Melatonin Attenuates Contrast-Induced Nephropathy in Diabetic Rats: The Role of Interleukin-33 and Oxidative Stress

Figure 2

Electron microscopy findings of renal tissue samples of groups (×10000). Normal pedicels (white arrow) in the periendothelial area of renal tissue of HRs (Figure 2(a)). Closure of the filtration slits with atypic pedicels in the periendothelial area and electron-dense endothelial cytoplasm of CIN + DRs (Figure 2(b)). Basement membranes and pedicels of glomerulus of MTDRs (Figure 2(c)) and MTCIN + DRs (Figure 2(d)). P: podocyte; Ec: endothelial cell; MC: mesangial cell; MTDRs: melatonin-treated diabetic rats; MTCIN + DRs: melatonin-treated diabetic rats with contrast-induced nephropathy; DRs: diabetic rats; HRs: healthy rats; CIN + DRs: diabetic rats with contrast-induced nephropathy.

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