scholar · View at Scopus
  55. A. Zhang, P. Wang, X. Ma et al., “Mechanisms that lead to the regulation of NLRP3 inflammasome expression and activation in human dental pulp fibroblasts,” Molecular Immunology, vol. 66, no. 2, pp. 253–262, 2015. View at Publisher · View at Google Scholar
  56. C. Hashimoto, K. L. Hudson, and K. V. Anderson, “The Toll gene of drosophila, required for dorsal-ventral embryonic polarity, appears to encode a transmembrane protein,” Cell, vol. 52, no. 2, pp. 269–279, 1988. View at Publisher · View at Google Scholar · View at Scopus
  57. B. Lemaitre, E. Nicolas, L. Michaut, J.-M. Reichhart, and J. A. Hoffmann, “The dorsoventral regulatory gene cassette spatzle/Toll/Cactus controls the potent antifungal response in Drosophila adults,” Cell, vol. 86, no. 6, pp. 973–983, 1996. View at Publisher · View at Google Scholar · View at Scopus
  58. D. Kabelitz, D. Wesch, and H.-H. Oberg, “Regulation of regulatory T cells: role of dendritic cells and toll-like receptors,” Critical Reviews in Immunology, vol. 26, no. 4, pp. 291–306, 2006. View at Publisher · View at Google Scholar · View at Scopus
  59. T. Kawai and S. Akira, “Regulation of innate immune signalling pathways by the tripartite motif (TRIM) family proteins,” EMBO Molecular Medicine, vol. 3, no. 9, pp. 513–527, 2011. View at Publisher · View at Google Scholar · View at Scopus
  60. J.-C. Farges, J.-F. Keller, F. Carrouel et al., “Odontoblasts in the dental pulp immune response,” Journal of Experimental Zoology Part B: Molecular and Developmental Evolution, vol. 312, no. 5, pp. 425–436, 2009. View at Publisher · View at Google Scholar · View at Scopus
  61. A. Broad, J. A. Kirby, and D. E. J. Jones, “Toll-like receptor interactions: tolerance of MyD88-dependent cytokines but enhancement of MyD88-independent interferon-β production,” Immunology, vol. 120, no. 1, pp. 103–111, 2007. View at Publisher · View at Google Scholar
  62. T. Saito, R. Hirai, Y.-M. Loo et al., “Regulation of innate antiviral defenses through a shared repressor domain in RIG-1 and LGP2,” Proceedings of the National Academy of Sciences of the United States of America, vol. 104, no. 2, pp. 582–587, 2007. View at Publisher · View at Google Scholar · View at Scopus
  63. K. Takeda and S. Akira, “Toll-like receptors in innate immunity,” International Immunology, vol. 17, no. 1, pp. 1–14, 2005. View at Publisher · View at Google Scholar · View at Scopus
  64. U. Buwitt-Beckmann, H. Heine, K.-H. Wiesmüller et al., “TLR1- and TLR6-independent recognition of bacterial lipopeptides,” The Journal of Biological Chemistry, vol. 281, no. 14, pp. 9049–9057, 2006. View at Publisher · View at Google Scholar · View at Scopus
  65. T. Okusawa, M. Fujita, J.-I. Nakamura et al., “Relationship between structures and biological activities of mycoplasmal diacylated lipopeptides and their recognition by toll-like receptors 2 and 6,” Infection and Immunity, vol. 72, no. 3, pp. 1657–1665, 2004. View at Publisher · View at Google Scholar · View at Scopus
  66. D. M. Agnese, J. E. Calvano, S. J. Hahm et al., “Human toll-like receptor 4 mutations but not CD14 polymorphisms are associated with an increased risk of gram-negative infections,” Journal of Infectious Diseases, vol. 186, no. 10, pp. 1522–1525, 2002. View at Publisher · View at Google Scholar · View at Scopus
  67. K. D. Smith and A. Ozinsky, “Toll-like receptor-5 and the innate immune response to bacterial flagellin,” Current Topics in Microbiology and Immunology, vol. 270, pp. 93–108, 2002. View at Google Scholar · View at Scopus
  68. J.-C. Bambou, A. Giraud, S. Menard et al., “In vitro and ex vivo activation of the TLR5 signaling pathway in intestinal epithelial cells by a commensal Escherichia coli strain,” The Journal of Biological Chemistry, vol. 279, no. 41, pp. 42984–42992, 2004. View at Publisher · View at Google Scholar · View at Scopus
  69. M. Jurk, F. Heil, J. Vollmer et al., “Human TLR7 or TLR8 independently confer responsiveness to the antiviral compound R-848,” Nature Immunology, vol. 3, article 499, 2002. View at Publisher · View at Google Scholar · View at Scopus
  70. K. B. Corden, K. S. Gorski, S. J. Gibson et al., “Synthetic TLR agonists reveal functional differences between human TLR7 and TLR8,” The Journal of Immunology, vol. 174, no. 3, pp. 1259–1268, 2005. View at Publisher · View at Google Scholar · View at Scopus
  71. T. B. H. Geijtenbeek and S. I. Gringhuis, “Signalling through C-type lectin receptors: shaping immune responses,” Nature Reviews Immunology, vol. 9, no. 7, pp. 465–479, 2009. View at Publisher · View at Google Scholar · View at Scopus
  72. D. Vijayan, K. J. Radford, A. G. Beckhouse, R. B. Ashman, and C. A. Wells, “Mincle polarizes human monocyte and neutrophil responses to Candida albicans,” Immunology and Cell Biology, vol. 90, no. 9, pp. 889–895, 2012. View at Publisher · View at Google Scholar · View at Scopus
  73. S. E. Girardin, I. G. Boneca, L. A. M. Carneiro et al., “Nod1 detects a unique muropeptide from gram-negative bacterial peptidoglycan,” Science, vol. 300, no. 5625, pp. 1584–1587, 2003. View at Publisher · View at Google Scholar · View at Scopus
  74. N. Inohara, Y. Ogura, A. Fontalba et al., “Host recognition of bacterial muramyl dipeptide mediated through NOD2. implications for Crohn's disease,” The Journal of Biological Chemistry, vol. 278, no. 8, pp. 5509–5512, 2003. View at Publisher · View at Google Scholar · View at Scopus
  75. H. B. Yu and B. B. Finlay, “The caspase-1 inflammasome: a pilot of innate immune responses,” Cell Host and Microbe, vol. 4, no. 3, pp. 198–208, 2008. View at Publisher · View at Google Scholar · View at Scopus
  76. S. Mariathasan, “ASC, Ipaf and Cryopyrin/Nalp3: bona fide intracellular adapters of the caspase-1 inflammasome,” Microbes and Infection, vol. 9, no. 5, pp. 664–671, 2007. View at Publisher · View at Google Scholar · View at Scopus
  77. Y.-M. Loo and M. Gale, “Immune signaling by RIG-I-like receptors,” Immunity, vol. 34, no. 5, pp. 680–692, 2011. View at Publisher · View at Google Scholar · View at Scopus
  78. D. Bamming and C. M. Horvath, “Regulation of signal transduction by enzymatically inactive antiviral RNA helicase proteins MDA5, RIG-I, and LGP2,” The Journal of Biological Chemistry, vol. 284, no. 15, pp. 9700–9712, 2009. View at Publisher · View at Google Scholar · View at Scopus
  79. M.-J. Staquet, S. H. Durand, E. Colomb et al., “Different roles of odontoblasts and fibroblasts in immunity,” Journal of Dental Research, vol. 87, no. 3, pp. 256–261, 2008. View at Publisher · View at Google Scholar · View at Scopus
  80. J.-K. Lee, J. E. Baik, C.-H. Yun et al., “Chlorhexidine gluconate attenuates the ability of lipoteichoic acid from Enterococcus faecalis to stimulate toll-like receptor 2,” Journal of Endodontics, vol. 35, no. 2, pp. 212–215, 2009. View at Publisher · View at Google Scholar · View at Scopus
  81. S. V. Desai, R. M. Love, A. M. Rich, and G. J. Seymour, “Antigen recognition and presentation in periapical tissues: a role for TLR expressing cells?” International Endodontic Journal, vol. 44, no. 2, pp. 87–99, 2011. View at Publisher · View at Google Scholar · View at Scopus
  82. R. P. M. Sutmuller, M. H. M. G. M. den Brok, M. Kramer et al., “Toll-like receptor 2 controls expansion and function of regulatory T cells,” The Journal of Clinical Investigation, vol. 116, no. 2, pp. 485–494, 2006. View at Publisher · View at Google Scholar · View at Scopus
  83. T. Matsuguchi, T. Musikacharoen, T. Ogawa, and Y. Yoshikai, “Gene expressions of Toll-like receptor 2, but not Toll-like receptor 4, is induced by LPS and inflammatory cytokines in mouse macrophages,” The Journal of Immunology, vol. 165, no. 10, pp. 5767–5772, 2000. View at Publisher · View at Google Scholar · View at Scopus
  84. J. Wright and C. E. Bryant, “A new view of innate immunity for the twenty-first century,” in Periodontal Medicine and Systems Biology, Wiley-Blackwell, 2009. View at Google Scholar
  85. A. Uehara and H. Takada, “Functional TLRs and NODs in human gingival fibroblasts,” Journal of Dental Research, vol. 86, no. 3, pp. 249–254, 2007. View at Publisher · View at Google Scholar · View at Scopus
  86. E. Nemoto, T. Honda, S. Kanaya, H. Takada, and H. Shimauchi, “Expression of functional Toll-like receptors and nucleotide-binding oligomerization domain proteins in murine cementoblasts and their upregulation during cell differentiation,” Journal of Periodontal Research, vol. 43, no. 5, pp. 585–593, 2008. View at Publisher · View at Google Scholar · View at Scopus