The Metabolic Syndrome, Inflammation, and Colorectal Cancer Risk: An Evaluation of Large Panels of Plasma Protein Markers Using Repeated, Prediagnostic Samples
Table 1
(a) Characteristics of study participants, stratified by sampling occasion. (b) Characteristics of study participants, stratified by colorectal cancer (CRC) status at the second sampling occasion.
(a)
Characteristics
Sample 1 (a)
Sample 2 (a)
b
Median (range)
Median (range)
Age
49.9 (30.0–52.4)
59.9 (40.0–60.5)
—
Height
173 (157–195)
172 (155–196)
<0.001
Weight
76.5 (51–128)
80.0 (51–139)
<0.001
Triglycerides, mmol/l
1.0 (0.4-5.2)
1.1 (0.5–3.8)
0.98
Total cholesterol, mmol/l
5.5 (3.5–9.5)
5.5 (3.4–10.1)
0.18
Diastolic bp
79.0 (60.0–120.0)
80.0 (60.0–110.0)
0.12
Systolic bp
120.0 (94.0–180.0)
126.0 (90.0–179.0)
0.04
Fasting plasma glucose, mmol/l
5.4 (4.0–6.9)
5.5 (1.0–13.1)
0.003
BMI
25.3 (18.8–41.3)
26.0 (18.4–44.9)
<0.001
Categorized BMI (N, (%))
—
—
0.08
<18.5 (underweight)
0
1 (1)
—
18.5–24.9 (normal)
62 (45)
52 (38)
—
25–29.9 (overweight)
60 (43)
56 (41)
—
30+ (obese)
16 (16)
29 (21)
—
MetS (yes, %)
12 (9)
24 (17)
0.05
aNumber of samples. bPaired t-tests for differences in continuous variables between measurements 1 and 2. Chi-square test or Fisher’s exact test (if expected cell count is below 5) for differences in categorical variables.
(b)
Characteristics
Case ()
Control ()
b
Median (range)
Median (range)
Age (at sampling occasion)
59.9 (40.3–60.4)
59.9 (40.0–60.5)
—
Height
172.5 (156–196)
172 (155–191)
0.99
Weight
81.0 (56–114)
78.0 (51–139)
0.95
Triglycerides, mmol/l
1.1 (0.6–3.5)
1.1 (0.5–3.8)
0.99
Total cholesterol, mmol/l
5.4 (3.8–7.6)
5.6 (3.4–10.1)
0.03
Diastolic bp
82.0 (62.0–105.0)
80.0 (60.0–110.0)
0.14
Systolic bp
126.0 (90.0–163.0)
126.0 (90.0–179.0)
0.80
Fasting plasma glucose, mmol/l
5.7 (1.0–11.1)
5.5 (4.1–13.1)
0.73
BMI
26.1 (21.0–36.0)
26.0 (18.4–44.9)
0.82
Categorized BMI (N, (%))
—
—
0.12
<18.5 (underweight)
0
1 (1)
—
18.5–24.9 (normal)
22 (32)
30 (43)
—
25–29.9 (overweight)
34 (50)
22 (32)
—
30+ (obese)
12 (18)
16 (23)
—
MetS score
−0.02 (−0.60–0.54)
−0.06 (−0.80–0.51)
0.26
MetS (yes, %)
9 (13)
15 (22)
—
All data refer to characteristics at the second sampling as depicted in Table 1(a). bPaired t-tests for differences in continuous variables between matched cases and controls. Chi-square test or Fisher’s exact test (if expected cell count is below 5) for differences in categorical variables.
