Table 4: Effects of arachidonic (AA) fatty acid.

Fatty acidConditionStudy modelTreatment timeDose/concentrationMolecules associatedEffect in tissue repairReference

AAWound healinghUCB-MSC24 hours5 or 10 μM (in vitro)Increased mTORser2481, Aktser407, PKCζ, and MMPsIncreased cell migration and angiogenesis (10 μM)[91]
Intestinal ischemic injuryPigs10 days0.5 or 5% of AA (diet)Increased PGE2Preservation of epithelial barrier (5%)[95]
IBDRats8 weeks0, 5, 35, or 240 mg/Kg of bw (oral administration)Increased COX-2, LTB4, TXB2, and MPOIncreased inflammation and macrophage infiltration[98]
AngiogenesisPorcine endothelial cells24 hours0, 20, 50, 60, and 80 μM (in vitro)NAIncreased cell spreading (20 μM) and reduced cell spreading (80 μM)[101]

Prostaglandin E2 (PGE2); inflammatory bowel disease (IBD); body weight (bw); cicloxigenase-2 (COX-2); leukotriene B4 (LTB4); thromboxane (TXB2); myeloperoxidase (MPO); human umbilical cord blood-derived mesenchymal stem cell (hUCB-MSC); mammalian target of rapamycin complex 1 phosphorylation (mTORser2481); protein kinase B (Aktser407); phosphorylates protein kinase Cζ (PKCζ); matrix metalloproteinases (MMPs); not analysed (NA).