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Mediators of Inflammation
Volume 2017, Article ID 5187368, 10 pages
https://doi.org/10.1155/2017/5187368
Research Article

Nuclear Translocation of SGPP-1 and Decrease of SGPL-1 Activity Contribute to Sphingolipid Rheostat Regulation of Inflammatory Dendritic Cells

1Institute of General Pharmacology and Toxicology, pharmazentrum frankfurt/ZAFES, Hospital of the Goethe University, Frankfurt, Germany
2Institute of Clinical Pharmacology, pharmazentrum frankfurt, Hospital of the Goethe University, Frankfurt, Germany
3Institute of Nutritional Science, University of Potsdam, Potsdam, Germany

Correspondence should be addressed to Anja Schwiebs; ed.trufknarf-inu.dem@sbeiwhcs

Received 2 June 2017; Revised 22 August 2017; Accepted 3 October 2017; Published 11 December 2017

Academic Editor: Alice Alessenko

Copyright © 2017 Anja Schwiebs et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. O. Arlt, A. Schwiebs, L. Japtok et al., “Sphingosine-1-phosphate modulates dendritic cell function: focus on non-migratory effects in vitro and in vivo,” Cellular Physiology and Biochemistry, vol. 34, no. 1, pp. 27–44, 2014. View at Publisher · View at Google Scholar · View at Scopus
  2. A. Schwiebs, O. Friesen, E. Katzy, N. Ferreirós, J. M. Pfeilschifter, and H. H. Radeke, “Activation-induced cell death of dendritic cells is dependent on sphingosine kinase 1,” Frontiers in Pharmacology, vol. 7, p. 94, 2016. View at Publisher · View at Google Scholar · View at Scopus
  3. M. Schroder, C. Richter, M. H. Juan et al., “The sphingosine kinase 1 and S1P1 axis specifically counteracts LPS-induced IL-12p70 production in immune cells of the spleen,” Molecular Immunology, vol. 48, no. 9-10, pp. 1139–1148, 2011. View at Publisher · View at Google Scholar · View at Scopus
  4. L. Japtok, K. Schaper, W. Bäumer, H. H. Radeke, S. K. Jeong, and B. Kleuser, “Sphingosine 1-phosphate modulates antigen capture by murine Langerhans cells via the S1P2 receptor subtype,” PLoS One, vol. 7, no. 11, article e49427, 2012. View at Publisher · View at Google Scholar · View at Scopus
  5. A. Martino, E. Volpe, G. Auricchio et al., “Sphingosine 1-phosphate interferes on the differentiation of human monocytes into competent dendritic cells,” Scandinavian Journal of Immunology, vol. 65, no. 1, pp. 84–91, 2007. View at Publisher · View at Google Scholar · View at Scopus
  6. A. Renkl, L. Berod, M. Mockenhaupt et al., “Distinct effects of sphingosine-1-phosphate, lysophosphatidic acid and histamine in human and mouse dendritic cells,” International Journal of Molecular Medicine, vol. 13, no. 2, pp. 203–209, 2004. View at Google Scholar
  7. P. P. van Veldhoven and G. P. Mannaerts, “Sphingosine-phosphate lyase,” Advances in Lipid Research, vol. 26, pp. 69–98, 1993. View at Google Scholar
  8. C. Ogawa, A. Kihara, M. Gokoh, and Y. Igarashi, “Identification and characterization of a novel human sphingosine-1-phosphate phosphohydrolase, hSPP2,” The Journal of Biological Chemistry, vol. 278, no. 2, pp. 1268–1272, 2003. View at Publisher · View at Google Scholar · View at Scopus
  9. S. M. Mandala, R. Thornton, Z. Tu et al., “Sphingoid base 1-phosphate phosphatase: a key regulator of sphingolipid metabolism and stress response,” Proceedings of the National Academy of Sciences of the United States of America, vol. 95, no. 1, pp. 150–155, 1998. View at Publisher · View at Google Scholar · View at Scopus
  10. S. M. Mandala, R. Thornton, I. Galve-Roperh et al., “Molecular cloning and characterization of a lipid phosphohydrolase that degrades sphingosine-1- phosphate and induces cell death,” Proceedings of the National Academy of Sciences of the United States of America, vol. 97, no. 14, pp. 7859–7864, 2000. View at Publisher · View at Google Scholar · View at Scopus
  11. H. Le Stunff, C. Peterson, R. Thornton, S. Milstien, S. M. Mandala, and S. Spiegel, “Characterization of murine sphingosine-1-phosphate phosphohydrolase,” The Journal of Biological Chemistry, vol. 277, no. 11, pp. 8920–8927, 2002. View at Publisher · View at Google Scholar · View at Scopus
  12. K. R. Johnson, K. Y. Johnson, K. P. Becker, J. Bielawski, C. Mao, and L. M. Obeid, “Role of human sphingosine-1-phosphate phosphatase 1 in the regulation of intra- and extracellular sphingosine-1-phosphate levels and cell viability,” The Journal of Biological Chemistry, vol. 278, no. 36, pp. 34541–34547, 2003. View at Publisher · View at Google Scholar · View at Scopus
  13. X. Y. Gao, L. Li, X. H. Wang et al., “Inhibition of sphingosine-1-phosphate phosphatase 1 promotes cancer cells migration in gastric cancer: clinical implications,” Oncology Reports, vol. 34, no. 4, pp. 1977–1987, 2015. View at Publisher · View at Google Scholar · View at Scopus
  14. S. Lepine, J. C. Allegood, M. Park, P. Dent, S. Milstien, and S. Spiegel, “Sphingosine-1-phosphate phosphohydrolase-1 regulates ER stress-induced autophagy,” Cell Death and Differentiation, vol. 18, no. 2, pp. 350–361, 2011. View at Publisher · View at Google Scholar · View at Scopus
  15. M. L. Allende, L. M. Sipe, G. Tuymetova, K. L. Wilson-Henjum, W. Chen, and R. L. Proia, “Sphingosine-1-phosphate phosphatase 1 regulates keratinocyte differentiation and epidermal homeostasis,” The Journal of Biological Chemistry, vol. 288, no. 25, pp. 18381–18391, 2013. View at Publisher · View at Google Scholar · View at Scopus
  16. S. Nair, G. E. Archer, and T. F. Tedder, “Isolation and generation of human dendritic cells,” Current Protocols in Immunology, vol. 32, 2012. View at Publisher · View at Google Scholar
  17. G. Grammatikos, N. Ferreiròs, O. Waidmann et al., “Serum sphingolipid variations associate with hepatic decompensation and survival in patients with cirrhosis,” PLoS One, vol. 10, no. 9, article e0138130, 2015. View at Publisher · View at Google Scholar · View at Scopus
  18. A. Luth, C. Neuber, and B. Kleuser, “Novel methods for the quantification of (2E)-hexadecenal by liquid chromatography with detection by either ESI QTOF tandem mass spectrometry or fluorescence measurement,” Analytica Chimica Acta, vol. 722, pp. 70–79, 2012. View at Publisher · View at Google Scholar · View at Scopus
  19. A. Kawahara, T. Nishi, Y. Hisano, H. Fukui, A. Yamaguchi, and N. Mochizuki, “The sphingolipid transporter spns2 functions in migration of zebrafish myocardial precursors,” Science, vol. 323, no. 5913, pp. 524–527, 2009. View at Publisher · View at Google Scholar · View at Scopus
  20. C. Dillmann, C. Ringel, J. Ringleb et al., “S1PR4 signaling attenuates ILT 7 internalization to limit IFN-α production by human plasmacytoid dendritic cells,” Journal of Immunology, vol. 196, no. 4, pp. 1579–1590, 2016. View at Publisher · View at Google Scholar · View at Scopus
  21. K. Schaper, M. Kietzmann, and W. Baumer, “Sphingosine-1-phosphate differently regulates the cytokine production of IL-12, IL-23 and IL-27 in activated murine bone marrow derived dendritic cells,” Molecular Immunology, vol. 59, no. 1, pp. 10–18, 2014. View at Publisher · View at Google Scholar · View at Scopus
  22. H. Le Stunff, I. Galve-Roperh, C. Peterson, S. Milstien, and S. Spiegel, “Sphingosine-1-phosphate phosphohydrolase in regulation of sphingolipid metabolism and apoptosis,” The Journal of Cell Biology, vol. 158, no. 6, pp. 1039–1049, 2002. View at Publisher · View at Google Scholar · View at Scopus
  23. P. Giussani, M. Maceyka, H. le Stunff et al., “Sphingosine-1-phosphate phosphohydrolase regulates endoplasmic reticulum-to-golgi trafficking of ceramide,” Molecular and Cellular Biology, vol. 26, no. 13, pp. 5055–5069, 2006. View at Publisher · View at Google Scholar · View at Scopus
  24. N. Kobayashi, T. Nishi, T. Hirata et al., “Sphingosine 1-phosphate is released from the cytosol of rat platelets in a carrier-mediated manner,” Journal of Lipid Research, vol. 47, no. 3, pp. 614–621, 2006. View at Publisher · View at Google Scholar · View at Scopus
  25. N. Kobayashi, N. Kobayashi, A. Yamaguchi, and T. Nishi, “Characterization of the ATP-dependent sphingosine 1-phosphate transporter in rat erythrocytes,” The Journal of Biological Chemistry, vol. 284, no. 32, pp. 21192–21200, 2009. View at Publisher · View at Google Scholar · View at Scopus
  26. T. Nishi, N. Kobayashi, Y. Hisano, A. Kawahara, and A. Yamaguchi, “Molecular and physiological functions of sphingosine 1-phosphate transporters,” Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, vol. 1841, no. 5, pp. 759–765, 2014. View at Publisher · View at Google Scholar · View at Scopus
  27. P. Mitra, C. A. Oskeritzian, S. G. Payne, M. A. Beaven, S. Milstien, and S. Spiegel, “Role of ABCC1 in export of sphingosine-1-phosphate from mast cells,” Proceedings of the National Academy of Sciences of the United States of America, vol. 103, no. 44, pp. 16394–16399, 2006. View at Publisher · View at Google Scholar · View at Scopus
  28. K. Takabe, R. H. Kim, J. C. Allegood et al., “Estradiol induces export of sphingosine 1-phosphate from breast cancer cells via ABCC1 and ABCG2,” The Journal of Biological Chemistry, vol. 285, no. 14, pp. 10477–10486, 2010. View at Publisher · View at Google Scholar · View at Scopus
  29. K. Ihlefeld, H. Vienken, R. F. Claas et al., “Upregulation of ABC transporters contributes to chemoresistance of sphingosine 1-phosphate lyase-deficient fibroblasts,” Journal of Lipid Research, vol. 56, no. 1, pp. 60–69, 2015. View at Google Scholar
  30. Y. Hisano, N. Kobayashi, A. Yamaguchi, and T. Nishi, “Mouse SPNS2 functions as a sphingosine-1-phosphate transporter in vascular endothelial cells,” PLoS One, vol. 7, no. 6, article e38941, 2012. View at Publisher · View at Google Scholar · View at Scopus
  31. S. Fukuhara, S. Simmons, S. Kawamura et al., “The sphingosine-1-phosphate transporter Spns2 expressed on endothelial cells regulates lymphocyte trafficking in mice,” The Journal of Clinical Investigation, vol. 122, no. 4, pp. 1416–1426, 2012. View at Publisher · View at Google Scholar · View at Scopus