Changes in Amino Acid and Acylcarnitine Plasma Profiles for Distinguishing Patients with Multiple Sclerosis from Healthy Controls

Table 2

Measured concentrations of metabolites in control and multiple sclerosis groups and Mann–Whitney test comparison for median.

Metabolites	Control group			MS group			M.-W. test value
	Median conc. (μmol/ml)	Mean conc. (μmol/ml)	s.d.	Median conc. (μmol/ml)	Mean conc. (μmol/ml)	s.d.
Asp	15.0507	15.6657	5.2672	32.1554	30.6449	15.8740	0.0097
C8:1-carnitine	0.0472	0.0494	0.0121	0.0393	0.0407	0.0076	0.0530
C5OH-carnitine	0.0125	0.0125	0.0025	0.0141	0.0154	0.0066	0.0993
Glu	63.2383	62.1980	12.4526	80.8461	89.0735	41.6262	0.1457
C5-carnitine	0.0391	0.0499	0.0353	0.0337	0.0372	0.0226	0.1736
Tyr	44.6430	53.7064	25.8724	37.7501	41.5309	12.5512	0.1736
Val	78.0683	84.5595	30.3860	68.6876	74.3788	18.9949	0.2053
C3-carnitine	0.1186	0.1470	0.0707	0.1117	0.1166	0.0658	0.2226
Cit	18.9037	18.3220	4.0953	16.2658	16.6069	3.5469	0.2601
C8-carnitine	0.0251	0.0404	0.0346	0.0433	0.0416	0.0157	0.2750
Arg	45.6852	45.5796	9.9030	40.7909	41.8867	13.8405	0.3015
Pro	136.2588	160.0983	66.9696	117.1770	138.5637	66.4677	0.3470
C3DC-carnitine	0.0462	0.0449	0.0104	0.0484	0.0498	0.0102	0.3713
Met	4.2999	5.0050	1.9571	3.7745	4.7199	1.9774	0.4228
Phe	27.6062	28.6280	8.4151	22.7213	26.5824	9.0137	0.4228
Leu+Ile	75.4267	82.0059	30.8033	70.1791	75.0415	21.4271	0.5070
Orn	38.8374	39.2365	6.9759	35.1740	38.7100	14.2728	0.5369
C18:1-carnitine	0.1713	0.1752	0.0713	0.1843	0.1804	0.0523	0.5369
C10:1-carnitine	0.0498	0.0710	0.0446	0.0646	0.0610	0.0320	0.6642
Ala	122.9021	113.9486	35.2646	118.6330	124.2386	64.5191	0.8017
C2-carnitine	1.9548	2.3722	0.8908	2.2165	2.3927	0.8565	0.8017
C10-carnitine	0.0442	0.0669	0.0535	0.0543	0.0509	0.0248	0.8017
C4OH-carnitine	0.0128	0.0130	0.0057	0.0127	0.0127	0.0047	0.8344
Carnitine	15.0021	15.3318	4.0812	14.1629	15.7528	7.6604	0.8372
C4-carnitine	0.0572	0.1013	0.0848	0.0634	0.0694	0.0274	0.8731
C14:1-carnitine	0.0165	0.0183	0.0103	0.0176	0.0176	0.0058	0.9445
Gly	98.6914	103.7987	30.5344	101.8677	104.9996	30.7912	0.9454
C6-carnitine	0.0163	0.0278	0.0229	0.0208	0.0208	0.0076	0.9815

s.d.: standard deviation.