background impair balanc common peopl multipl sclerosi can present even those mild disabl level with increas disabl gait balanc impair progress lead increas risk fall some recent studi interact commerci video game were use improv balanc limit lack individu train paramet set need rehabilit purpos the aim studi evalu feasibl effect balanc exercis home set use rehabilit homebal system method singlecentr control singl blind studi alloc intervent group control group utilis particip were assess baselin after four week homebas balanc train followup after four week the primari outcom were berg balanc test bbt the secondari outcom measur includ minibestest time test part minibestest spatiotempor gait paramet evalu use gaitrite instrument the patient report outcom pro includ 12item walk scale activitiesspecif balanc confid scale fall efficaci scale result total 39 peopl multipl sclerosi 10 men were enrol studi the mean age particip 4069 102 year mean diseas durat 1476 91 year mean disabl level 38 19 edss edss rang 157 statist signific improv within home exercis group were present bbt minibestest this improv more signific subgroup moder higher disabl edss 457 all other gait paramet pro did show ani improv followup assess after four week show reach improv persist short time period after finish regular train regimen conclus comparison intervent shortterm programm homebas balanc train use homebal improv balanc gait perform group peopl seem homebas balanc train tailor accord individu need physiotherapist may futur approach consid telerehabilit peopl

Klara Novotna

Marketa Janatova

Karel Hana

Olga Svestkova

Jana Preiningerova Lizrova

Eva Kubala Havrdova

Biofeedback Based Home Balance Training can Improve Balance but Not Gait in People with Multiple Sclerosis

background objectiv multipl sclerosi epidemiolog path global main due chang environment factor the preval rise middl east persian gulf region our observ has led hypothes heavi mri lesion load onset diseas relat younger nativ popul aim estim character onset diseas mri use mcdonald criteria while appli it term dissemin space dis dissemin time dit materi method retrospect review onset mri studi 181 emirati nativ individu basic demograph were captur onli 47 patient clinic definit cdms were includ who had onset diagnost mri avail lesion load quantifi use specif zone involv design dis 1 periventricular pvz 2 juxtacort 3 infratentori iii 4 spinal cord pvz subclassifi lesion were quantifi singl enhanc lesion requir dit result averag age onset about 26 year femal domin about 2 1 about 50 had all 4 zone about 85 had least 3 zone involv onset involvement onli 1 zone rare dissemin time dit brain cord present approxim 50 each 4 zone were involv least 70 case pvz spare ani case least 3 lesion present approx 95 12 lesion approx half patient spinal cord specif cervic cord involv 80 typic patchi lesion conclus onset diseas character use mri young emirati cohort show heavi lesion load brain spinal cord onset signifi cumul diseas befor present dissemin diseas also facilit earli diagnosi the find have signific potenti ramif local environment cultur factor well diseas cours disabl progress

Manzoor Ahmed

Ruqqiya Mir

Mustafa Shakra

Safana Al Fardan

Multiple Sclerosis in the Emirati Population: Onset Disease Characterization by MR Imaging

background peopl multipl sclerosi pwms disabl general assess basi ambul abil wherea upper limb motor dysfunct less frequent consid nevertheless can sever affect qualiti life pwms date remain most unknown whether relationship exist between upper lower limb impair aim investig exist relationship between upper lower limb impair pwms base two fundament motor task name walk handtomouth htm movement method twentyeight pwms expand disabl status scale edss score rang 16 21 healthi control underw kinemat analysi gait htm movement perform motion captur system the spatiotempor paramet two task were calcul correl use spearman rank correl coeffici result the pwms perform wors than both task small larg correl were found between total htm movement durat most gait paramet rho 035068 conclus both upper lower limb motor abil pwms worsen disabl increas nevertheless relationship onli moder this find emphas need specif test quantifi disabl consid overal motor function pwms

Giancarlo Coghe

Federica Corona

Giuseppina Pilloni

Micaela Porta

Jessica Frau

Lorena Lorefice

Giuseppe Fenu

Eleonora Cocco

Massimiliano Pau

Is There Any Relationship between Upper and Lower Limb Impairments in People with Multiple Sclerosis? A Kinematic Quantitative Analysis

objectiv cognit impair common symptom multipl sclerosi yet treatment current limit the primari goal pilot studi assess feasibl accept athom fiveweek computer speed process sop train intervent patient addit examin util intervent improv speed inform process memori execut function healthrel qualiti life hrqol method fifteen subject were assign five week sop train two time per week total ten session subject were train five computer sop task requir process increas complex visual stimuli success shorter present time subject were given neuropsycholog test batteri includ measur speed inform process verbal memori visual spatial memori execut function subject were also administ patientreport outcom pro measur assess hrqol depress work product neuropsycholog pro batteri were complet baselin after five week result eighti percent subject complet fiveweek intervent 12 signific improv were observ some all measur speed inform process verbal memori execut function there were signific chang hrqol conclus this pilot studi support feasibl athom sop train intervent individu sop train associ improv sever cognit domain larger random control trial warrant

Lindsay Barker

Brian C. Healy

Emily Chan

Kaitlynne Leclaire

Bonnie I. Glanz

A Pilot Study to Assess At-Home Speed of Processing Training for Individuals with Multiple Sclerosis

background objectiv explor effect specif work memori train program patient healthi control method 29 patient 29 match were enrol studi were random split two group nontrain group 15hc 14 train group 14 15 train group underw adapt nback train 60 min day 4 day function magnet reson imag fmri use monitor brain activ dure nback perform condit 0back 2back 3back 3 time point 1 baselin 2 posttrain 7day 3 followup 35day result posttrain followup fmri session train group patient exhibit signific reaction time reduct increas correct respons crs dure 2back 3back perform this improv task perform accompani decreas brain activ frontopariet network the two effect were signific correl conclus after train both cognit preserv patient particip show task perform improv made possibl neuroplast process enhanc neural effici

Naiara Aguirre

Álvaro Javier Cruz-Gómez

Anna Miró-Padilla

Elisenda Bueichekú

Ricardo Broseta Torres

César Ávila

Carla Sanchis-Segura

Cristina Forn

Repeated Working Memory Training Improves Task Performance and Neural Efficiency in Multiple Sclerosis Patients and Healthy Controls

background fatigu one most invalid symptom multipl sclerosi negat affect occup work perform social particip occupat therapi assess treatment impair relat fatigu can have signific posit impact qualiti life method umbrella review has been carri out provid rehabilit decis maker healthcar insight role fatigu manag multipl sclerosi the question what type treatment provid occup therapist more effect reduc fatigu multipl sclerosi search literatur publish until june 2018 undertaken three independ review use pubm pedro cochran librari databas includ systemat review metaanalys last 10 year result 10 studi were select 5 systemat review 1 metaanalysi 3 review 1 guidelin conclus fatigu manag program have moder evid other strategi strategi telerehabilit show low evid

Angela Salomè

Tullia Sasso D’Elia

Giorgia Franchini

Valter Santilli

Teresa Paolucci

Occupational Therapy in Fatigue Management in Multiple Sclerosis: An Umbrella Review

background cohort studi registri provid opportun estim longterm outcom multipl sclerosi objectiv describ chang disabl edss relaps activ health care consumpt over period 20082015 combin two czech costofil studi diseas data from center pragu method the combin dataset includ 426 patient mean observ time 83 year cox proport hazard model timevari covari treatment diseas cours edss appli estim effect treatment risk progress edss 4 risk relaps the use health care resourc hospit consult test compar between two crosssect studi result total health care cost appear stabl between 2008 2015 despit more intens use diseasemodifi treatment 2015 52 patient versus 31 2008 39 patient start treatment edss 03 2008 progress edss 4 higher 2015 while 65 patient start edss 02 remain stabl the number relaps associ higher risk progress margin structur cox model relaps risk treatment natalizumab fingolimod associ lower risk relaps hazard ratio 068 001 treatment natalizumab fingolimod associ lower risk progress edss 4 conclus our result link relaps progress indic newer treatment have better effect despit difficulti caus small sampl size administr rule guid treatment absenc random compar group

Gisela Kobelt

Linus Jönsson

Miluse Pavelcova

Eva Kubala Havrdová

Real-Life Outcome in Multiple Sclerosis in the Czech Republic

multipl sclerosi chronic progress neurodegen demyelin diseas affect central nervous system glatiram acet copaxon first diseasemodifi treatment dmt success test human 1977 approv food drug administr decemb 1996 sinc have been numer develop field advanc neuroimag allow more rapid accur diagnosi avail rang dmts includ immunosuppress monoclon antibodi oral agent more holist approach treatment multidisciplinari team improv awar need consid patient prefer patientreport outcom qualiti life the use has endur throughout advanc the purpos articl provid overview import develop field dure 20 year sinc approv review clinic data aim understand continu widespread use both drugrel efficaci versus sideeffect profil monitor requir patient factor prefer regard mode administr possibl pregnanc explor

Daniel R. Wynn

Enduring Clinical Value of Copaxone&#xae; (Glatiramer Acetate) in Multiple Sclerosis after 20 Years of Use

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Multiple Sclerosis International publishes articles related to all aspects of multiple sclerosis, such as clinical neurology, neuroimaging, neuropathology, neuroimmunology, biomarkers, psychology and neurorehabilitation.

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