Review Article
Wound Healing and Omega-6 Fatty Acids: From Inflammation to Repair
Table 4
Effects of arachidonic (AA) fatty acid.
| | Fatty acid | Condition | Study model | Treatment time | Dose/concentration | Molecules associated | Effect in tissue repair | Reference |
| | AA | Wound healing | hUCB-MSC | 24 hours | 5 or 10 μM (in vitro) | Increased mTORser2481, Aktser407, PKCζ, and MMPs | Increased cell migration and angiogenesis (10 μM) | [91] | | Intestinal ischemic injury | Pigs | 10 days | 0.5 or 5% of AA (diet) | Increased PGE2 | Preservation of epithelial barrier (5%) | [95] | | IBD | Rats | 8 weeks | 0, 5, 35, or 240 mg/Kg of bw (oral administration) | Increased COX-2, LTB4, TXB2, and MPO | Increased inflammation and macrophage infiltration | [98] | | Angiogenesis | Porcine endothelial cells | 24 hours | 0, 20, 50, 60, and 80 μM (in vitro) | NA | Increased cell spreading (20 μM) and reduced cell spreading (80 μM) | [101] |
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Prostaglandin E2 (PGE2); inflammatory bowel disease (IBD); body weight (bw); cicloxigenase-2 (COX-2); leukotriene B4 (LTB4); thromboxane (TXB2); myeloperoxidase (MPO); human umbilical cord blood-derived mesenchymal stem cell (hUCB-MSC); mammalian target of rapamycin complex 1 phosphorylation (mTORser2481); protein kinase B (Aktser407); phosphorylates protein kinase Cζ (PKCζ); matrix metalloproteinases (MMPs); not analysed (NA).
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