background individu multipl sclerosi experi deficit motor cognit domain result impair dualtask walk abil the goal studi compar perform forward walk backward walk singl dualtask condit person age sexmatch healthi control also examin relationship between forward backward walk cognit function balanc retrospect fall report method all measur were collect singl session mix model anova use compar differ forward backward walk singl dualtask condit between healthi control spearman correl were use examin relationship between gait cognit function fall balanc result eighteen individu relapsingremit 14 age sexmatch healthi control particip backward walk veloc reveal signific differ between group both singletask dualtask condit person demonstr signific differ between singl dualtask forward backward walk veloc wherea differ onli appar backward walk condit healthi control person were signific differ doubl support time between singl dualtask condit both backward forward direct more fall six month were signific associ shorter backward dualtask stride length slower veloc conclus differ age sexmatch healthi control more pronounc dure backward compar forward walk under singl dualtask condit futur work larger sampl size need valid clinic util backward walk dualtask assess mitig limit sensit current dualtask assess primarili reli upon forward walk

Erin M. Edwards

Deborah A. Kegelmeyer

Anne D. Kloos

Manon Nitta

Danya Raza

Deborah S. Nichols-Larsen

Nora E. Fritz

Backward Walking and Dual-Task Assessment Improve Identification of Gait Impairments and Fall Risk in Individuals with MS

the short form qualiveen sfqualiveen 8item version qualiveen questionnair use evalu impact urinari symptom qualiti life patient urolog dysfunct due neurolog disord the questionnair never avail russian languag befor the studi aim provid translat cultur adapt valid russian version sfqualiveen use patient multipl sclerosi materi method the origin english languag version sfqualiveen translat russian accord cultur linguist adapt algorithm the particip 50 patient neurogen bladder 10 relat healthi volunt fill out final russian version sfqualiveen neurogen bladder symptom score nbss twice 2 week apart the data obtain use determin intern consist cronbach alpha extern valid spearman correl testretest reliabl intraclass correl coeffici icc questionnair result the mean sfqualiveen total score patient neurogen bladder control group cronbach alpha exceed 09 indic excel intern consist questionnair the retest did reveal ani signific differ between find the testretest reliabl good all item domain icc 081089 the total score demonstr highest icc 089 the extern valid verifi strong correl demonstr between sfqualiveen nbss score conclus the russian sfqualiveen questionnair reliabl valid consist tool assess urinari disord impact qualiti life patient

Ekaterina S. Philippova

Igor V. Bazhenov

Alexander V. Ziryanov

Ekaterina Y. Moskvina

Evaluation of Lower Urinary Tract Dysfunction Impact on Quality of Life in Multiple Sclerosis Patients: Russian Translation and Validation of SF-Qualiveen

mcdonald criteria magnet reson imag mri use diagnosi multipl sclerosi nevertheless take consider amount time make clinic decis amino acid fatti acid metabol pathway disturb inform could use diagnosi the aim our studi find chang amino acid acylcarnitin plasma profil distinguish patient multipl sclerosi from healthi control have appli target metabolom approach base tandem massspectrometr analysi amino acid acylcarnitin dri plasma spot follow multivari statist analysi discoveri differ between control group found partial least squar discrimin analysi yield better group classif compar princip compon linear discrimin analysi random forest algorithm all three model detect notic chang amino acid acylcarnitin profil group relat control group our result hold promis further develop clinic decis support system

Marat F. Kasakin

Artem D. Rogachev

Elena V. Predtechenskaya

Vladimir J. Zaigraev

Vladimir V. Koval

Andrey G. Pokrovsky

Changes in Amino Acid and Acylcarnitine Plasma Profiles for Distinguishing Patients with Multiple Sclerosis from Healthy Controls

background multipl sclerosi threaten patient independ abil effect particip societi the aim studi determin correl between use social network general health multipl sclerosi patient method this studi perform 80 patient refer shiraz univers medic scienc chamran imam reza hospit 2017 whose condit had improv were treat specialist physician tool data collect were general health questionnair ghq28 social network use questionnair result amongst 80 individu 65 813 were femal 15 188 were male our result suggest patient higher level educ had higher level health telegram whatsapp respect had posit correl general health anxieti social dysfunct whatsapp 3364 most popular applic among patient the correl between general health durat use social network statist signific also signific correl found between durat use social network general health conclus our find suggest social network especi telegram whatsapp had posit correl general health anxieti social dysfunct patient therefor use social network can consid suitabl option reduc aforement concern among patient other hand general health mood status might well influenc use social network patient

Atefeh Basirat

Hadi Raeisi Shahraki

Hamid reza Farpour

Leila Habibi

The Correlation between Using Social Networks and the General Health of Multiple Sclerosis Patients

background recent ocrelizumab ocrevus approv treatment primari progress multipl sclerosi ppms base data from oratorio clinic trial realworld data about clinic effect ocrelizumab has yet gather objectiv the aim studi provid data about clinic effect ocrelizumab patient diagnos ppms realworld set method conduct retrospect cohort studi all patient ppms who start ocrelizumab treatment antonius hospit utrecht nieuwegein netherland between april 2018 decemb 31 2018 primari outcom pre versus postocrelizumab disabl worsen rate from 96 week prior first ocrelizumab administr 24 week post first ocrelizumab administr result disabl worsen rate while treatment signific differ lower from disabl worsen rate pretreat period three out 17 patient show clinic relev improv disabl status after treatment start conclus ocrelizumab can stabil disabl progress patient ppms some patient even show clinic relev improv disabl status further research should help identifi which patient benefit most from ocrelizumab

K. Daniels

P. B. van der Nat

S. T. F. M. Frequin

P. J. van der Wees

D. H. Biesma

E. L. J. Hoogervorst

E. M. W. van de Garde

Real-World Results of Ocrelizumab Treatment for Primary Progressive Multiple Sclerosis

neuromyel optica spectrum disord sever autoimmun diseas central nervous system character recurr inflammatori event primarili involv optic nerv spinal cord recent trigger role infecti event develop nmosd has been suggest varicella zoster virus most common viral infect involv though linkag antiaquaporin4 antibodi far unknown report best our knowledg first pediatr case report about nmosd relaps trigger herp zoster infect the strict tempor relationship between vzv infect nmo attack seem more than simpli due chanc howev further report need confirm

Emanuela Claudia Turco

Erica Curti

Valentina Maffini

Francesco Pisani

Franco Granella

Neuromyelitis Optica Spectrum Disorder Attack Triggered by Herpes Zoster Infection

with loss mobil multipl sclerosi come increas caregiv assist burden stress depress this 6month feasibl studi use prepost design test integr valid behavior caregiv intervent ongo clinic becaus program focus caregiv were addit servic provid person live other than usual medic care twentyf caregiv receiv reach resourc enhanc all caregiv health sixsess behaviorfocus intervent dure two three month design increas caregiv skill manag own stress burden relat issu concern focus mobil caregiv were assess baselin three six month caregiv expect program were receiv educ caregiv stress manag skill support the major benefit caregiv report were understand love one condit how better provid care six month caregiv report statist clinic signific improv depress symptom bother challeng behavior person report benefit caregiv themselv 71 report caregiv had help them mobil function studi result suggest addit brief reach caregiv intervent clinic would benefit both caregiv person although intervent six session over three month benefit persist six month suggest durabl effect this trial regist clinicaltrialsgov nct02835677

Jennifer Martindale-Adams

Jeffrey Zuber

Michael Levin

Robert Burns

Marshall Graney

Linda O. Nichols

Integrating Caregiver Support into Multiple Sclerosis Care

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Multiple Sclerosis International publishes articles related to all aspects of multiple sclerosis, such as clinical neurology, neuroimaging, neuropathology, neuroimmunology, biomarkers, psychology and neurorehabilitation.

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