Bisdemethoxycurcumin and Its Cyclized Pyrazole Analogue Differentially Disrupt Lipopolysaccharide Signalling in Human Monocyte-Derived Macrophages

Figure 3

Effects of GG9, dexamethasone (dexa), and CLI-095 on the M2 macrophage phenotype as defined by CD206⁺/CD163⁺ cells. Cells were activated and treated as described in the legend to Figure 1. Fluorescence quantification dot plots (a) are from a representative experiment. (b) Bars represent the mean (±SEM) fraction of CD206⁺/CD163⁺ cells after pretreatment with test agents as indicated from 5-6 independent experiments. (c) Fraction of CD206⁺/CD163⁺ resting macrophages following treatment with test agents for 24 h as indicated. ; versus resting; and versus LPS.

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