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Mediators of Inflammation
Volume 2016, Article ID 7089137, 6 pages
http://dx.doi.org/10.1155/2016/7089137
Research Article

The Th17/Treg Immune Imbalance in Ulcerative Colitis Disease in a Chinese Han Population

1The General Hospital of Shenyang Military Region, Shenyang, Liaoning 110840, China
2Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing 100700, China
3Beijing Wangjing Hospital, Beijing University of Chinese Medicine, Beijing 100102, China
4University of Hawaii Cancer Center, Honolulu, HI 96813, USA

Received 25 September 2015; Revised 24 December 2015; Accepted 5 January 2016

Academic Editor: Kong Chen

Copyright © 2016 Yang Gong et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Objective. To investigate the Th17/Treg immune balance in the ulcerative colitis (UC) patients in a Chinese Han population. Methods. Ninety UC patients and 30 healthy subjects were enrolled. The serum IL-17 and TGF-β1 levels of these participants were measured with ELISA; the percentage of Th17 and Treg cells in peripheral blood was determined with flow cytometry. Results. In UC patients, the levels of IL-17 and Th17 were significantly higher compared with healthy subjects; the percentage of Th17 and IL-17 level in moderate and severe subgroup was significantly higher than in mild subgroup; a positive correlation existed between these two indexes and clinical activity index and endoscopic evaluation. TGF-β1 level and Treg cells in UC patients were lower than healthy subjects. TGF-β1 level in moderate and severe subgroup was lower than in mild subgroup. There was a negative linear correlation between Treg cells and clinical activity index, endoscopic evaluation. A positive correlation was detected between Treg cells and TGF-β1 level. Conclusions. Th17/Treg immune imbalance might play a crucial role in the development of UC. To induce the production of Treg cells and TGF-β1, inhibit the level of Th17 and IL-17, and thus recover the Th17/Treg immune balance might imply new therapeutic targets in UC management.