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Mediators of Inflammation
Volume 2017, Article ID 9327136, 8 pages
https://doi.org/10.1155/2017/9327136
Research Article

High Neutrophil-to-Lymphocyte Ratio Predicts Cardiovascular Mortality in Chronic Hemodialysis Patients

1Department of Blood Purification, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China
2Nephrology Faculty, Capital Medical University, Beijing, China

Correspondence should be addressed to Shixiang Wang; nc.ude.umcc@gnawxs

Received 27 October 2016; Revised 12 January 2017; Accepted 29 January 2017; Published 21 February 2017

Academic Editor: Giorgio Zauli

Copyright © 2017 Han Li et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The neutrophil-to-lymphocyte ratio (NLR) is a novel simple biomarker of inflammation. It has emerged as a predictor of poor prognosis in cancer and cardiovascular disease in general population. But little was known of its prognostic value in chronic hemodialysis (HD) patients. Here we investigated the association between NLR and cardiovascular risk markers, including increased pulse pressure (PP), left ventricular mass index (LVMI) and intima-media thickness (IMT), and mortality in HD patients. Two hundred and sixty-eight HD patients were enrolled in this study and were followed for 36 months. The primary end point was all-cause mortality and cardiovascular mortality. Multivariable Cox regression was used to calculate the adjusted hazard ratios for NLR on all-cause and cardiovascular survival. We pinpointed that higher NLR in HD patients was a predictor of increased PP, LVMI, and IMT; HD patients with higher NLR had a lower survival at the end of the study; furthermore, high NLR was an independent predictor of all-cause and cardiovascular mortality when adjusted for other risk factors. In conclusion, higher NLR in HD patients was associated with cardiovascular risk factors and mortality.