Low-Copy Number Polymorphism in DEFA1/DEFA3 Is Associated with Susceptibility to Hospital-Acquired Infections in Critically Ill Patients

Table 4

Logistic regression of DEFA1/DEFA3 copy number and occurrence of HAIs in critically ill patients.

Model	Covariants	value	OR	CI (95%)
Predictive model	CNV < 7	0.001	3.014	1.609–5.648
	APS	<0.001	1.142	1.081–1.207
	Emergency source^#	0.008	2.522	1.269–5.012

Risk was calculated by the odds ratio (OR) (confidence interval (CI)). Each value < 0.05 was considered to be significant. APS: Acute Physiology Score; CNV: copy number variation; CNV < 7: categorical variable, if DEFA1/DEFA3 CNV less than 7 copies = 1, and if CNV ≥ 7, it would be 0; Emergency source^#: categorical variable and whether the patient was from an emergency department = 1, while if the patient was not from an emergency department = 0. APS scores were continuous variables and entered the regression with the actual value. We use binary logistics regression (forward, LR) to fit the model with an entry level of 0.05 and an exclusion level of 0.10.