|
| Fatty acid | Condition | Study model | Treatment time | Dose/concentration | Molecules associated | Effect in tissue repair | Reference |
|
| LA | Wound healing | Diabetic Wistar rats | 18 days | 0.22 g/Kg bw (oral administration) | Increased VEGF and ANGPT-2 | Accelerated the inflammatory phase and angiogenesis | [38] |
| Pressure ulcers | Healthy humans | 21 days | 1.6 g EFA with LA extracted from sunflower oil (topical application) | NA | Increased hydration and elasticity. | [40] |
| Wound healing | Healthy rats | 12 days | 0.14 g solution with TGs, LA, vitamins A and E, and soy lecithin (topical application) | NA | No effects | [41] |
| Wound healing | Zebrafish | 48 hours | 10–100 μg/mL of lucuma nut oil | NA | Improved regeneration (100 μg/mL) | [42] |
| CD-1 mice | 11 days | 200, 500, or 1000 μg of lucuma nut oil (topical application) | NA | Improved wound healing and formation of new blood vessels (500 and 1000 μg) |
| Wound healing | Healthy rats | 11 days | 0.52 μL/mm2 of pumpkin oil (topical application) | Increased hydroxyproline content | Accelerated wound closure and bleeding time, improved fibrin stabilization, increased migration of fibroblasts, and reduced infiltration of macrophages | [43] |
| Wound healing | Healthy BALB/c mice | 20 days | 30 μM of pure LA (topical application) | Increased NO production | Accelerated tissue repair | [45] |
| Wound healing | Healthy Wistar rats | 24 hours | 300 μL of pure LA (topical application) | Increased total protein and DNA contents and elevated VEGF-α and IL-1 | No effect on wound area | [48] |
| Wound healing | Healthy Wistar rats | 5 days | 0.22 g/Kg bw of pure LA (oral administration) | Increased H2O2 and AP-1 and reduced NF-κB, IL-1β, and IL-6 | Accelerated the inflammatory phase | [49] |
| Neutrophil functions | Intraperitoneal neutrophils from healthy Wistar rats | 10 days | 0.11, 0.22, and 0.44 g/kg of bw (oral administration) | Increased L-selectin, IL-1β, and CINC-2αβ | Increased leukocyte-endothelium interactions | [52] |
| Neutrophil functions | Intraperitoneal neutrophils from healthy Wistar rats | 20 minutes | 0, 10, 25, 50, 100, and 200 μM (in vitro) | Increased O2− and H2O2 (50 μM) | Increased ROS | [53] |
| Macrophage functions | Macrophages from healthy Wistar rats | 10 days | 0.22 g/Kg bw (oral administration) | Reduced IL-6, VEGF, and IL-10 | Modulated cytokine production by macrophages | [59] |
|
