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Mediators of Inflammation
Volume 2017 (2017), Article ID 5650627, 10 pages
Clinical Study

Evidences of a New Psychobiotic Formulation on Body Composition and Anxiety

1CNR, IBFM UOS of Germaneto, University “Magna Graecia” of Catanzaro, Campus “Salvatore Venuta”, Germaneto, 88100 Catanzaro, Italy
2Comparative Neuroanatomy Laboratory of Ecology Department, University of Calabria, Ponte Pietro Bucci, Arcavacata di Rende, 87030 Cosenza, Italy
3Department of Systems Medicine, University of Rome Tor Vergata, Via Montpellier 1, 00133 Rome, Italy
4PhD School of Medical-Surgical Applied Sciences, University of Rome Tor Vergata, Via Montpellier 1, 00133 Rome, Italy
5CAPES Scholarship (Proc No. BEX 13264/13-3), CAPES Foundation, Ministry of Education of Brazil, 70040-020 Brasília, DF, Brazil
6Health Center Srl, Biomedical and Nutritional Center, 87100 Cosenza, Italy
7Section of Clinical Nutrition and Nutrigenomic, Department of Biomedicine and Prevention, University of Rome Tor Vergata, Via Montpellier 1, 00133 Rome, Italy

Correspondence should be addressed to Laura Di Renzo;

Received 1 June 2017; Accepted 3 August 2017; Published 24 September 2017

Academic Editor: Giovanni Gambassi

Copyright © 2017 Carmela Colica et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Background. Gut microbiota is implied in obesity, because of its ability to harvest energy from diet, and in the regulation of behavior. Given the link between gut microbiota, body composition, obesity, and anxiety, the aim of this study was to evaluate the effects of a new psychobiotic formulation. Methods. Eligible patients were randomly divided into three groups: psychobiotics oral suspension group (POSG); dietary treatment group (DTG); combined treatment group (CTG). All subjects underwent body composition and psychological profile evaluation. Results. Significant changes in body composition parameters in each group were relieved after all treatments. Hamilton anxiety rating scale (HAM-A) highlighted a significant reduction of the total score for all study population after treatments in POSG () and CTG (). A reduction of HAM-A total score in anxious subjects in POSG or CTG and a significant reduction of positive subjects for HAM-A in POSG () and in CDG () were shown. Discussion. Three-week intake of selected POS represents a good approach to solve problems related to obesity and behavior disorders. However, new clinical trials need to be performed on a larger population and for a longer period of treatment before definitive conclusions can be made. This trial is registered with NCT01890070.