Mediators of Inflammation

Modulation of Toll-like Receptor Signalling as a New Therapeutic Principle


Publishing date
01 Aug 2010
Status
Published
Submission deadline
02 Feb 2010

1Department of Pneumology, University Hospital of Bern, 3010 Bern, Switzerland

2Department of Dermatology and Allergy, University of Bonn, Sigmund-Freud-Strasse 25, 53105 Bonn, Germany

3Department of Biochemistry, School of Life Sciences, University of Sussex, Falmer, Brighton BN1 9QG, UK

4School of Biochemistry and Immunology, Trinity College Dublin, Ireland

5Opsona Therapeutics Ltd., The Trinity Centre for Health Sciences, Institute of Molecular Medicine, St. James's Hospital, Dublin, Ireland

6Institute for Medical Microbiology, Immunology and Hygiene, Technical University of Munich, 81675 Munich, Germany


Modulation of Toll-like Receptor Signalling as a New Therapeutic Principle

Description

The past 10 years in immunology were characterized by breakthrough progress in the field of innate immunity, especially by the definition of the interleukin-1 receptor (IL-1R)/Toll-like receptor (TLR) superfamily. Toll-like receptors are pattern recognition receptors that play a predominant role for innate immunity and inflammation. After much insights into the basic signalling events, the next step will be to unravel the therapeutic potential of the modulation of different TLR/IL1R-pathways. These pathways are involved in many different pathologies, and the therapeutic interference could have a substantial clinical benefit in a variety of diseases, ranging from allergy, over atherosclerosis, to cancer.

We invite authors to present original research articles as well as review articles that will stimulate the continuing efforts in defining the role of innate immunity signalling pathways in clinical applications. We are particularly interested in manuscripts that report the clinical applications of approved or investigational TLR-modulating therapy in various fields of medicine (cardiovascular, oncology, dermatology, pneumology, etc.) with emphasis on efficacy, toxicity, response assessment, prognostic factors, and predictive markers. Reviews that summarize the results of basic research on Toll-like receptors and innate immunity receptors, or those receptors as targets in clinical trials and their future implications on treatment practice, are particularly welcome. Potential topics include but are not limited to:

  • Clinical implications of innate immune signalling
  • Therapeutical exploitation of signalling
  • Clinical trials on innate immune signalling

Before submission authors should carefully read over the journal's Author Guidelines, which are located at http://www.hindawi.com/journals/mi/guidelines/. Prospective authors should submit an electronic copy of their complete manuscript through the journal Manuscript Tracking System at http://mts.hindawi.com/ according to the following timetable:


Articles

  • Special Issue
  • - Volume 2010
  • - Article ID 986596
  • - Review Article

Classification, Mechanisms of Action, and Therapeutic Applications of Inhibitory Oligonucleotides for Toll-Like Receptors (TLR) 7 and 9

Petar S. Lenert
  • Special Issue
  • - Volume 2010
  • - Article ID 940383
  • - Research Article

Normal Human Gingival Epithelial Cells Sense C. parapsilosis by Toll-Like Receptors and Module Its Pathogenesis through Antimicrobial Peptides and Proinflammatory Cytokines

Raouf Bahri | Sèverine Curt | ... | Mahmoud Rouabhia
  • Special Issue
  • - Volume 2010
  • - Article ID 568396
  • - Review Article

Toll-like Receptor 4 Modulation as a Strategy to Treat Sepsis

X. Wittebole | D. Castanares-Zapatero | P. F. Laterre
  • Special Issue
  • - Volume 2010
  • - Article ID 976024
  • - Review Article

Pattern Recognition via the Toll-Like Receptor System in the Human Female Genital Tract

Kaei Nasu | Hisashi Narahara
  • Special Issue
  • - Volume 2010
  • - Article ID 674363
  • - Review Article

Targeting TLR/IL-1R Signalling in Human Diseases

Maria Loiarro | Vito Ruggiero | Claudio Sette
  • Special Issue
  • - Volume 2010
  • - Article ID 423241
  • - Research Article

Inhibition of Toll-Like Receptor 2-Mediated Interleukin-8 Production in Cystic Fibrosis Airway Epithelial Cells via the 7-Nicotinic Acetylcholine Receptor

Catherine M. Greene | Hugh Ramsay | ... | Noel G. McElvaney
Mediators of Inflammation
 Journal metrics
Acceptance rate35%
Submission to final decision77 days
Acceptance to publication30 days
CiteScore3.570
Impact Factor3.545
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