A corrigendum for this article has been published. To view the corrigendum, please click here.
Mediators of Inflammation
Volume 2017, Article ID 3824276, 9 pages
https://doi.org/10.1155/2017/3824276
Overexpression of Cholesteryl Ester Transfer Protein Increases Macrophage-Derived Foam Cell Accumulation in Atherosclerotic Lesions of Transgenic Rabbits
1Research Institute of Atherosclerotic Disease, Xi’an Jiaotong University Cardiovascular Research Center, Xi’an, Shaanxi 710061, China
2Laboratory Animal Center, Xi’an Jiaotong University Health Science Center, Xi’an, Shaanxi 710061, China
3Laboratory Animal Center, Ningxia Medical University, Ningxia 750004, China
4Department of Molecular Pathology, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, Yamanashi 409-3898, Japan
Correspondence should be addressed to Enqi Liu; nc.ude.utjx.liam@iqneuil
Received 27 May 2017; Revised 13 October 2017; Accepted 2 November 2017; Published 28 November 2017
Academic Editor: Fabio Cacciapaglia
Copyright © 2017 Shoucui Gao et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Linked References
- I. M. Singh, M. H. Shishehbor, and B. J. Ansell, “High-density lipoprotein as a therapeutic target: a systematic review,” JAMA, vol. 298, no. 7, pp. 786–798, 2007. View at Publisher · View at Google Scholar · View at Scopus
- P. J. Barter, “Hugh Sinclair lecture: the regulation and remodelling of HDL by plasma factors,” Atherosclerosis. Supplements, vol. 3, no. 4, pp. 39–47, 2002. View at Publisher · View at Google Scholar · View at Scopus
- J. J. Kastelein, S. I. van Leuven, L. Burgess et al., “Effect of torcetrapib on carotid atherosclerosis in familial hypercholesterolemia,” The New England Journal of Medicine, vol. 356, no. 16, pp. 1620–1630, 2007. View at Publisher · View at Google Scholar · View at Scopus
- G. G. Schwartz, A. G. Olsson, M. Abt et al., “Effects of dalcetrapib in patients with a recent acute coronary syndrome,” The New England Journal of Medicine, vol. 367, no. 22, pp. 2089–2099, 2012. View at Publisher · View at Google Scholar · View at Scopus
- A. Sahebkar, L. E. Simental-Mendía, F. Guerrero-Romero, J. Golledge, and G. F. Watts, “Efficacy and safety of evacetrapib for modifying plasma lipids: a systematic review and meta-analysis of randomized controlled trials,” Current Pharmaceutical Design, vol. 22, no. 5, pp. 595–608, 2016. View at Publisher · View at Google Scholar
- V. A. Eyvazian and W. H. Frishman, “Evacetrapib: another CETP inhibitor for dyslipidemia with no clinical benefit,” Cardiology in Review, vol. 25, no. 2, pp. 43–52, 2017. View at Publisher · View at Google Scholar
- J. H. McLain, A. J. Alsterda, and R. R. Arora, “Cholesteryl ester transfer protein inhibitors: trials and tribulations,” Journal of Cardiovascular Pharmacology and Therapeutics, 2016. View at Publisher · View at Google Scholar
- T. D. Filippatos, E. Klouras, F. Barkas, and M. Elisaf, “Cholesteryl ester transfer protein inhibitors: challenges and perspectives,” Expert Review of Cardiovascular Therapy, vol. 14, no. 8, pp. 953–962, 2016. View at Publisher · View at Google Scholar · View at Scopus
- S. Bernard, P. Moulin, L. Lagrost et al., “Association between plasma HDL-cholesterol concentration and Taq1B CETP gene polymorphism in non-insulin-dependent diabetes mellitus,” Journal of Lipid Research, vol. 39, no. 1, pp. 59–65, 1998. View at Google Scholar
- M. E. Brousseau, J. J. O’connor, J. M. Ordovas et al., “Cholesteryl ester transfer protein TaqI B2B2 genotype is associated with higher HDL cholesterol levels and lower risk of coronary heart disease end points in men with HDL deficiency: veterans affairs HDL cholesterol intervention trial,” Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 22, no. 7, pp. 1148–1154, 2002. View at Publisher · View at Google Scholar · View at Scopus
- D. J. Freeman, B. A. Griffin, A. P. Holmes et al., “Regulation of plasma HDL cholesterol and subfraction distribution by genetic and environmental factors. Associations between the TaqI B RFLP in the CETP gene and smoking and obesity,” Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 14, no. 3, pp. 336–344, 1994. View at Publisher · View at Google Scholar
- J. A. Kuivenhoven, P. de Knijff, J. M. A. Boer et al., “Heterogeneity at the CETP gene locus. Influence on plasma CETP concentrations and HDL cholesterol levels,” Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 17, no. 3, pp. 560–568, 1997. View at Publisher · View at Google Scholar
- S. Liu, C. Schmitz, M. J. Stampfer et al., “A prospective study of TaqIB polymorphism in the gene coding for cholesteryl ester transfer protein and risk of myocardial infarction in middle-aged men,” Atherosclerosis, vol. 161, no. 2, pp. 469–474, 2002. View at Publisher · View at Google Scholar · View at Scopus
- L. Masucci-Magoulas, A. Plump, X. C. Jiang, A. Walsh, J. L. Breslow, and A. R. Tall, “Profound induction of hepatic cholesteryl ester transfer protein transgene expression in apolipoprotein E and low density lipoprotein receptor gene knockout mice. A novel mechanism signals changes in plasma cholesterol levels,” The Journal of Clinical Investigation, vol. 97, no. 1, pp. 154–161, 1996. View at Publisher · View at Google Scholar
- M. El Bouhassani, S. Gilibert, M. Moreau et al., “Cholesteryl ester transfer protein expression partially attenuates the adverse effects of SR-BI receptor deficiency on cholesterol metabolism and atherosclerosis,” The Journal of Biological Chemistry, vol. 286, no. 19, pp. 17227–17238, 2011. View at Publisher · View at Google Scholar · View at Scopus
- M. J. Chapman, W. le Goff, M. Guerin, and A. Kontush, “Cholesteryl ester transfer protein: at the heart of the action of lipid-modulating therapy with statins, fibrates, niacin, and cholesteryl ester transfer protein inhibitors,” European Heart Journal, vol. 31, no. 2, pp. 149–164, 2010. View at Publisher · View at Google Scholar · View at Scopus
- K. R. Marotti, C. K. Castle, R. W. Murray, E. F. Rehberg, H. G. Polites, and G. W. Melchior, “The role of cholesteryl ester transfer protein in primate apolipoprotein A-I metabolism. Insights from studies with transgenic mice,” Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 12, no. 6, pp. 736–744, 1992. View at Publisher · View at Google Scholar
- B. Foger, M. Chase, M. J. Amar et al., “Cholesteryl ester transfer protein corrects dysfunctional high density lipoproteins and reduces aortic atherosclerosis in lecithin cholesterol acyltransferase transgenic mice,” The Journal of Biological Chemistry, vol. 274, no. 52, pp. 36912–36920, 1999. View at Publisher · View at Google Scholar · View at Scopus
- J. Fan, S. Kitajima, T. Watanabe et al., “Rabbit models for the study of human atherosclerosis: from pathophysiological mechanisms to translational medicine,” Pharmacology & Therapeutics, vol. 146, pp. 104–119, 2015. View at Publisher · View at Google Scholar · View at Scopus
- H. Okamoto, F. Yonemori, K. Wakitani, T. Minowa, K. Maeda, and H. Shinkai, “A cholesteryl ester transfer protein inhibitor attenuates atherosclerosis in rabbits,” Nature, vol. 406, no. 6792, pp. 203–207, 2000. View at Publisher · View at Google Scholar · View at Scopus
- C. W. Rittershaus, D. P. Miller, L. J. Thomas et al., “Vaccine-induced antibodies inhibit CETP activity in vivo and reduce aortic lesions in a rabbit model of atherosclerosis,” Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 20, no. 9, pp. 2106–2112, 2000. View at Publisher · View at Google Scholar
- Z. Huang, A. Inazu, A. Nohara, T. Higashikata, and H. Mabuchi, “Cholesteryl ester transfer protein inhibitor (JTT-705) and the development of atherosclerosis in rabbits with severe hypercholesterolaemia,” Clinical Science, vol. 103, no. 6, pp. 587–594, 2002. View at Publisher · View at Google Scholar
- M. Sugano, N. Makino, S. Sawada et al., “Effect of antisense oligonucleotides against cholesteryl ester transfer protein on the development of atherosclerosis in cholesterol-fed rabbits,” The Journal of Biological Chemistry, vol. 273, no. 9, pp. 5033–5036, 1998. View at Publisher · View at Google Scholar · View at Scopus
- S. Zhao, Y. Li, S. Gao et al., “Autocrine human urotensin II enhances macrophage-derived foam cell formation in transgenic rabbits,” BioMed Research International, vol. 2015, Article ID 843959, 8 pages, 2015. View at Publisher · View at Google Scholar
- S. Kuhnast, M. C. Louwe, M. M. Heemskerk et al., “Niacin reduces atherosclerosis development in apoE3leiden.CETP mice mainly by reducing nonHDL-cholesterol,” PLoS One, vol. 8, no. 6, article e66467, 2013. View at Publisher · View at Google Scholar · View at Scopus
- S. Zhao, C. Zhang, Y. Lin et al., “The effects of rosiglitazone on aortic atherosclerosis of cholesterol-fed rabbits,” Thrombosis Research, vol. 123, no. 2, pp. 281–287, 2008. View at Publisher · View at Google Scholar · View at Scopus
- C. Zhang, H. Zheng, Q. Yu et al., “A practical method for quantifying atherosclerotic lesions in rabbits,” Journal of Comparative Pathology, vol. 142, no. 2-3, pp. 122–128, 2010. View at Publisher · View at Google Scholar · View at Scopus
- J. Liang, E. Liu, Y. Yu et al., “Macrophage metalloelastase accelerates the progression of atherosclerosis in transgenic rabbits,” Circulation, vol. 113, no. 16, pp. 1993–2001, 2006. View at Publisher · View at Google Scholar · View at Scopus
- M. L. Brown, A. Inazu, C. B. Hesler et al., “Molecular basis of lipid transfer protein deficiency in a family with increased high-density lipoproteins,” Nature, vol. 342, no. 6248, pp. 448–451, 1989. View at Publisher · View at Google Scholar
- K. R. Marotti, C. K. Castle, T. P. Boyle, A. H. Lin, R. W. Murray, and G. W. Melchior, “Severe atherosclerosis in transgenic mice expressing simian cholesteryl ester transfer protein,” Nature, vol. 364, no. 6432, pp. 73–75, 1993. View at Publisher · View at Google Scholar
- D. Bhatnagar, P. N. Durrington, K. M. Channon, H. Prais, and M. I. Mackness, “Increased transfer of cholesteryl esters from high density lipoproteins to low density and very low density lipoproteins in patients with angiographic evidence of coronary artery disease,” Atherosclerosis, vol. 98, no. 1, pp. 25–32, 1993. View at Publisher · View at Google Scholar · View at Scopus
- V. L. Herrera, S. C. Makrides, H. X. Xie et al., “Spontaneous combined hyperlipidemia, coronary heart disease and decreased survival in Dahl salt-sensitive hypertensive rats transgenic for human cholesteryl ester transfer protein,” Nature Medicine, vol. 5, no. 12, pp. 1383–1389, 1999. View at Publisher · View at Google Scholar · View at Scopus
- T. Hayek, L. Masucci-Magoulas, X. Jiang et al., “Decreased early atherosclerotic lesions in hypertriglyceridemic mice expressing cholesteryl ester transfer protein transgene,” The Journal of Clinical Investigation, vol. 96, no. 4, pp. 2071–2074, 1995. View at Publisher · View at Google Scholar
- S. Zhong, D. S. Sharp, J. S. Grove et al., “Increased coronary heart disease in Japanese-American men with mutation in the cholesteryl ester transfer protein gene despite increased HDL levels,” The Journal of Clinical Investigation, vol. 97, no. 12, pp. 2917–2923, 1996. View at Publisher · View at Google Scholar
- J. Zhang, J. Xu, J. Liang et al., “CETP deficiency in rabbits protects high fat high cholesterol diet induced atherosclerosis,” Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 35, pp. 1068–1075, 2015. View at Google Scholar
- I. Tabas and A. H. Lichtman, “Monocyte-macrophages and T cells in atherosclerosis,” Immunity, vol. 47, no. 4, pp. 621–634, 2017. View at Publisher · View at Google Scholar
- S. K. Mohanta, C. Yin, L. Peng et al., “Artery tertiary lymphoid organs contribute to innate and adaptive immune responses in advanced mouse atherosclerosis,” Circulation Research, vol. 114, no. 11, pp. 1772–1787, 2014. View at Publisher · View at Google Scholar · View at Scopus
- R. A. Iseme, M. McEvoy, B. Kelly et al., “A role for autoantibodies in atherogenesis,” Cardiovascular Research, vol. 113, no. 10, pp. 1102–1112, 2017. View at Publisher · View at Google Scholar
- W. Le Goff, M. Guerin, and M. J. Chapman, “Pharmacological modulation of cholesteryl ester transfer protein, a new therapeutic target in atherogenic dyslipidemia,” Pharmacology & Therapeutics, vol. 101, no. 1, pp. 17–38, 2004. View at Publisher · View at Google Scholar · View at Scopus
- B. Foger, A. Ritsch, A. Doblinger, H. Wessels, and J. R. Patsch, “Relationship of plasma cholesteryl ester transfer protein to HDL cholesterol. Studies in normotriglyceridemia and moderate hypertriglyceridemia,” Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 16, no. 12, pp. 1430–1436, 1996. View at Publisher · View at Google Scholar
- P. Linsel-Nitschke and A. R. Tall, “HDL as a target in the treatment of atherosclerotic cardiovascular disease,” Nature Reviews. Drug Discovery, vol. 4, no. 3, pp. 193–205, 2005. View at Publisher · View at Google Scholar · View at Scopus
- A. R. Tall and N. Wang, “Tangier disease as a test of the reverse cholesterol transport hypothesis,” The Journal of Clinical Investigation, vol. 106, no. 10, pp. 1205–1207, 2000. View at Publisher · View at Google Scholar
- F. Matsuura, N. Wang, W. Chen, X. C. Jiang, and A. R. Tall, “HDL from CETP-deficient subjects shows enhanced ability to promote cholesterol efflux from macrophages in an apoE- and ABCG1-dependent pathway,” The Journal of Clinical Investigation, vol. 116, no. 5, pp. 1435–1442, 2006. View at Publisher · View at Google Scholar · View at Scopus
- L. Yvan-Charvet, F. Matsuura, N. Wang et al., “Inhibition of cholesteryl ester transfer protein by torcetrapib modestly increases macrophage cholesterol efflux to HDL,” Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 27, no. 5, pp. 1132–1138, 2007. View at Publisher · View at Google Scholar · View at Scopus