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Mediators of Inflammation
Volume 2016, Article ID 1937564, 12 pages
Research Article

T Cell Response in Patients with Implanted Biological and Mechanical Prosthetic Heart Valves

1Federal State Budgetary Institution Research Institute for Complex Issues of Cardiovascular Diseases, Kemerovo 650002, Russia
2Federal State Budgetary Institution Research Institute for Experimental Medicine, Saint Petersburg 197376, Russia
3Far Eastern Federal University, Vladivostok 690091, Russia
4Federal Almazov Medical Research Centre, Saint Petersburg 197341, Russia

Received 21 October 2015; Revised 12 January 2016; Accepted 14 January 2016

Academic Editor: Samuel Huber

Copyright © 2016 L. Barbarash et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The study was aimed at assessing T cell subsets of peripheral blood from recipients of long-term functioning (more than 60 months) biological and mechanical heart valve prostheses. The absolute and relative number of CD4 and CD8 T cell subsets was analyzed: naïve (N, CD45RA+CD62L+), central memory (CM, CD45RACD62L+), effector memory (EM, CD45RACD62L), and terminally differentiated CD45RA-positive effector memory (TEMRA, CD45RA+CD62L) in 25 persons with biological and 7 with mechanical prosthesis compared with 48 apparently healthy volunteers. The relative and absolute number of central memory and naïve CD3+CD8+ in patients with biological prosthesis was decreased (). Meanwhile the number of CD45RA+CD62LCD3+CD8+ and CD3+CD4+ was increased (). Patients with mechanical prosthesis had increased absolute and relative number of CD45RA+CD62LCD3+CD8+ cells (). Also the relative number of CD3+CD4+ cells was reduced (). We assume that altered composition of T cell subsets points at development of xenograft rejection reaction against both mechanical and biological heart valve prostheses.