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Mediators of Inflammation
Volume 2016, Article ID 7617954, 7 pages
Research Article

Extra-Articular Symptoms in Constellation with Selected Serum Cytokines and Disease Activity in Spondyloarthritis

1Department of Rheumatology, Internal Medicine and Geriatrics, Pomeranian Medical University in Szczecin, Unii Lubelskiej 1, 71-252 Szczecin, Poland
2Independent Laboratory of Rheumatic Diagnostics, Pomeranian Medical University in Szczecin, Unii Lubelskiej 1, 71-252 Szczecin, Poland

Received 30 September 2016; Accepted 17 November 2016

Academic Editor: Yu Sun

Copyright © 2016 Hanna Przepiera-Będzak et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Objectives. In this study, we assessed the extra-articular symptoms in constellation with selected serum cytokines and disease activity in spondyloarthritis (SpA). Patients and Methods. We studied 287 SpA patients: 131 had AS, 110 had PsA, and 46 had SAPHO. We assessed extra-articular symptoms in all cases. In 191 SpA patients, we measured serum interleukin-6 (IL-6), interleukin-18 (IL-18), interleukin-23 (IL-23), endothelin-1 (ET-1), vascular endothelial growth factor (VEGF), and epidermal growth factor (EGF). Results. Patients with acute anterior uveitis (AAU) had higher VAS (), BADSDAI (), ASDAS-ESR (), CRP (), IL-6 (), and IL-18 () levels. Patients with inflammatory bowel disease (IBD) had higher VAS (), CRP (), and IL-6 () levels. Patients with skin psoriasis had lower VAS () and BASDAI () levels. Patients with psoriatic onycholysis had lower VAS (), BASDAI (), and CRP () and higher IL-23 () levels. Patients with PPP had lower BASDAI () and higher ET-1 () levels. Conclusions. SpA patients with increased serum IL-18 and decreased serum ET-1 had an increased risk of extra-articular symptoms. In SpA patients, increased disease activity was associated with an increased risk of AAU and IBD and a decreased risk of skin psoriasis, psoriatic onycholysis, and PPP.