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Mediators of Inflammation
Volume 2016, Article ID 6131234, 7 pages
http://dx.doi.org/10.1155/2016/6131234
Research Article

Th17 Cell Response in Mice following Motor Nerve Injury

1Oncology Research Institute, Loyola University Chicago, Maywood, IL 60153, USA
2Research Service, Department of Veterans Affairs, Edward Hines, Jr. VA Hospital, Hines, IL 60141, USA
3Department of Brain Disease, Gansu Province Chinese Traditional Medicine Hospital, Lanzhou, Gansu 730050, China
4Department of Ophthalmology, Stritch School of Medicine, Loyola University Chicago, Maywood, IL 60153, USA
5Department of Molecular Virology, Immunology & Medical Genetics, College of Medicine, The Ohio State University, Columbus, OH 43210, USA
6Department of Anatomy and Cell Biology, School of Medicine, Indiana University, Indianapolis, IN 46202, USA
7Research and Development Service, Roudebush VA Hospital, Indianapolis, IN 46202, USA
8Department of Otolaryngology, Loyola University Medical Center, Maywood, IL 60153, USA
9Department of Molecular Pharmacology and Therapeutics, Loyola University Chicago, Maywood, IL 60153, USA

Received 2 December 2015; Accepted 22 February 2016

Academic Editor: Jens Geginat

Copyright © 2016 Allen Ni et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. N. Scarmeas, T. Shih, Y. Stern, R. Ottman, and L. P. Rowland, “Premorbid weight, body mass, and varsity athletics in ALS,” Neurology, vol. 59, no. 5, pp. 773–775, 2002. View at Publisher · View at Google Scholar · View at Scopus
  2. A. Chiò, G. Benzi, M. Dossena, R. Mutani, and G. Mora, “Severely increased risk of amyotrophic lateral sclerosis among Italian professional football players,” Brain, vol. 128, part 3, pp. 472–476, 2005. View at Publisher · View at Google Scholar · View at Scopus
  3. R. D. Horner, K. G. Kamins, J. R. Feussner et al., “Occurrence of amyotrophic lateral sclerosis among Gulf War veterans,” Neurology, vol. 61, no. 6, pp. 742–749, 2003. View at Publisher · View at Google Scholar · View at Scopus
  4. N. A. Mesnard-Hoaglin, J. Xin, M. M. Haulcomb, R. J. Batka, V. M. Sanders, and K. J. Jones, “SOD1G93A transgenic mouse CD4+ T cells mediate neuroprotection after facial nerve axotomy when removed from a suppressive peripheral microenvironment,” Brain, Behavior, and Immunity, vol. 40, pp. 55–60, 2014. View at Publisher · View at Google Scholar
  5. M. Bowerman, T. Vincent, F. Scamps, F. E. Perrin, W. Camu, and C. Raoul, “Neuroimmunity dynamics and the development of therapeutic strategies for amyotrophic lateral sclerosis,” Frontiers in Cellular Neuroscience, vol. 7, article 214, 2013. View at Publisher · View at Google Scholar · View at Scopus
  6. M. C. O. Rodrigues, J. C. Voltarelli, P. R. Sanberg, C. V. Borlongan, and S. Garbuzova-Davis, “Immunological aspects in amyotrophic lateral sclerosis,” Translational Stroke Research, vol. 3, no. 3, pp. 331–340, 2012. View at Publisher · View at Google Scholar · View at Scopus
  7. M. Rentzos, A. Rombos, C. Nikolaou et al., “Interleukin-17 and interleukin-23 are elevated in serum and cerebrospinal fluid of patients with ALS: a reflection of Th17 cells activation?” Acta Neurologica Scandinavica, vol. 122, no. 6, pp. 425–429, 2010. View at Publisher · View at Google Scholar · View at Scopus
  8. M. Fiala, M. Chattopadhay, A. La Cava et al., “IL-17A is increased in the serum and in spinal cord CD8 and mast cells of ALS patients,” Journal of Neuroinflammation, vol. 7, article 76, 2010. View at Publisher · View at Google Scholar · View at Scopus
  9. C. Moreau, D. Devos, V. Brunaud-Danel et al., “Elevated IL-6 and TNF-α levels in patients with ALS: inflammation or hypoxia?” Neurology, vol. 65, no. 12, pp. 1958–1960, 2005. View at Publisher · View at Google Scholar · View at Scopus
  10. J. S. Henkel, D. R. Beers, S. Wen et al., “Regulatory Tlymphocytes mediate amyotrophic lateral sclerosis progression and survival,” EMBO Molecular Medicine, vol. 5, no. 1, pp. 64–79, 2013. View at Publisher · View at Google Scholar
  11. W. Zhao, D. R. Beers, B. Liao, J. S. Henkel, and S. H. Appel, “Regulatory T lymphocytes from ALS mice suppress microglia and effector T lymphocytes through different cytokine-mediated mechanisms,” Neurobiology of Disease, vol. 48, no. 3, pp. 418–428, 2012. View at Publisher · View at Google Scholar · View at Scopus
  12. J. Xin, D. A. Wainwright, C. J. Serpe, V. M. Sanders, and K. J. Jones, “Phenotype of CD4+ T cell subsets that develop following mouse facial nerve axotomy,” Brain, Behavior, and Immunity, vol. 22, no. 4, pp. 528–537, 2008. View at Publisher · View at Google Scholar · View at Scopus
  13. R. Banerjee, R. L. Mosley, A. D. Reynolds et al., “Adaptive immune neuroprotection in G93A-SOD1 amyotrophic lateral sclerosis mice,” PLoS ONE, vol. 3, no. 7, Article ID e2740, 2008. View at Publisher · View at Google Scholar
  14. I. M. Chiu, A. Chen, Y. Zheng et al., “T lymphocytes potentiate endogenous neuroprotective inflammation in a mouse model of ALS,” Proceedings of the National Academy of Sciences of the United States of America, vol. 105, no. 46, pp. 17913–17918, 2008. View at Publisher · View at Google Scholar · View at Scopus
  15. M. S. Maddur, P. Miossec, S. V. Kaveri, and J. Bayry, “Th17 cells: biology, pathogenesis of autoimmune and inflammatory diseases, and therapeutic strategies,” American Journal of Pathology, vol. 181, no. 1, pp. 8–18, 2012. View at Publisher · View at Google Scholar · View at Scopus
  16. J. Xin, D. A. Wainwright, N. A. Mesnard, C. J. Serpe, V. M. Sanders, and K. J. Jones, “IL-10 within the CNS is necessary for CD4+ T cells to mediate neuroprotection,” Brain, Behavior, and Immunity, vol. 25, no. 5, pp. 820–829, 2011. View at Publisher · View at Google Scholar · View at Scopus