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Mediators of Inflammation
Volume 2016, Article ID 2853040, 17 pages
http://dx.doi.org/10.1155/2016/2853040
Research Article

GEN-27, a Newly Synthetic Isoflavonoid, Inhibits the Proliferation of Colon Cancer Cells in Inflammation Microenvironment by Suppressing NF-κB Pathway

1State Key Laboratory of Natural Medicines, Department of Physiology, China Pharmaceutical University, Jiangsu, Nanjing 210009, China
2Department of Organic Chemistry, China Pharmaceutical University, Jiangsu, Nanjing 210009, China

Received 1 December 2015; Accepted 14 January 2016

Academic Editor: Munitta Muthana

Copyright © 2016 Yajing Wang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Citations to this Article [3 citations]

The following is the list of published articles that have cited the current article.

  • Yishi Liu, Xiuting Liu, Xin Zhang, Libing Wei, Xiaoping Wang, Lei Tao, Jinrong Lu, Qing Wang, Yang Ding, Rong Hu, and Yuyuan Yao, “Gen-27, a newly synthesized flavonoid, inhibits glycolysis and induces cell apoptosis via suppression of hexokinase II in human breast cancer cells,” Biochemical Pharmacology, vol. 125, pp. 12–25, 2016. View at Publisher · View at Google Scholar
  • Yingxia Ning, Xiaocheng Cao, Meng Xu, Xiangding Chen, and Xin Luo, “Inactivation of AKT, ERK and NF-κB by genistein derivative, 7-difluoromethoxyl-5,4'-di-n-octylygenistein, reduces ovarian carcinoma oncogenicity,” Oncology Reports, vol. 38, no. 2, pp. 949–958, 2017. View at Publisher · View at Google Scholar
  • Yu Zhang, Hou-Wen Chen, Shu-Jin He, Chu-Qi Xiang, Xiang-Tong Lu, and Li-Xia Xiong, “Recent progress on the effects of micrornas and natural products on tumor epithelial-mesenchymal transition,” OncoTargets and Therapy, vol. 10, pp. 3435–3451, 2017. View at Publisher · View at Google Scholar