Low-Copy Number Polymorphism in DEFA1/DEFA3 Is Associated with Susceptibility to Hospital-Acquired Infections in Critically Ill Patients

Table 3

Distribution of DEFA1/DEFA3 copy number in HAIs patients and controls.

CNV	HAIs ()	Controls ()
2	6	3
3	11	9
4	10	11
5	19	7
6	10	9
7	8	12
8	14	13
9	11	18
10	3	11
11	11	8
12	3	5
13	0	2
14	0	0
15	0	0
16	0	1
Median	6	8
value	0.017
CNV < 7	56 (52.8%)	39 (35.8%)
CNV ≧ 7	50 (47.2%)	70 (64.2%)
^#OR (95% CI)	2.010 (1.164–3.473)
value	0.012

HAIs: hospital-acquired infections; n: number of subjects; CNV: copy number variation. Risk was calculated using odds ratio (OR) (confidence interval (CI)). Each value < 0.05 was considered to be significant. DEFA1/DEFA3 CNV of each group was a continuous variable, and the value was obtained by the Mann–Whitney test. CNV was categorized into two groups (CNV < 7 and CNV ≥ 7), and then value was obtained by chi-square test. The ^#OR and 95% CI show the risk effect of CNV < 7 to HAIs.