Research Article

Repeated Working Memory Training Improves Task Performance and Neural Efficiency in Multiple Sclerosis Patients and Healthy Controls

Table 4

(a) 3-back correct responses. Omnibuses of the ANCOVA (covariates: sex and age) for the number of correct responses during 3-back performance. Within and between comparisons were conducted using Bonferroni post-hoc tests, and their corresponding significance levels (p) and effect sizes (Cohen’s d and its 95% confidence interval) are reported. Statistically significant effects are highlighted in bold (U: untrained; T: trained).

3-BACK CORRECT RESPONSES

MAIN EFFECTSDESCRIPTIVE STATISTICS AND MEANS COMPARISONS
Group (F1,52= 0.72, p= 0.40, η2 = 0.014)UNTRAINEDS1S2S3WITHIN GROUPS - UNTRAINED
Training (F1,52= 2.78, p= 0.10, η2= 0.51)Mean13.1412.9314.06S1-S2p=1.00d= 0.06(-0.67, 0.79)
Session (F2,51= 1.18, p= 0.31, η2 = 0.04)SD3.623.524.12S1-S3p=0.72d= -0.24(-0.97, 0.49)
INTERACTIONSS2-S3p=0.072d= -0.29(-1.03, 0.44)
Training x SessionTRAINEDS1S2S3WITHIN GROUPS - TRAINED
(F2,51 =19.81, p<0.001, =0.44)Mean11.1016.4116.47S1-S2p<0.001d= -1.71(-2.57, 0.86)
Training x GroupSD4.081.591.56S1-S3p<0.001d= -1.74(-2.59, 0.88)
(F1,52 =0.22, p=0.64, η2 =0.004)S2-S3p=1.00d= -0.04(-0.77, 0.69)
Session x GroupBETWEEN GROUPS ( U vs. T)
(F2,51 =0.20, p=0.82, η2 =0.008)S1S2S3
Training x Session x Groupp=0.035p<0.001p<0.001
(F2,51 =1.62, p=0.21, η2 =0.06)d= 0.53d= -1.27d= -0.77
(-0.21, 1.27)(-2.07, -0.48)(-1.53, -0.02)

(b) 3-back reaction times for correct responses. Omnibuses of the ANCOVA (covariates: sex and age) for the reaction times during 3-back performance. Within and between comparisons were conducted using Bonferroni post-hoc tests, and their corresponding significance levels (p) and effect sizes (Cohen’s d and its 95% confidence interval) are reported. Statistically significant effects are highlighted in bold. (U, untrained; T, trained).

3-BACK REACTION TIMES FOR CORRECT RESPONSES

MAIN EFFECTSDESCRIPTIVE STATISTICS AND MEANS COMPARISONS
Group (F1,52 = 2.16, p=0.15, η2 =0.04)UNTRAINEDS1S2S3WITHIN GROUPS - UNTRAINED
Training (F1,52 = 22.39, p<0.001, =0.30)Mean705.36664.29610.16S1-S2p=0.126d= -0.29(-0.44, 1.02)
Session (F2,51 = 2.72, p=0.075, η2 =0.096)SD144.77135.26125.64S1-S3p<0.001d= -0.70(-0.05, 1.45)
INTERACTIONSS2-S3p<0.01d= -0.41(-0.32, 1.15)
Training x SessionTRAINEDS1S2S3WITHIN GROUPS - TRAINED
(F2,51 = 12.80, p<0.001, =0.33)Mean634.93461.81479.10S1-S2p<0.001d= -1.31(0.51, 2.11)
Training x GroupSD155.24104.73107.11S1-S3p<0.001d= -5.34(3.79, 6.90)
(F1,52 =0.69, p=0.41, η2 =0.01)S2-S3p=1.00d= -1.17(0.38, 1.96)
Session x GroupBETWEEN GROUPS ( U vs. T)
(F2,51 =0.81, p=0.45, η2 =0.03)S1S2S3
Training x Session x Groupp=0.071p<0.001p<0.001
(F2,51 =0.11, p=0.89, η2 =0.005)d= 0.47d= 1.67d= 1.12
(-0.27, 1.21)(0.83, 2.52)(0.34, 1.91)