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Mediators of Inflammation
Volume 2017, Article ID 3102737, 11 pages
Review Article

Cigarette Smoking and Adipose Tissue: The Emerging Role in Progression of Atherosclerosis

Department of Cardiology, Shanghai General Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200080, China

Correspondence should be addressed to Yi Wang; moc.liamtoh@cilbupiygnaw

Received 9 June 2017; Revised 8 November 2017; Accepted 27 November 2017; Published 27 December 2017

Academic Editor: Arbi Pecani

Copyright © 2017 Zhiyan Wang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Smoking is an established risk factor for atherosclerosis through several underlying pathways. Moreover, in the development of atherosclerotic plaque formation, obesity, defined as excess fat mass accumulation, also plays a vital role in dyslipidemia and insulin resistance. Substantial evidence shows that cigarette smoking induces multiple pathological effects in adipose tissue, such as differentiation of adipocytes, lipolysis, and secretion properties in adipose tissue. Therefore, there is an emerging speculation in which adipose tissue abnormality induced by smoking or nicotine is likely to accelerate the progression of atherosclerosis. Herein, this review aims to investigate the possible interplay between smoking and adipose tissue dysfunction in the development of atherosclerosis.