CD28 Genetic Variants Increase Susceptibility to Diabetic Kidney Disease in Chinese Patients with Type 2 Diabetes: A Cross-Sectional Case Control Study

Table 2

Association between validated SNPs and DKD-related traits in study participants.

SNP	Chr	Gene	Position (building 37)	Minor/major allele	Traits	Stage 1 ()			Stage 2 ()			Meta-analysis
							SE	value		SE	value		SE	value
rs3116494	2	CD28	204592021	G/A	Creatinine	3.34	2.47	0.1763	5.59	3.54	0.1143	4.08	2.03	0.0442
					eGFR	-3.27	1.89	0.0836	-3.91	2.41	0.1047	-3.51	1.49	0.0181
					uAER	10.86	7.34	0.1390	2.75	2.08	0.1861	3.35	2.00	0.0939
rs3850890	3	CD80	119265619	C/T	Creatinine	2.16	1.68	0.1985	1.88	1.96	0.3375	2.04	1.28	0.1095
					eGFR	-2.37	1.57	0.1312	-2.97	1.34	0.0267	-2.72	1.02	0.0077
					uAER	19.94	11.16	0.0740	2.61	1.19	0.0283	2.80	1.18	0.0178

values were calculated by multiple linear regression under an additive genetic model adjusted for age, gender, body mass index, duration of diabetes, and HbA1c; the effect values were evaluated by minor allele. was considered statistically significant. Chr: chromosome; eGFR: estimated glomerular filtration rate; uAER: urinary albumin excretion rate.