Low-Copy Number Polymorphism in DEFA1/DEFA3 Is Associated with Susceptibility to Hospital-Acquired Infections in Critically Ill Patients

Table 2

Infection characteristics of the HAIs group.

Infection characteristics	HAIs (), n (%)
Identical infection with positive pathogen culture	101 (95.3%)
Source of infection
Respiratory	77 (72.6%)
Abdomen	42 (39.6%)
Bloodstream	23 (21.7%)
Urinary tract	8 (7.5%)
Invasive vessel	7 (6.6%)
Wound	5 (4.7%)
More than one locus	45 (42.5%)
Infectious organisms
Gram-positive bacteria	25 (23.6%)
Gram-negative bacteria	81 (76.4%)
Fungi	43 (40.6%)
Multiple infection^∗	71 (67.0%)
Multi-drug-resistant bacteria^#	81 (76.4%)
Specific bacterial infection
MRSA	1 (0.9%)
ESBL-producing E. coli	9 (8.5%)
MDR-AB	41 (38.7%)

HAIs: hospital-acquired infections; n: number of subjects; MRSA: methicillin-resistant Staphylococcus aureus; ESBL: extended-spectrum beta-lactamase; MDR-AB: multi-drug-resistant Acinetobacter baumannii. Multiple infection refers to infection caused by at least two pathogens. Multidrug-resistant bacteria^# are defined as isolated pathogens with resistance to at least three types of antimicrobial drugs. A patient might be infected in more than one locus or by more than one organism.