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Mediators of Inflammation
Volume 2015, Article ID 952536, 9 pages
http://dx.doi.org/10.1155/2015/952536
Review Article

The Emerging and Diverse Roles of Src-Like Adaptor Proteins in Health and Disease

1Department of Genetics, Cell- and Immunobiology, Semmelweis University, 4 Nagyvárad Square, Budapest 1089, Hungary
2MTA-SE “Lendület” Experimental and Translational Immunomics Research Group, 4 Nagyvárad Square, Budapest 1089, Hungary
3Department of Rheumatology, Faculty of Medicine, Semmelweis University, 4 Frankel Leó Street, Budapest 1023, Hungary

Received 28 September 2014; Revised 2 January 2015; Accepted 5 January 2015

Academic Editor: Fulvio D’Acquisto

Copyright © 2015 Nikolett Marton et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Although Src-like adaptor proteins (SLAP-1 and SLAP-2) were mainly studied in lymphocytes, where they act as negative regulators and provide fine control of receptor signaling, recently, several other functions of these proteins were discovered. In addition to the well-characterized immunoregulatory functions, SLAP proteins appear to have an essential role in the pathogenesis of type I hypersensitivity, osteoporosis, and numerous malignant diseases. Both adaptor proteins are expressed in a wide variety of tissues, where they have mostly inhibitory effects on multiple intracellular signaling pathways. In this review, we summarize the diverse effects of SLAP proteins.